The Selectivity of the Human Placenta in the Transfer of Plasma Proteins from Mother to Fetus*

Gitlin, David; Kumate, J; Urrusti, Juan; Morales, Carlos R.

doi:10.1172/jci105068

Cited by 259 publications

(43 citation statements)

References 28 publications

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“…For transferrin, this amount was between 0.34% and 0.49% of its serum concentration. For IgG, it was 0.16%, Active transport of IgG across the BAB is conceivable, as has been found in the placenta (Brambell et al, 1960;Gitlin, et al, 1964), but a local synthesis seems more likely. The injection of heterologous proteins into the rabbit's vitreous body results in the infiltration of the uvea by lymphocytes and immunoglobulin-secreting plasmocytes which may be recognized by immunofluorescence (Witmer, 1955a;B6ke, 1965;Dieckhues, 1965Dieckhues, -1967.…”

Section: Ap Dpmentioning

confidence: 59%

“…If this epithelium was responsible for the sieve effect, it would be necessary to accept a transcytoplasmic pathway, because cytologists think that the tight junctions are hermetically sealed (Staehelin, 1974;Berkallof et al, 1977). A transcytoplasmic transfer is accepted for IgG across placenta (Brambell et al, 1960;Gitlin et al, 1964), and for IgA and IgM across enterocytes (Brown et al, 1977) and hepatocytes (Jackson et al, 1978;Orlans et al, 1978;Fisher et al, 1979). In the experiments already cited, cytoplasmic peroxidase-filled vesicles were observed in the inner (non-pigmented) cell layer of the epithelium.…”

Section: Location Of the Molecular Sievementioning

confidence: 99%

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The proteins of the aqueous humour

Dernouchamps

1982

Doc Ophthalmol

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Section: Ap Dpmentioning

confidence: 59%

Section: Location Of the Molecular Sievementioning

confidence: 99%

The proteins of the aqueous humour

Dernouchamps

1982

Doc Ophthalmol

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“…Serum albumin concentrations increase with gestational age. Possible explanations for this could be increased synthesis by the fetal liver [23] or the greater placental transfer of albumin towards term [24]. Serum levels of albumin may fall during periods of stress, trauma, or sepsis [25] despite its long half-life of 17-19 days [22].…”

Section: Discussionmentioning

confidence: 99%

Hypoalbuminemia in Donors with Twin Anemia-Polycythemia Sequence: A Matched Case-Control Study

et al. 2013

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Objective: To determine the differences in albumin levels between donors and recipients with twin anemia-polycythemia sequence (TAPS). Methods: We included all consecutive monochorionic twins with TAPS with double survivors. Each twin pair was matched for gestational age at birth with 2 control monochorionic twin pairs unaffected by TAPS or twin-twin transfusion syndrome. We measured levels of albumin, total protein, and hemoglobin on the first day of life in donors and recipients (TAPS group) and the control group. Results: A total of 25 TAPS twin pairs and 50 control twin pairs were included in the study. The median gestational age at birth was 32 weeks in both groups. In the TAPS group, median levels (IQR) of albumin in donor twins were significantly lower than in recipient twins, i.e. 28.0 g/l (24.0-32.0) versus 32.0 g/l (30.0-34.5) (p = 0.008). Median levels (IQR) of total protein in donor twins were also lower than in recipients, i.e. 44.0 g/l (36.5-49.0) versus 49.0 g/l (46.5-51.0), respectively (p = 0.004). The median (IQR) intertwin albumin difference was significantly higher in the TAPS group than in the control group, i.e. 4.0 g/l (2.5-10.5) versus 2.0 g/l (1.0-4.0) (p = 0.003). The rate of hypoalbuminemia (<20 g/l) and hypoproteinemia (<40 g/l) in donor twins with TAPS was 20% (5/25) and 32% (8/25). Conclusions: In addition to lower hemoglobin levels, donor twins with TAPS also have significantly lower albumin and total protein levels compared to recipient twins.

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“…Strong evidence has been obtained that transferrin itself does not cross the placenta (Rausen, Gerald & Diamond, 1961;Gitlin et al, 1964;Fletcher & Suter, 1969;Shott & Andrews, 1972).…”

Section: Discussionmentioning

confidence: 99%

“…In these species, the maternal plasma is the only important source of iron for the foetus and transport across the placenta is an extremely rapid process, against a concentration gradient (Bothwell, Pribilla, Mebust & Finch, 1958;Fletcher & Suter, 1969;Mansour, Schulert & Glasser 1972;Wong & Morgan, 1973). As the rate of irot ransfer is far greater than that of transferrin (Morgan, 1964;Gitlin, Kumate, Urrusti & Morales, 1964;Masters, Bignold & Morgan, 1969;Baker & Morgan, 1970), placental iron transfer must involve dissociation of the maternal transferrin-iron complex, followed by passage of iron through the placenta and subsequent binding to foetal transferrin at the foetal side of the placenta.…”

Section: Introductionmentioning

confidence: 99%

Isolation, Characterization and Function of Cord-Blood Transferrin

Verhoef

Eijk

1975

Clinical Science

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1. Transferrin was isolated from umbilical cord blood by means of gel filtration on Sephadex G-150 and ion exchange chromatography on DEAE-Sephadex A-50, and its properties were compared with those of transferrin isolated from human adult blood. 2. Both glycoproteins were able to bind a maximum of two atoms of iron per molecule and have very similar amino acid and carbohydrate compositions. 3. The molecular weight of cord-blood transferrin, assessed by equilibrium centrifugation, was 78200, and its sedimentation velocity appeared to be 5-2S. 4. Cord-blood transferrin and adult blood transferrin were found to be immunochemically identical. 5. No differences could be detected between the transferrins in their capacities to deliver iron to immature erythrocytes derived from rat bone marrow, which indicates that the rapid transport of iron across the placenta cannot be explained by differences between foetal and maternal transferrin.

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The Selectivity of the Human Placenta in the Transfer of Plasma Proteins from Mother to Fetus*

Cited by 259 publications

References 28 publications

The proteins of the aqueous humour

The proteins of the aqueous humour

Hypoalbuminemia in Donors with Twin Anemia-Polycythemia Sequence: A Matched Case-Control Study

Isolation, Characterization and Function of Cord-Blood Transferrin

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