The safety of New Zealand bovine colostrum: Nutritional and physiological evaluation in rats

Davis, Paul F.; Greenhill, Nicholas S.; Rowan, Angela; Schollum, Linda M.

doi:10.1016/j.fct.2006.07.034

Cited by 31 publications

(29 citation statements)

References 21 publications

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“…immediately after parturition (Levieux and Ollier 1999;Nakamura et al 2003;Godhia and Patel 2013), 2 days (Playford et al 2000;Playford 2001), 3 to 4 days (Foley and Otterby 1978;Gopal and Gill 2000;Davis et al 2007;Zhang et al 2011) or 5 to 7 days post-partum (Marnila and Korohnen 2002;Georgiev 2008;Zarcula et al 2010;Abd ElFattah et al 2012). For the purposes of this review, colostrum, unless otherwise defined, will refer to the early milkings from dairy cows, taken up to 3 days post-partum.…”

Section: Introductionmentioning

confidence: 99%

Composition and properties of bovine colostrum: a review

McGrath

Fox

McSweeney

et al. 2015

Dairy Sci. & Technol.

314

263

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Colostrum is the initial milk secreted by mammals following parturition, the composition and physicochemical properties of which are highly dynamic and variable. The composition and physicochemical properties of colostrum during the initial postpartum period has not been systematically reviewed for many years, although the topic remains of interest both to milk producers and processors. In this article, the current understanding of the composition of colostrum, i.e. carbohydrates, proteins, growth factors, enzymes, enzyme inhibitors, nucleotides and nucleosides, cytokines, fats, vitamins and minerals, is reviewed. In addition, the physicochemical properties, i.e. pH and buffering capacity, colour, density and specific gravity, osmotic pressure, somatic cell count, properties of casein micelles, ethanol stability and rennet coagulation properties are discussed, as well as the effects of heat-treating colostrum.

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Section: Introductionmentioning

confidence: 99%

Composition and properties of bovine colostrum: a review

McGrath

Fox

McSweeney

et al. 2015

Dairy Sci. & Technol.

314

263

View full text Add to dashboard Cite

show abstract

“…Some authors have reported lactose intolerance, nausea, flatulence, transient diarrhoea and unspecified abdominal discomfort as possible side effects while other studies specifically reported the absence of side effects (83,128,129,165,137,143,189,190). However, further research is required in order to confirm these data, and, more importantly, to evaluate the effects of colostrum when used for a prolonged periods of time and during pregnancy.…”

Section: Side Effects and Contraindicationsmentioning

confidence: 77%

“…According to the current state of knowledge, colostrum appears to be safe and no contraindications are observed even when administered at high concentrations both in humans and animals (189,190). Some authors have reported lactose intolerance, nausea, flatulence, transient diarrhoea and unspecified abdominal discomfort as possible side effects while other studies specifically reported the absence of side effects (83,128,129,165,137,143,189,190).…”

Section: Side Effects and Contraindicationsmentioning

confidence: 99%

Potential benefits of colostrum in gastrointestinal diseases

et al. 2016

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“…The nutritional and physiological safety of BC was evaluated by Davis et al [7]. Results showed that rats exhibited no biochemical, physical, or histopathological abnormalities after being fed for 90 days with a chow supplemented with up to 10% colostrums.…”

Section: Discussionmentioning

confidence: 99%

“…Their results showed that the promotion activity of BCE on bone development was more remarkable than that of calcium. Compared with regular bovine milk, BC not only contain abundant protein but also enrich bioactive components that can produce many physiological functions, such as immune regulation activity, antimicrobial activity, muscular/skeletal repair, and bone growth and development enhancement [7,17,19,23]. Studies have shown that colostrums are the only natural source of two major growth factors, namely (1) transforming growth factors alpha and beta and (2) insulin-like growth factors 1 and 2 (IGF-1 and IGF-2).…”

Section: Introductionmentioning

confidence: 99%

Effects of bovine colostrum acid protein on bone loss and hemobiochemistry indexes in rats

Wang

et al. 2009

Dairy Sci. Technol.

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-At present, researchers all over the world focus on the methods to prevent and cure osteoporosis. Many reports have shown that bovine milk and its basic proteins, and bovine colostrums (BC) and their extracts have positive effects on bone growth of human beings or experimental rats, such as increasing bone mineral density (BMD) and promoting calcium absorption. However, to our best knowledge, the effects of acid proteins from BC (BCAP) on bone properties have not been reported, and the effect on the potential hazard on blood lipids of rats has not been reported. This study investigated the effect of BCAP on bone loss in aged ovariectomized (OVX) rats and the hemobiochemistry parameters (HP) in serum. Forty-eight female SpragueDawley rats of clean grade were ovariectomized and another 12 rats received a sham operation. The OVX rats were randomly separated into four groups, i.e. OVX control, OVX low dose (0.04 g·d ). BCAP were applied in rat diet for 12 weeks and the rats were gavaged once a day. The effects of BCAP on HP, calcium content (CC), and BMD of femur were determined using biochemical analysis, atomic absorption spectrophotometry, and dual-energy X-ray absorptiometry. Results showed that BCAP could increase the femur weight/length. CC of femurs in rats with BCAP were significantly higher than those of shamoperated group and model control group. BCAP increased the BMD of femur. However, BCAP at a low dosage exhibited higher activity than that at a medium or high dosage. BCAP had no particular effects on the HP of rats. It is concluded that BCAP at dose < 0.04 g·d −1 can prevent osteoporosis caused by bone loss due to estrogen reduction in OVX rats, and BCAP (0.04-0.40 g·d −1 ) has no potential hazard on blood lipids of rats under present experimental condition.bovine colostrum / acid protein / bone property / hemobiochemistry / ovariectomized rat ) et OVX dose élevée (0,40 g·j −1 ). Les PACB ont été introduites dans leur régime alimentaire pendant 12 semaines sous forme de gavage une fois par jour. Les effets des PACB sur les paramètres hémobiochimiques, teneur en calcium et densité minérale osseuse du fémur ont été déterminés par analyse biochimique, spectrophotométrie d'absorption atomique et absorptiométrie biénergique à rayons X. Les résultats ont montré que les PACB pouvaient augmenter le rapport poids/longueur du fémur. Les teneurs en calcium des fémurs de rattes avec PACB étaient significativement plus élevées que celles du groupe opéré fictivement et du groupe de contrôle. Les PACB augmentaient la densité minérale osseuse du fémur. Cependant, les PACB à faible dose avaient une activité supé-rieure à celle des doses moyennes et élevées. Les PACB n'avaient pas d'effet particulier sur les paramètres hémobiochimiques des rattes. On en conclut que les PACB à doses inférieures à 0,04 g·j −1 peuvent prévenir l'ostéoporose provoquée par la perte osseuse due à la réduction des oestrogènes chez les rattes ovariectomisées, et que des doses de PACB de 0,04 à 0,40 g·j −1 ne présentent pas de risque p...

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The safety of New Zealand bovine colostrum: Nutritional and physiological evaluation in rats

Cited by 31 publications

References 21 publications

Composition and properties of bovine colostrum: a review

Composition and properties of bovine colostrum: a review

Potential benefits of colostrum in gastrointestinal diseases

Effects of bovine colostrum acid protein on bone loss and hemobiochemistry indexes in rats

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