The search for causes of the leukaemias

Alexander, Freda E.

doi:10.1016/0959-8049(95)00023-2

Cited by 9 publications

(5 citation statements)

References 53 publications

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“…Probably, female cases were underreported considering the socioeconomic status of the families and in low-resource settings usually men often get priority while seeking medical attention. The higher prevalence of HM in males might be the result of increased exposure to environmental and occupational risk factors, smoking, alcohol consumption as well as different hormonal and genetic background of males and females [10,21-23]. …”

Section: Discussionmentioning

confidence: 99%

Diagnosed hematological malignancies in Bangladesh - a retrospective analysis of over 5000 cases from 10 specialized hospitals

et al. 2014

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BackgroundThe global burden from cancer is rising, especially as low-income countries like Bangladesh observe rapid aging. So far, there are no comprehensive descriptions reporting diagnosed cancer group that include hematological malignancies in Bangladesh.MethodsThis was a multi-center hospital-based retrospective descriptive study of over 5000 confirmed hematological cancer cases in between January 2008 to December 2012. Morphological typing was carried out using the “French American British” classification system.ResultsA total of 5013 patients aged between 2 to 90 years had been diagnosed with malignant hematological disorders. A 69.2% were males (n = 3468) and 30.8% females (n = 1545), with a male to female ratio of 2.2:1. The overall median age at diagnosis was 42 years. Acute myeloid leukemia was most frequent (28.3%) with a median age of 35 years, followed by chronic myeloid leukemia with 18.2% (median age 40 years), non-Hodgkin lymphoma (16.9%; median age 48 years), acute lymphoblastic leukemia (14.1%; median age 27 years), multiple myeloma (10.5%; median age 55 years), myelodysplastic syndromes (4.5%; median age 57 years) and Hodgkin’s lymphoma (3.9%; median age 36 years). The least common was chronic lymphocytic leukemia (3.7%; median age 60 years). Below the age of 20 years, acute lymphoblastic leukemia was predominant (37.3%), followed by acute myeloid leukemia (34%). Chronic lymphocytic leukemia and multiple myeloma had mostly occurred among older patients, aged 50-over.ConclusionsFor the first time, our study presents the pattern and distribution of diagnosed hematological cancers in Bangladesh. It shows differences in population distributions as compared to other settings with possibly a lower presence of non-Hodgkin lymphoma. There might be under-reporting of affected women. Further studies are necessary on the epidemiology, genetics and potential environmental risk factors within this rapidly aging country.

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Section: Discussionmentioning

confidence: 99%

Diagnosed hematological malignancies in Bangladesh - a retrospective analysis of over 5000 cases from 10 specialized hospitals

et al. 2014

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“…Furthermore, increasing incidences in MDS, MPN, MDS/MPN were also detected, which could not be calculated in the previous report. Age and environmental factors [ 15 16 17 ] can be considered a potential cause of inflated incidence. A similar change was observed in the European HAEMACARE project [ 18 ], but Korean ASRs of MDS and MPN are much lower than that of European, probably because of ethnic or regional differences.…”

Section: Discussionmentioning

confidence: 99%

Nationwide statistical analysis of myeloid malignancies in Korea: incidence and survival rate from 1999 to 2012

et al. 2015

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BackgroundLarge-scale epidemiologic analysis for hematologic malignancies will be helpful to understand the trends in incidence and survival.MethodsThe Korea Central Cancer Registry (KCCR) updated the nationwide analysis on the incidence and survival of myeloid malignancies, from the Korean National Cancer Incidence Database between 1999 and 2012. Myeloid malignancies were classified based on the International Classification of Diseases for Oncology 3rd edition (ICD-O-3).ResultsOverall 3,771 cases of myeloid diseases, which was 1.7% of all cancers, were identified in 2012. The highest incidence of myeloid malignancies was observed in age 70s and male predominance was noted (1.3:1). Acute myeloid leukemia (AML) was the most frequent subtype, followed by myeloproliferative neoplasms (MPN), myelodysplastic syndrome (MDS) and MDS/MPN: age-standardized incidence rates (ASR) in 2012 for each disease were 2.02, 1.95, 1.13, and 0.12 per 100,000 persons, respectively. The ASR for all myeloid malignancies was increased from 3.31 in 1999 to 5.70 in 2012 with the annual percentage change (APC) of 5.4 %. Five-year relative survival rate (RS) for myeloid malignancies has gradually improved for decades. RS changed from 26.3% to 34.8% in AML, specifically from 51.6% to 69.6% in acute promyelocytic leukemia (APL) and from 23.8% to 29.9% in non-APL AML, between 1996-2000 and 2008-2012. RS also increased from 81.8% to 87.1% in MPN, with a significant improvement in CML (from 74.5% to 85.5%), and from 27.3% to 31.7% in MDS/MPN between 2001-2005 and 2008-2012. However, there was no survival improvement in MDS during the study period (45.6% in 2001-2005 to 44.4% in 2008-2012).ConclusionThis report updated the nationwide statistical analysis on myeloid malignancies since 2008, showing increasing incidence and improving trends in survival.

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“…Undoubtedly, both approaches need to be considered in aetiological research. 13 The results for children include data from several paediatric registries, four of them with national coverage (five for leukaemias), and thus are based on a larger reference population than are those for adolescents. More registries contributed to the geographical comparisons than to the time trends.…”

Section: Discussionmentioning

confidence: 99%

Geographical patterns and time trends of cancer incidence and survival among children and adolescents in Europe since the 1970s (the ACCIS project): an epidemiological study

Steliarova‐Foucher

Stiller

Kaatsch³

et al. 2004

The Lancet

496

375

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The search for causes of the leukaemias

Cited by 9 publications

References 53 publications

Diagnosed hematological malignancies in Bangladesh - a retrospective analysis of over 5000 cases from 10 specialized hospitals

Diagnosed hematological malignancies in Bangladesh - a retrospective analysis of over 5000 cases from 10 specialized hospitals

Nationwide statistical analysis of myeloid malignancies in Korea: incidence and survival rate from 1999 to 2012

Geographical patterns and time trends of cancer incidence and survival among children and adolescents in Europe since the 1970s (the ACCIS project): an epidemiological study

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