The Sedative and Analgesic Effects of Detomidine (Domosedan) in Donkeys

Abstract

Summary Detomidine (Domosedan) was administered to four groups of donkeys, using four different dosages (5, 10, 20 and 40μg/kg bwt) intravenously. The drug provided adequate sedation at dosages of 5 and 10 μg/kg bwt. Sedation deepened only slightly by increasing the dose. Analgesia was considered good with a dose of 20 μg/kg, and 40 μg/kg provided a deep analgesia associated with a longer duration. No significant changes had been observed in haematocrit (PCV), haemoglobin content (Hb%), total red and white cell counts and differential leucocytic counts. It was concluded that detomidine is a valuable sedative and analgesic drug to be used in donkeys without any serious implications.

Efeito sedativo da romifidina em muares (Equus asinus caballus) não domados

“…Enquanto que neste estudo, a sedação adequada foi obtida com 0,12mg/kg, estudos em eqüinos obtiveram efeitos satisfatórios com as doses de 0,04 e 0,08mg/kg (ENGLAND et al; HAMM et al, 1995). Os muares também parecem ser mais resistentes do que os asininos às drogas alfa2 agonistas, já que doses relativamente baixas de detomidina (0,005 e 0,010mg/kg) foram suficientes para induzir sedação em animais dessa espécie (MOSTAFA et al, 1995). Essas observações reforçam o relato de MATTHEWS et al (1997), que verificaram na prá-tica o fato de muares necessitarem de doses de drogas, alfa2 agonistas, aproximadamente 50% maiores de que as utilizadas em eqüinos e asininos.…”

Anaesthesia and analgesia of the donkey and the mule

“…Sedative and analgesic effects of detomidine have been described in donkeys by Mostafa et al . (1995).…”

“…Sedative and analgesic effects of detomidine have been described in donkeys by Mostafa et al (1995). 5-10 mg/kg bwt provided adequate sedation and 20-40 mg/kg bwt provided good to deep analgesia.…”

A comparative study of xylazine-induced mechanical hypoalgesia in donkeys and horses

“…xylazine, detomidine, medetomidine, and romifidine) are widely used in equine practice for their sedative and analgesic effects (Valverde 2010). A few studies have assessed the sedative effects of detomidine (Mostafa et al. 1995; El‐Maghraby & Atta 1997; Joubert et al.…”

“…2009). However, the scarce information on donkeys is of limited value since analgesia has only been assessed in non‐controlled studies by means of pinprick methods (Mostafa et al. 1995; Varshney et al.…”