The sequence of appearance of antibodies in mouse omentum plasma cells

Omental Milky Spots Develop in the Absence of Lymphoid Tissue-Inducer Cells and Support B and T Cell Responses to Peritoneal Antigens

“…Previous work suggested that the omentum had an immunological function and showed that plasma cells could be found in the omentum after intraperitoneal immunization with T-independent antigens (Ansel et al, 2002; Ha et al, 2006) as well as classic T-dependent antigens (Dux et al, 1977; Hajdu et al, 1972; Van Vugt et al, 1996). Nevertheless, some authors have concluded that the MS should not be classified as secondary lymphoid organs (Szaniawska, 1974; Szaniawska, 1975; Van Vugt et al, 1996).…”

“…Plasma cell responses to some T-dependent antigens are observed in the omenta of mice immunized i.p. (Dux et al, 1977; Dux et al, 1986; Hajdu et al, 1972) and the surgical removal of the omentum in rabbits reduces the antibody response to i.p. SRBC by 75% (Portis, 1924), suggesting that the MS may be secondary lymphoid organs.…”

Changes in the fine structure of the dental pulp in human caries pulpitis

“…The functional activity of the plasma cells, at least fr-om a morphological point of view, was of particular interest in this study. Earlier studies have shown that the synthesis of antibodies takes place in the rough endoplasmic retieulum of plasma cells (Hajdu et al 1972, de Petris & Karlsbad 1965, de Petris et al 1963) and that synthesis occurs in associatior-i with cell maturatior-r and not following it (de Petris & Karlsbad 1965, Ortega & Mellors 1957. From their morphologieal appearance, it is highly prob-able that the plasma cells present in earies pulpitis were engaged in the synthesis of antibodies.…”

“…The morphological characteristics of the plasma cells in this investigation may also letid some insight into the mechanisms by which antibodies ate released into the extraeellular environment. It is generally accepted that antibodies are produced by endoplasmic reticulum and that they ate stored in the cisternae of this reticulum and in the cisternae about the cell nucleus (Hajdu et al 1972, de Petris & Karlsbad 1965. The Golgi apparatus has been associated witb the excretion of antibody by the formation of Golgi derived vesicles and the process of reverse pinocytosis (Hajdu et al 1972).…”

“…It is generally accepted that antibodies are produced by endoplasmic reticulum and that they ate stored in the cisternae of this reticulum and in the cisternae about the cell nucleus (Hajdu et al 1972, de Petris & Karlsbad 1965. The Golgi apparatus has been associated witb the excretion of antibody by the formation of Golgi derived vesicles and the process of reverse pinocytosis (Hajdu et al 1972). While such a mode of antibody release is still eontentious, a second method, by apocrine secretion through a clasmatosis, or pinching off, of peripheral portions of eytoplasm containing one or more distended cisternae of rough endoplasmie reticulum, has reeeived recent attention (Garant & Mulvihill 1972, Hajdu et al 1972, Weinstoek 1968.…”