The selective mGlu2/3 receptor antagonist LY341495 exacerbates behavioral signs of morphine withdrawal and morphine-withdrawal-induced activation of locus coeruleus neurons

Rasmussen, Kurt; Hsu, Mei-Ann; Vandergriff, Jim

doi:10.1016/j.neuropharm.2003.11.013

Cited by 28 publications

(14 citation statements)

References 41 publications

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“…With regard to the latter two signs reduced by the GCP II inhibitor, one may hypothesize that the diminution of glutamatergic tone associated with 2-MPPA administration attenuates some indices of naloxone-precipitated opioid withdrawal, as have been reported for other inhibitors of glutamatergic neurotransmission (e.g., Jhamandas et al 1996;Fundytus and Coderre 1997;Klodzinska et al 1999;Palucha et al 2004). The fact that the intensity of ptosis was increased by LY341495 is also consistent with the study of Rasmussen et al (2004). The authors reported that the mGluR2/3 antagonist LY341495 augmented various signs of opioid withdrawal in rats.…”

Section: Discussionsupporting

confidence: 83%

2-MPPA, a selective glutamate carboxypeptidase II inhibitor, attenuates morphine tolerance but not dependence in C57/Bl mice

et al. 2005

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Section: Discussionsupporting

confidence: 83%

2-MPPA, a selective glutamate carboxypeptidase II inhibitor, attenuates morphine tolerance but not dependence in C57/Bl mice

et al. 2005

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“…Naloxone administration following chronic injections of morphine induced behavioral signs of withdrawal in rats, which is in agreement with other studies (Rasmussen et al, 2004;Dizgah et al, 2005).…”

Section: Discussionsupporting

confidence: 93%

Attenuation of morphine withdrawal signs by muscimol in the locus coeruleus of rats

Mirzaii‐Dizgah

Karimian

Hajimashhadi

et al. 2008

Behavioural Pharmacology

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This study examined the effects of intra-locus coeruleus injection of a gamma-amino-butyric acid type A (GABAA) receptor agonist on naloxone-induced withdrawal signs of morphine-dependent rats. Twenty different withdrawal signs were assessed. The total withdrawal score was calculated and used as an index of withdrawal intensity. The gamma-amino-butyric acid agonist and antagonists were injected 15 and 30 min before naloxone injection, respectively. Muscimol, a GABAA agonist (25, 50, and 100 ng/site), decreased the total withdrawal score in a dose-independent manner, whereas bicuculline (0.367, 3.67, and 36.7 ng/site), a GABAA antagonist, and CGP35348 (48.6 ng/site), a gamma-amino-butyric acid type B antagonist, alone had no effects. On the other hand, muscimol effects were reversed by CGP35348 (48.6 ng/site) but not by bicuculline (36.7 ng/site). It may be concluded that the effects of muscimol were antagonized by gamma-amino-butyric acid type B but not by GABAA receptor antagonists. The mechanism involved seems to be intricate and needs further study.

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“…First, MK-801 ([+]-5-methyl-10,11,dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate; Sigma-Aldrich; 0.2 mg/kg IP) was used to block NMDA receptors known to exist in the olfactory system (Wilson et al 1996). Second, LY341495 (Tocris Bioscience; 2.5 mg/kg IP), a metabotropic glutamate receptor II/III antagonist capable of crossing the blood-brain barrier (O'Neill et al 2003;Rasmussen et al 2004), was used to block the activity of mGluR II/III metabotropic glutamate receptors in the olfactory system (Best and Wilson 2004).…”

Section: Pharmacologymentioning

confidence: 99%

Distinct neural mechanisms mediate olfactory memory formation at different timescales

McNamara¹,

Magidson²,

Linster³

et al. 2008

Learn. Mem.

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Habituation is one of the oldest forms of learning, broadly expressed across sensory systems and taxa. Here, we demonstrate that olfactory habituation induced at different timescales (comprising different odor exposure and intertrial interval durations) is mediated by different neural mechanisms. First, the persistence of habituation memory is greater when mice are habituated on longer timescales. Second, the specificity of the memory (degree of cross-habituation to similar stimuli) also depends on induction timescale. Third, we demonstrate a pharmacological double dissociation between the glutamatergic mechanisms underlying short-and long-timescale odor habituation. LY341495, a class II/III metabotropic glutamate receptor antagonist, blocked habituation only when the induction timescale was short. Conversely, MK-801, an N-methyl-D-aspartate (NMDA) receptor antagonist, prevented habituation only when the timescale was long. Finally, whereas short-timescale odor habituation is mediated within the anterior piriform cortex, infusion of MK-801 into the olfactory bulbs prevented odor habituation only at longer timescales. Thus, we demonstrate two neural mechanisms underlying simple olfactory learning, distinguished by their persistence and specificity, mediated by different olfactory structures and pharmacological effectors, and differentially utilized based solely on the timescale of odor presentation.Habituation, or the progressive reduction in behavioral responsiveness to repeated similar stimuli, is a simple form of learning that underlies animals' capacity to perceptually deemphasize static conditions or inconsequential stimuli in favor of novel, potentially more relevant environmental features or events (Thompson and Spencer 1966;Rose and Rankin 2001). In the laboratory, experimental paradigms based on habituation have been employed to study the properties of nonassociative perceptual learning, to measure the persistence of memory traces, and even to assess the stringency of spontaneous discrimination among similar stimuli. In studies of olfactory spontaneous discrimination using rats or mice, animals habituated to an odorant stimulus demonstrate a cross-habituation response to novel odorant stimuli that are structurally and perceptually similar to the habituated odorant. The degree of cross-habituation declines progressively as test odorants become more dissimilar, and habituation to both the original and cross-habituated odorant stimuli persists for at least several minutes (Cleland et al. 2002;Linster et al. 2002; Mandairon et al. 2006b,c).Olfactory habituation has also been observed in studies in which it is attributed to rapid synaptic adaptation of the mitrapyramidal synapse in the rat anterior piriform cortex (aPC) (Best and Wilson 2004;Yadon and Wilson 2005). Odor-evoked activity in piriform pyramidal neurons adapts within tens of seconds, and this adaptation persists for up to 2 min (Wilson 1998a,b), a substantially faster timescale than that exhibited in the behavioral studies discussed above. Further...

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The selective mGlu2/3 receptor antagonist LY341495 exacerbates behavioral signs of morphine withdrawal and morphine-withdrawal-induced activation of locus coeruleus neurons

Cited by 28 publications

References 41 publications

2-MPPA, a selective glutamate carboxypeptidase II inhibitor, attenuates morphine tolerance but not dependence in C57/Bl mice

2-MPPA, a selective glutamate carboxypeptidase II inhibitor, attenuates morphine tolerance but not dependence in C57/Bl mice

Attenuation of morphine withdrawal signs by muscimol in the locus coeruleus of rats

Distinct neural mechanisms mediate olfactory memory formation at different timescales

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