The selective effects of a monoclonal antibody against neural growth-related protein A3G7 on central mechanisms of several types of defensive behavior in adult rats

Шерстнев, В. В.; Pletnikov, Mikhail V.; Сторожева, З. И.; Proshin, A. T.

doi:10.1007/bf02461362

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…Similarly, the startle response was most significantly delayed both in male and in female pups exposed to 1.65G during early postnatal exposure. The delay in startle response may be related to a reduction in BDNF and NGF expression as has been previously suggested [49]. Motor coordination measured on a rotarod was most affected by early gestational exposure in both male and in female pups, with male pups having significantly shorter latency before falling off the rotarod.…”

Section: Alteration Of Cerebellar Bdnf and Ngf Depends On The Period mentioning

confidence: 76%

Cerebellar Brain-Derived Neurotrophic Factor, Nerve Growth Factor, and Neurotrophin-3 Expression in Male and Female Rats Is Differentially Affected by Hypergravity Exposure During Discrete Developmental Periods

Sajdel-Sulkowska

Koibuchi

2009

Cerebellum

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We previously reported that the effects of perinatal exposure to hypergravity on cerebellum and motor functions in rat neonates are strongly dependent on the specific developmental period of exposure. In the present study, we explored the hypothesis that neurodevelopmental changes are associated with altered expression of brain neurotrophins critical for normal brain growth and differentiation. We compared the effects of hypergravity exposure during four developmental periods: period I extended from gestational day (G) 8 through G15; period II from G15 to birth, period III from birth to postnatal day (P) 6; and period IV extended from G8-P12. For comparison we used stationary control (SC) neonates not exposed to hypergravity. Neurotrophins, brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and neurotrophin 3 (NT-3) levels were measured in cerebellar homogenates prepared from postnatal day 12 male and female rat neonates using specific ELISAs. Hypergravity exposure affected individual neurotrophins differently and the effect was further determined by the period of hypergravity exposure. ANOVA showed: (1) a significant effect of the period of exposure to hypergravity on cerebellar BDNF (p = 0.009), with maximal decrease of 28.7% in males and 32.1% in females following exposure during period III; (2) a significant effect on NGF (p < 0.0001), with maximal decrease of 35.6% in male and 48.8% in female neonates following exposure during period III; (3) no statistically significant effect on NT-3 expression with a trend towards decreased expression in female rats following exposure during period IV. Although the molecular mechanisms underlying the differential neurotrophins' response to hypergravity are not clear, an altered pattern of their expression is likely to contribute to neurodevelopmental changes and impaired sensorimotor behavior in exposed neonates.

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Section: Alteration Of Cerebellar Bdnf and Ngf Depends On The Period mentioning

confidence: 76%

Cerebellar Brain-Derived Neurotrophic Factor, Nerve Growth Factor, and Neurotrophin-3 Expression in Male and Female Rats Is Differentially Affected by Hypergravity Exposure During Discrete Developmental Periods

Sajdel-Sulkowska

Koibuchi

2009

Cerebellum

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“…This is supported by data showing that the effects of these factors on the formation, retention, and reproduction of various types of behavior are dosedependent. It should be noted that monoclonal antibodies against nerve growth protein A3G7 also had selective and dose-dependent effects on freezing behavior and extinction of the acoustic startle reaction in adult rats [8].…”

Section: Discussionmentioning

confidence: 99%

The involvement of neurotrophic factors in the central mechanisms of behavior in adult animals

Шерстнев

Сторожева²,

Gruden³

et al. 2000

Neurosci Behav Physiol

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In the light of the similarity of the neurochemical mechanisms of behavior during ontogenesis and in adult organisms, studies were performed on the effects of antibodies to neurotrophic factors--S-100b protein, CSL lectin, and R1 lectin-on the acquisition, retention, and reproduction of habituated acoustic startle reactions and freezing behavior in adult rats. Antibodies against neurotrophic factors were found to have selective, dose-dependent effects on the types of behavior investigated. Antibodies to S-100b, CSL, and R1, at a dose of 5 microg, induced derangements in the processes of consolidation and/or retention of behavioral habits. At a dose of 2 microg, antibodies to S-100b selectively blocked the retention of long-term habituation of the startle reaction, while a dose of 0.5 microg had no such effect. Antibodies to neurotrophic factors had no effect on reproduction of acquired defensive habits.

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The role of cellular development and cell death in neurochemical organization and integrative brain functions: Normal and pathological

Шерстнев¹

2004

Med pregl

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In terms of systemic aspects of common molecular mechanisms of development, important part of which is the process of cellular death and integrative activity of nervous system, a complex clinical-experimental study of effects of various neurotrophic and apoptotic factors (proteins S100b, HLDF, brain lectins CSL and R1) on learning and memory and ischemic stroke was performed. Data concerning specific and heterochronic participation of these factors in neurochemical mechanisms of learning and memory in mechanisms of ischemic stroke formation were established. Changes of examined factors and their antibodies as well as the dynamics of changes in sera and cerebrospinal fluid can be considered as prognostic markers of ischemic stroke and efficiency of therapy.

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The selective effects of a monoclonal antibody against neural growth-related protein A3G7 on central mechanisms of several types of defensive behavior in adult rats

Cited by 3 publications

References 8 publications

Cerebellar Brain-Derived Neurotrophic Factor, Nerve Growth Factor, and Neurotrophin-3 Expression in Male and Female Rats Is Differentially Affected by Hypergravity Exposure During Discrete Developmental Periods

Cerebellar Brain-Derived Neurotrophic Factor, Nerve Growth Factor, and Neurotrophin-3 Expression in Male and Female Rats Is Differentially Affected by Hypergravity Exposure During Discrete Developmental Periods

The involvement of neurotrophic factors in the central mechanisms of behavior in adult animals

The role of cellular development and cell death in neurochemical organization and integrative brain functions: Normal and pathological

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