The Selective Inhibitory Effect of Hyperthermia on the Metabolism and Growth of Malignant Cells

Vascular damage and delayed cell death in tumours after hyperthermia

“…The tumoricidal effect of hyperthermia has been related to an increase in immunological response (Mondovi et al, 1972;Muckle & Dickson, 1971;Sugaar & LeVeen, 1979 (Overgaard, 1978). We therefore feel that vascular damage is the primary cause of delayed cell death in tumours after hyperthermia.…”

Thermal radiosensitization in Chinese hamster (V79) and mouse C3H 10T 1/2 cells. The thermotolerance effect

“…Some of these differences may be related to variations in cell culture conditions since heat sensitivity could be influenced by the culture media and serum (Raaphorst and Azzam 1980). Differences may also be due to the nature of the cell since differences in the thermal sensitivity of normal and transformed or cancerous cells in culture have also been observed (Overgaard et al, 1977;Giovanella et al, 1976; Kase and Hahn, 1975;Muckle and Dickson, 1971). Furthermore, thermotolerance was found to influence cellular heat sensitivity and thermal radiosensitization (Henle et al, 1979;Sapareto et al, 1978;.…”

Combined treatment of a solid tumour by local hyperthermia and actionomycin D

“…Hyperthermia is more deleterious to malignant than to normal tissue (Kim, Kim and Hann, 1974;Muckle and Dickson, 1971;Dickson and Suzangar, 1976). Hyperthermal enhancement of the sensitivity of cancer cells to ionizing radiation has been demonstrated in humans (Selawry, Carlson and Moor, 1958;Cocket et al, 1967;Shoulders et al, 1942;Warren, 1935;Brenner and Yerushalmi, 1975), in experimental implanted tumours (Robinson, Wizenberg and McCready, 1974;Crile, 1963;Hahn, Alfieri and Kim, 1974;Yerushalmi, 1975Yerushalmi, , 1976a and in cells in culture (Chen and Heidelberger, 1969;Ben-Hur, Elkind and Bronk, 1974).…”