The safety of PolyGlycopleX® (PGX®) as shown in a 90-day rodent feeding study

Matulka, Ray A.; Lyon, Michael R.; Wood, Simon; Marone, Palma Ann; Merkel, Daniel; Burdock, George A.

doi:10.1186/1475-2891-8-1

Cited by 56 publications

(55 citation statements)

References 28 publications

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“…Physical activity and basal metabolic rate changes do not necessarily correlate. A previous study using PGX® showed no change in activity patterns (functional observation battery) and no food aversion in Sprague Dawley rats (Matulka et al, 2009). A similar study published by Reimer and Russell (2008) showed a comparable effect with a prebiotic fiber in JCR:LA-cp (leptin receptor deficient) rats showing reduced caloric intake independent of any weight loss.…”

Section: Discussionmentioning

confidence: 60%

“…Most studies showing beneficial effects of inulin or related fiber in metabolic syndrome use at least 10% wgt/wgt in the diet (Daubioul et al, 2002;Weikert et al, 2008). Because of the high viscosity of PGX®, 5% wgt/wgt was used and this was also the highest dose tested for safety (Matulka et al, 2009). Preliminary studies in man had also suggested a dose comparable to this dose to be efficacious.…”

Section: Discussionmentioning

confidence: 99%

“…The resulting polysaccharide exceeds the viscosity of the constituent ingredients as well as other currently known viscous dietary fibers. This fiber is well tolerated in rodents with a maximal tested dose being 5% wgt/wgt in diet (Matulka et al, 2009) and man (Carabin et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Effects of the soluble fiber complex PolyGlycopleX® (PGX®) on glycemic control, insulin secretion, and GLP-1 levels in Zucker diabetic rats

Grover

Koetzner

Wicks³

et al. 2011

Life Sciences

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 99%

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Effects of the soluble fiber complex PolyGlycopleX® (PGX®) on glycemic control, insulin secretion, and GLP-1 levels in Zucker diabetic rats

Grover

Koetzner

Wicks³

et al. 2011

Life Sciences

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“…A proprietary process causes strong interactions to form between konjac (glucomannan), sodium alginate and xanthan gum to produce a resultant polysaccharide complex with a level of viscosity that is higher than any currently known individual polysaccharide. The final product is a novel, soluble, highly viscous polysaccharide (functional fiber) that has been shown to be well tolerated by rodents (Matulka et al, 2009) and man (Carabin et al, 2009). Genotoxicity studies of PGX have shown no mutagenic effects using bacterial reverse mutation and mouse micronucleus assays .…”

Section: Introductionmentioning

confidence: 99%

Increased plasma PYY levels following supplementation with the functional fiber PolyGlycopleX in healthy adults

Reimer

Pelletier²,

Carabin³

et al. 2010

Eur J Clin Nutr

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Background/Objectives: A variety of dietary fibers have been shown to alter satiety hormone gene expression and secretion. The objective of this study was to examine plasma satiety hormone concentrations in healthy subjects consuming either PolyGlycopleX (PGX) or control (skim milk powder) for 21 days. Subjects/Methods: A randomized, double-blind, placebo-controlled clinical study was conducted in 54 healthy male and female adults. Participants consumed 5 g per day of PGX or control for 1 week followed by 2 additional weeks of 10 g per day of assigned product (n ¼ 27 per group). Primary outcomes measured at three visits (V1, V2 and V3) were plasma active glucagon-like peptide-1 (GLP-1) total ghrelin, peptide YY (PYY) and insulin.Results: There was a significant effect of visit for fasting PYY with control participants experiencing decreased PYY levels over time while PGX prevented this decline. When stratified by body mass index (BMI), PGX increased fasting PYY levels from week 1 to week 3 compared with control in participants with BMI o23 kg/m 2 . There was a significant effect of visit for fasting ghrelin with levels decreasing in both PGX and control groups over time. No differences were detected in fasting GLP-1 levels. Although there was a 14% reduction in fasting insulin between V1 and V3 with PGX this was not significantly different from control. Conclusions: PGX is a highly viscous, functional fiber that modifies satiety hormone secretion in healthy adults. Its' potential to act similarly in overweight adults warrants investigation.

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“…36,43 But with the levels of PCV and Hb unaffected, the reduction in RBC may also arise from other sources including increased water intake, hemolysis or suppression of erythropoietin production. 44,45 The reduction of WBC by extract is suggestive of the effect of some of the constituents on WBC circulation or formation. …”

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confidence: 99%

Determination of the inorganic composition and short term effect of aqueous extracts of root, pod, and stem of Telfairia occidentalis on some hematological parameters in rats

Ogbonnaya

Uadia

2016

Asian J Med Sci

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Aims and Objectives:This study is to investigate the inorganic composition and the effect of fourteen (14) -day oral administration of aqueous extracts of root, pod and stem of Telfairia occidentalis in rats.Materials and Methods: Plant samples were analyzed for K, P, Mg, Ca, S, Mn, Fe, Cu, Zn, Pb, and Crusing atomic absorption spectrophotometry (AAS). Wister rats of both sexes were assigned to sixteen (16) groups of 4 animals per group. Different animal groups received distilled water and root, stem, and pod extracts at the doses of 250, 750, 1500, 2250, and 3000mg/kg of body weight. All animals were treated for 14 days and sacrificed on the 15 th day. Results: The inorganic composition result showed that potassium (K) was the highest in abundance in all the samples (root, pod, and stem), compared to the other mineral elements. The root contained high levels of potassium and manganese; the stem had magnesium, manganese and iron while the pod contained high amount of potassium, manganese and iron. Hematological assay results showed reduction in the values of white blood cell (WBC) count for higher doses of root extract and all doses (except for 1500 mg/kg bw) of pod extract. Platelet count (PLT) was significantly high for root extract at 750 mg/kg bw. The stem extract showed a consistent decrease in the red blood cell (RBC) count for all dose administered. Conclusion: Telfairia occidentalis root, pod, and stem may be good sources of inorganic elements. The extracts have varying effects on hematological parameters which may be dosage-and duration-dependent.

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The safety of PolyGlycopleX® (PGX®) as shown in a 90-day rodent feeding study

Abstract: Background: This study was designed to evaluate the safety of PolyGlycopleX ® (PGX ® ), a novel viscous dietary polysaccharide (fiber), when administered to Sprague Dawley ® rats in the diet for 90 days.

Cited by 56 publications

References 28 publications

Effects of the soluble fiber complex PolyGlycopleX® (PGX®) on glycemic control, insulin secretion, and GLP-1 levels in Zucker diabetic rats

Effects of the soluble fiber complex PolyGlycopleX® (PGX®) on glycemic control, insulin secretion, and GLP-1 levels in Zucker diabetic rats

Increased plasma PYY levels following supplementation with the functional fiber PolyGlycopleX in healthy adults

Determination of the inorganic composition and short term effect of aqueous extracts of root, pod, and stem of Telfairia occidentalis on some hematological parameters in rats

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