The Science and Pervasiveness of Laboratory Animal Allergy

Wolfle, Thomas L.; Bush, Robert K.

doi:10.1093/ilar.42.1.1

Cited by 13 publications

(8 citation statements)

References 6 publications

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“…As many imaging facilities are utilized both for human and animal scanning, the potential for cross-contamination exists. Human B virus exposure is always a concern when macaques are involved (Cohen et al, 2002) and human allergies to rodents, dogs, and cats are common (Wolfle and Bush, 2001). In addition, some animals may be susceptible to zoonotic diseases from humans; for example Old World nonhuman primates, such as rhesus macaques, are particularly susceptible to tuberculosis (Aiello, 1998b).…”

Section: Special Considerations Of Animal Maintenance In the Imaging mentioning

confidence: 99%

Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research

Earth¹

2003

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Section: Special Considerations Of Animal Maintenance In the Imaging mentioning

confidence: 99%

Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research

Earth¹

2003

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“…Allergic reactions to animals are among the most common conditions that adversely affect the health of workers involved in the care and use of animals (NRC 1997). It has been estimated that up to 46% of laboratory animal workers develop allergies to laboratory animals (Wolfle and Bush 2001). Respiratory protection can help reduce personal exposure to animal allergens (Harrison 2001).…”

Section: Voluntary Use Of Respiratorsmentioning

confidence: 99%

Chemical Safety in Animal Care, Use, and Research

Thomann¹

2003

ILAR Journal

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Chemical safety is an essential element of an effective occupational health and safety program. Controlling exposures to chemical agents requires a careful process of hazard recognition, risk assessment, development of control measures, communication of the risks and control measures, and training to ensure that the indicated controls will be utilized. Managing chemical safety in animal care and use presents a unique challenge, in part because research is frequently conducted in two very different environments--the research laboratory and the animal care facility. The chemical agents specific to each of these environments are typically well understood by the employees working there; however, the extent of understanding may not be adequate when these individuals, or chemicals, cross over into the other environment. In addition, many chemicals utilized in animal research are not typically used in the research laboratory, and therefore the level of employee knowledge and proficiency may be less compared with more routinely used materials. Finally, the research protocol may involve the exposure of laboratory animals to either toxic chemicals or chemicals with unknown hazards. Such animal protocols require careful review to minimize the potential for unanticipated exposures of the research staff or animal care personnel. Numerous guidelines and regulations are cited, which define the standard of practice for the safe use of chemicals. Key chemical safety issues relevant to personnel involved in the care and use of research animals are discussed.

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“…Workers exposed to laboratory animals frequently develop allergic symptoms, a condition known as laboratory animal allergy (LAA) 1 , characterized by urticaria, conjunctivitis, rhinitis and asthma 2 . Prevalence of LAA may range from 11 to 44%, wherein this large variation in prevalence is due to the different criteria for defining LAA, with definitions based on reports of symptoms or laboratory tests 3,4 .…”

Section: Introductionmentioning

confidence: 99%

Exposição prolongada a animais de laboratório está associada ao aumento de casos de asma

Simoneti

Nocera

Vianna

2020

Rev. bras. saúde ocup.

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Resumo Objetivo: descrever o resultado do acompanhamento de trabalhadores sensibilizados a animais de laboratório que prolongaram sua exposição. Métodos: após um período de aproximadamente 7 anos, entramos em contato com todos os indivíduos com sensibilização alérgica ocupacional detectada em estudo anterior. Um questionário foi aplicado para situação ocupacional atual, relação entre alergia e a decisão de deixar o trabalho ou exposição e para asma, sibilância, rinite, sintomas cutâneos e dispneia noturna. Resultados: dos 74 indivíduos com sensibilização ocupacional, 45 responderam ao questionário na segunda avaliação e 37 ainda estavam expostos. Ao comparar os dados da primeira avaliação com os da avaliação atual, observou-se um aumento na frequência de asma. Na primeira avaliação, entre todos os sensibilizados (n = 74), 27,0% responderam sim a ambas as questões “Você tem ou já teve asma?” e “A asma foi diagnosticada por um médico?”. Na segunda avaliação, 7 anos depois, dos 37 sujeitos que ainda estavam expostos, 51,3% responderam sim a essas questões (OR: 2,80; IC95%: 1,23-6,38; p = 0,013). Não houve mudança na frequência de respostas positivas às outras perguntas. Conclusão: os dados demonstram aumento da frequência de asma entre trabalhadores com sensibilização ocupacional que prolongam a exposição a animais de laboratório.

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The Science and Pervasiveness of Laboratory Animal Allergy

Cited by 13 publications

References 6 publications

Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research

Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research

Chemical Safety in Animal Care, Use, and Research

Exposição prolongada a animais de laboratório está associada ao aumento de casos de asma

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