“…These include (1) speed and quality of clustering; (2) the number of clusters; (3) the updating procedure for the output neurons; and (4) the learning rate in the SOM model. Recent work in applying the SOM model and its suggested variants (Cuadros-Vargas and Romero, 2002;Guo et al, 2003;Skupin and Fabrikant, 2003;Guo et al, 2004;Yang et al, 2003;Bação et al, 2004Bação et al, , 2005Huang et al, 2005;Cuadros-Vargas and Romero, 2005;Oyana et al, 2005a, b;Guo et al, 2006) have significant implications with regards to how we extract relevant information or gain fundamental insights from very large-scale datasets. These studies along with this one could be valuable in advancing our understanding of the biomedical and epidemiological processes of diseases in relation to space and time.…”