The Selection of a Pharmaceutical Salt—The Effect of the Acidity of the Counterion on Its Solubility and Potential Biopharmaceutical Performance

4-[(Benzylamino)carbonyl]-1-methylpyridinium halogenide salts: X-ray diffraction study and Hirshfeld surface analysis

“…Many drugs are produced in the form of salts because of their higher solubility as compared to neutral compounds. The pharmacokinetic properties may be modified by the choice of counter-ion (Guerrieri et al, 2010;He et al, 2018). Therefore, the study of the ability of an active pharmaceutical ingredient to form salts with different ions is an actual problem.…”

Does the salt really matter? Impact of the counterion upon ECL signal

“…Counterions are vital within a range of substances but bare particular importance within the pharmaceutical industry, where they are utilized to improve the physiochemistry of active pharmaceutical ingredients. 6,7 Careful consideration is given to the counterion of choice, to ensure the required bioavailability is achieved, providing control over a drug's solubility, stability and dissolution rate. 6,7 However, the same consideration has not been given to the counterion during the developmental phase of any electrochemical analytical methodologies to date.…”

“…6,7 Careful consideration is given to the counterion of choice, to ensure the required bioavailability is achieved, providing control over a drug's solubility, stability and dissolution rate. 6,7 However, the same consideration has not been given to the counterion during the developmental phase of any electrochemical analytical methodologies to date. Traditionally, the counterion has been considered a bystander, bearing no influence upon the recorded ECL emission.…”

Formulation of aripiprazole-loaded pH-modulated solid dispersions via hot-melt extrusion technology: In vitro and in vivo studies

“…Various techniques are available to enhance the dissolution and bioavailability of poorly water-soluble drugs. Among those techniques that have been successful are nanoparticle formation Williams et al, 2018, Yousaf et al, 2016), particle size reduction (Jinno et al, 2006, Loh et al, 2015, salt formation (Grifasi et al, 2015, He et al, 2018, complexation with hydrophilic substances (Chi et al, 2015, Mennini et al, 2016, and solid dispersion (Huang and Dai, 2014, Rashid et al, 2015, Vasconcelos et al, 2007. Solid dispersions (SD) have shown to be one of the most successful ways to enhance the solubility and therefore, dissolution of drugs.…”