The <scp>TLR</scp>4‐associated phospholipase D1 activation is crucial for Der f 2‐induced <scp>IL</scp>‐13 production

Choi, Hye‐Jin; Park, S.-Y.; Cho, J. H.; Park, J.-W.; Sohn, Jungsan; Kim, Y.-J.; Oh, Jae Won; Han, Joong‐Soo

doi:10.1111/all.12764

Cited by 18 publications

(16 citation statements)

References 42 publications

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“…showed some years ago that TLR4 signaling could be initiated by the major HDM allergen Der p 2, which mimics the lipopolysaccharide (LPS)‐binding subunit MD‐2, leading to the facilitation of TLR4 signaling. Similarly, HDM allergen Der f 2 can bind directly to TLR4 and elicit pro‐inflammatory cytokine production in human bronchial ECs …”

Section: Barrier Epithelial Cells In the Lung Play An Important Role mentioning

confidence: 99%

“…Similarly, HDM allergen Der f 2 can bind directly to TLR4 and elicit pro-inflammatory cytokine production in human bronchial ECs. 67 Since a substantial proportion of HDM allergens are proteases, attention has also been given to the involvement of protease-activated receptors (PARs) on ECs. Among the four PAR family members, only PAR-2 can be activated by serine proteases that are present in HDM.…”

Section: Radiation-induced Bone Marrow Chimeras Lacking the Expressimentioning

confidence: 99%

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Interplay between barrier epithelial cells and dendritic cells in allergic sensitization through the lung and the skin

Deckers

Bosscher

Lambrecht

et al. 2017

Immunological Reviews

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The prevalence of asthma is increasing over the years and it has become obvious that a thorough understanding of mechanisms leading to Th2 sensitization and to asthma is urgently needed to provide better ways to treat the disease. This articles reviews the different players involved in the initiation of allergic reactions in the lung and in the skin, and highlights the importance of a crosstalk between antigen-presenting dendritic cells and structural cell-derived signals in this process. Our increasing understanding of these mechanisms indicates that structural cells, such as airway epithelial cells and skin keratinocytes, need to be considered as more than a simple physical barrier since they are very upstream of the entire Th2 cascade and therefore might represent crucial targets for new therapies.

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Section: Barrier Epithelial Cells In the Lung Play An Important Role mentioning

confidence: 99%

Section: Radiation-induced Bone Marrow Chimeras Lacking the Expressimentioning

confidence: 99%

Interplay between barrier epithelial cells and dendritic cells in allergic sensitization through the lung and the skin

Deckers

Bosscher

Lambrecht

et al. 2017

Immunological Reviews

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“…Der p 2 activates the innate immune system through Toll-like receptors (TLR-4) by mimicking the action of human MD-2 (myeloid differentiation antigen-like lipid-binding protein), a structural homologue that loads lipopolysaccharide (LPS) onto these receptors [12]. A TLR4-associated phospholipase D1 activation has recently been reported to be crucial for Der f 2-induced IL-13 production [13]. …”

Section: Introductionmentioning

confidence: 99%

Indoor Allergens and Allergic Respiratory Disease

Pomés

Chapman

Wünschmann

2016

Curr Allergy Asthma Rep

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Purpose of review The purpose of this review is to evaluate the most recent findings on indoor allergens and their impact on allergic diseases. Recent findings Indoor allergens are present inside buildings (home, work environment, school), and given the chronic nature of the exposures, indoor allergies tend to be associated with the development of asthma. The most common indoor allergens are derived from dust mites, cockroaches, mammals (including wild rodents and pets), and fungi. The advent of molecular biology and proteomics has led to the identification, cloning, and expression of new indoor allergens, which have facilitated research to elucidate their role in allergic diseases. This review is an update on new allergens and their molecular features, together with the most recent reports on their avoidance for allergy prevention and their use for diagnosis and treatment. Summary Research progress on indoor allergens will result in the development of new diagnostic tools and design of coherent strategies for immunotherapy.

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“…However, little is known about the signals released by allergens that result in the activation of these receptors. Recent report from Choi et al [8 ▪ ] identified a Toll-like receptor 4 (TLR4)-associated phospholipase D1 (PLD1) signaling cascade that was crucial for house dust mites (HDM)-induced production of IL-13. The finding not only sheds light on the mechanism of HDM-mediated allergic inflammation but also suggests PLD1 as a novel therapeutic target.…”

Section: Innate Allergic Effector Cellsmentioning

confidence: 99%

Allergen-encoded signals that control allergic responses

Tung¹,

Landers

et al. 2016

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of review The purpose is to review the important recent advances made in how innate immune cells, microbes, and the environment contribute to the expression of allergic disease, emphasizing the allergen-related signals that drive allergic responses. Recent findings The last few years have seen crucial advances in how innate immune cells such as innate lymphoid cells group 2 and airway epithelial cells and related molecular pathways through organismal proteinases and innate immune cytokines, such as thymic stromal lymphopoietin, IL-25, and IL-33 contribute to allergy and asthma. Simultaneously with these advances, important progress has been made in our understanding of how the environment, and especially pathogenic organisms, such as bacteria, viruses, helminths, and especially fungi derived from the natural and built environments, either promote or inhibit allergic inflammation and disease. Of specific interest are how lipopolysaccharide mediates its antiallergic effect through the ubiquitin modifying factor A20 and the antiallergic activity of both helminths and protozoa. Summary Innate immune cells and molecular pathways, often activated by allergen-derived proteinases acting on airway epithelium and macrophages as well as additional unknown factors, are essential to the expression of allergic inflammation and disease. These findings suggest numerous future research opportunities and new opportunities for therapeutic intervention in allergic disease.

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The TLR4‐associated phospholipase D1 activation is crucial for Der f 2‐induced IL‐13 production

Abstract: Our data extend the knowledge for a variety of possible roles of PLD1 in allergic disorders including asthma pathogenesis and suggest possible candidacy of PLD1 as a molecular target for novel therapeutic approaches.

Cited by 18 publications

References 42 publications

Interplay between barrier epithelial cells and dendritic cells in allergic sensitization through the lung and the skin

Interplay between barrier epithelial cells and dendritic cells in allergic sensitization through the lung and the skin

Indoor Allergens and Allergic Respiratory Disease

Allergen-encoded signals that control allergic responses

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