The safety evaluation of ethanol extract of torbangun leaves (Coleus amboinicus Lour.) on mouse fetal development

Abstract

The purpose of this study was to evaluate the safety of ethanol extract from torbangun leaves on mouse fetal development. This research used 24 female pregnant mouse. The leaves extract was administered orally at dose level of 0; 0.56; 1.68 and 3.36 g/kg body weight. The extract was given from the first day until the eighteenth day of pregnancy period. The ethanol extract of Torbangun leaves contains flavonoids, saponins, tannins, and steroids. The result showed that consumption of 3.36 g/kg torbangun leaves extract had led to significant differences in the decrease of maternal weight change, number of live fetuses, fetal weight, and fetal length. Consumption of Torbangun leaves extract during pregnancy should be avoided due to its potency to interfere the fetal development.

Differences in the Breastfeeding Babies Anthropometic Status Based on the Practice of Mothers Consuming Torbangun (Coleus Amboinicus Lour) Leaves in Toba Regency

“…Daun torbangun merupakan bahan pangan lokal dari provinsi Sumatera Utara yang telah digunakan beberapa generasi turun-temurun bagi masyarakat suku batak terutama ibu-ibu setelah pasca melahirkan dihidangkan dalam bentuk sayur atau soup (Syarief, et al, 2014). Menurut masyarakat batak, tradisi konsumsi daun torbangun diyakini selain meningkatkan produksi ASI juga dapat pencegahan perdarahan pasca melahirkan (Alfi ah, et al, 2018). Daun torbangun memiliki kandungan yaitu carvakrol, salinene, cymene, caryophyllene oxide, thymol, humulene, undecanal, terpinene dan terpineol yang membantu merangsang produksi ASI meningkat (Hutajulu dan Junaidi, 2013).…”