The search for new herbicide mechanisms of action: Is there a ‘holy grail’?

Duke, Stephen O.; Dayan, Franck E.

doi:10.1002/ps.6726

Cited by 71 publications

(56 citation statements)

References 123 publications

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“…Historically, farmers have relied on new herbicide chemistries to deal with herbicide resistance (Heap and Duke 2018). Since the early 1980s, there has only been one new herbicide mode of action discovered (Duke and Dayan 2021). The compounding problems of herbicide resistance in weeds along with a lack of new effective herbicide modes of action has resulted in a greater need for a more diversified approach to weed management, including non-conventional methods of weed control (Norsworthy et al 2012;Bajwa et al 2015).…”

Section: Introductionmentioning

confidence: 99%

The impact of electrocution treatments on weed control and weed seed viability in soybean

2022

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Field experiments were conducted in 2020 and 2021 to determine the effectiveness of electrocution on several weeds commonly encountered in Missouri soybean production using an implement known as The Weed Zapper™. In the first study, the effectiveness of electrocution on waterhemp, cocklebur, giant and common ragweed, horseweed, giant and yellow foxtail, and barnyardgrass was determined. Electrocution was applied when plants reached average heights and/or growth stages of 30 cm, 60 cm, flowering, pollination, and seed set. Electrocution was applied once or twice, at two different tractor speeds. Electrocution was more effective at the later plant growth stages. Pearson correlation coefficients indicated that control of weed species was most related to plant height and amount of plant moisture at the time of electrocution. When plants contained seed at the time of electrocution, viability was reduced from 54 to 80% among the species evaluated. A second study determined the effect of electrocution on late-season waterhemp plants, and also soybean injury and yield. Electrocution timings took place throughout reproductive soybean growth stages. The control of waterhemp escapes within the soybean trial ranged from 51 to 97%. Yield of soybean electrocuted at the R4 and R6 growth stages were similar to the non-treated control, but soybean yield was reduced by 11 to 26% following electrocution at all other timings. However, the visual injury and yield loss observed in these experiments likely represents a worst-case scenario as growers that have a clear height differential between waterhemp and the soybean canopy would not need to maintain contact with the soybean canopy. Overall, results from these experiments indicate that electrocution as part of an integrated program could eliminate late-season herbicide-resistant weed escapes in soybean, and reduce the number and viability of weed seed that return to the soil seedbank.

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Section: Introductionmentioning

confidence: 99%

The impact of electrocution treatments on weed control and weed seed viability in soybean

2022

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“…Weeds can compete with crops and result in significant yield losses if they are not controlled 1 . The application of herbicides is the weed management strategy most commonly used by farmers and growers 2 . However, the selection pressure exerted by herbicides on weed populations can be intense, resulting in an increased abundance of genes conferring resistance to herbicides in weed populations 3,4 .…”

Section: Introductionmentioning

confidence: 99%

Inheritance of dicamba‐resistance in allotetraploid Chenopodium album

Ghanizadeh

Harrington

et al. 2022

Pest Management Science

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BACKGROUND Chenopodium album L. is a troublesome weed in spring‐planted crops, and different levels of ploidy have been documented for this weed species. A population of C. album has evolved resistance to dicamba. The level of ploidy and inheritance of dicamba resistance was studied in this population. RESULTS The resistant and susceptible individuals of C. album were confirmed as tetraploid by flow cytometry. Pair‐crosses were made between ten resistant and susceptible individuals. Eight F1 individuals from five crosses were confirmed resistant after treating with dicamba at 400 g a.e. ha−1. These individuals were selfed, and the response of their progenies to dicamba was assessed in dose–response experiments, and the results confirmed the resistance trait was dominant. Furthermore, an analysis of the segregation patterns revealed that the segregation response of all F2 progenies fitted a 3:1 (resistant/susceptible) ratio when treated with dicamba at 200, 400 and 800 g a.e. ha−1, suggesting a single gene was responsible for dicamba resistance. CONCLUSIONS Dicamba resistance in the studied tetraploid population of C. album is governed by a single dominant gene. This type of inheritance suggests that selection for dicamba resistance can occur readily. © 2022 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

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“…Some uncontrollable weeds damage crops and affect food safety with financial loss worth billions of dollars. As such, there is still a huge market gap in weed management that needs to be filled by expanding the diversity of HPPD-inhibiting herbicides as the innovative solution. , The growing availability of cryoelectronic and crystallographic microscopy, complemented with site-directed mutagenesis technologies and constructed homology models of the multi-species, motivated the researchers to improve the knowledge of substrate/ligand recognition within HPPD protein, thus providing solid foundations for the rational design of HPPD inhibitors …”

Section: Introductionmentioning

confidence: 99%

Pharmacophore-Oriented Discovery of Novel 1,2,3-Benzotriazine-4-one Derivatives as Potent 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors

Yan

Huang

et al. 2022

J. Agric. Food Chem.

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4-Hydroxyphenylpyruvate dioxygenase (HPPD) is a functional protein existing in almost all aerobic organisms. In the field of agricultural chemicals, HPPD is acknowledged to be one of the crucial targets for herbicides at present due to its unique bio-function in plants. In the Auto Core Fragment in silico Screening (ACFIS) web server, a potential HPPD inhibitor featuring 1,2,3-benzotriazine-4-one was screened out via a pharmacophore-linked fragment virtual screening (PFVS) method. Molecular simulation studies drove the process of “hit-to-lead” optimization, and a family of 1,2,3-benzotriazine-4-one derivatives was synthesized. Consequently, 6-(2-hydroxy-6-oxocyclohex-1-ene-1-carbonyl)-5-methyl-3-(2-methylbenzyl)benzo[d][1,2,3]triazin-4(3H)-one (15bu) was identified to be the best HPPD inhibitor (IC50 = 36 nM) among the 1,2,3-benzotriazine-4-one derivatives, which had over 8-fold improvement of enzyme inhibition compared with the positive control mesotrione (IC50 = 289 nM). Crystallography information for the AtHPPD–15bu complex revealed several important interactions of the ligand bound upon the target protein, i.e., the bidentate chelating interaction of the triketone motif with the metal ion of AtHPPD, a tight π–π stacking interaction consisting of the1,2,3-benzotriazine-4-one moiety and two benzene rings of Phe-424 and Phe-381, and the polydirectional hydrophobic contacts consisting of the ortho-CH3-benzyl group of the core scaffold and some hydrophobic residues. Furthermore, compound 15bu displayed 100% inhibition against the five species of target weeds at the tested dosage, which was comparable to the weed control of mesotrione. Collectively, the fused 1,2,3-benzotriazine-4-one-triketone hybrid is a promising chemical tool for the development of more potent HPPD inhibitors and provides a valuable lead compound 15bu for herbicide innovation.

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The search for new herbicide mechanisms of action: Is there a ‘holy grail’?

Cited by 71 publications

References 123 publications

The impact of electrocution treatments on weed control and weed seed viability in soybean

The impact of electrocution treatments on weed control and weed seed viability in soybean

Inheritance of dicamba‐resistance in allotetraploid Chenopodium album

Pharmacophore-Oriented Discovery of Novel 1,2,3-Benzotriazine-4-one Derivatives as Potent 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors

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