The scientific foundations of clinical enzymology

Dw, Moss

doi:10.1007/bf00438297

Cited by 7 publications

(2 citation statements)

References 16 publications

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“…A marked decrease was encountered in total urinary ALP activity obtained for normal controls (0.34 ± 0.2 U/mmol creatinine) compared with the results obtained by [2] who showed that ALP for adults was 1.6 U/mmol creatinine [23] .…”

Section: Kidney Patientsmentioning

confidence: 39%

Urinary Enzymes and Microalbuminuria as Indicators of Renal Nephropathy in Saudi Patients

Lary¹

2008

sci

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Abstract. In the current work we tried to investigate some new biochemical markers in the urine of kidney patients, kidney transplant recipients and control subjects of the Saudi population, such markers are N-acetyl-β-D-glucosaminidase (NAG), Alkaline Phosphatase (ALP), Alanine Aminopeptidase (AAP) as well as microalbuminuria. Kidney patients, males and females, age ranged from 16-85 years, and kidney transplant recipients, male and female, age ranged from 18-75 years.Results from control subjects showed a slight elevation of total urinary protein and NAG in females. This may be due to the higher level of creatinine concentration in male subjects, that would result in lower protein concentration and NAG activity when expressed in terms of creatinine. Microalbuminuria, glucose and pH results were in close agreement with the published data and no sex differences were recorded when compared with the males. There were statistically significant differences in most of parameters investigated between kidney patients and the normal population except for glucose level and pH value. The reduction in creatinine concentration may reflect changes in the glomerular filtration rate (GRF). Higher levels of urinary NAG activity were associated with high microalbuminuria and raised AAP levels.Increase urinary NAG predominantly reflects decreased renal function and tubular damage. ALP increased levels reflect a lesion of the proximal convoluted tubules and/or intensive degeneration of the tubular epithelial cells. The increase in NAG activity correlates well with urinary protein and may indicate an increase in activity of renal tubular cells. Kidney transplant recipients showed a significant increase in NAG, ALP and AAP enzymes compared to control subjects. The marked increase in most parameters may indicate that patients are in an immediate functioning graft.

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Section: Kidney Patientsmentioning

confidence: 39%

Urinary Enzymes and Microalbuminuria as Indicators of Renal Nephropathy in Saudi Patients

Lary¹

2008

sci

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“…Lipid profile, CK-MB, CBC, LFT are pathologically diagnosed by the therapeutic process [41][42][43][44][45][46][47][48][49]. 1)…”

Section: Biochemical Parameters Evaluationmentioning

confidence: 99%

Effect of Colesevelam Hydrochloride Alone and Its Combination With Atorvastatin on Experimentally Induced Hyperlipidemia in Wistar Rats

2023

IJBPAS

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Atherosclerosis is a major cardio effective disorder that affects heart causing hyperlipidemia which blocks the artery, aorta and obstruct the pathway of blood flow which puts life at risk.The modern medication needs to be administered continuously and in higher doses which leads to negative drawbacks. The study aim is to give the Combination therapy treatment as per the drug mechanism of action is known and how bioavailability is also known. Five group of albino wistar rats were being experimented in this case, group I to V i.e. NC, DC, COL, ATS (40mg/kg) and ATS (10mg/kg) + COL is to give the treatment as chrono pharmacology method in combination and in low dose range of atorvastatin 10-20 mg/kg less side effect is observed. Conducting the study is seen that lower dose in combination (bile acid sequestrants and HMG-CO-A inhibitor) was proven that CK-MB levels are decreased in comparison of high dose of Atrorvastatin by Detection of Biochemical Evaluation Parameters like CK-MB, Lipid profile, CBC etc. also Detect the Histopathological parameters by differentiate the slide review of Heart and Aorta of every group according to plan of work and protocol for evaluation of formulation. As further it will come in future work can be done into cell line on molecular base to determine clinical significance.

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Studies on alkaline phosphatase isoenzymes in hepatic diseases. Relation to γ-glutamyltransferase

Burlina

Bugiardini

1978

Clinica Chimica Acta

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The scientific foundations of clinical enzymology

Cited by 7 publications

References 16 publications

Urinary Enzymes and Microalbuminuria as Indicators of Renal Nephropathy in Saudi Patients

Urinary Enzymes and Microalbuminuria as Indicators of Renal Nephropathy in Saudi Patients

Effect of Colesevelam Hydrochloride Alone and Its Combination With Atorvastatin on Experimentally Induced Hyperlipidemia in Wistar Rats

Studies on alkaline phosphatase isoenzymes in hepatic diseases. Relation to γ-glutamyltransferase

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