The Seroprevalence of Cytomegalovirus Antibodies among Prospective Blood Donors in Jos

Alao, OO; Joseph, DE; Mamman, Aisha Indo; Banwat, E. B.

doi:10.4314/njm.v17i2.37383

Cited by 15 publications

(22 citation statements)

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“…Nearly similar results were reported in previous studies which revealed that CMV seroprevalence ranged from 92-97% (26)(27)(28)(29)(30). Lower rates of 52.5%, 67.4% and 83.4% were reported in Egypt by Mourad et al, Mussa et al, and El-Saady (17,31,32).…”

Section: Discussionsupporting

confidence: 79%

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Cytomegalovirus Immunoglobulin G Avidity Index among Blood Donors in Alexandria, Egypt

Gawad

Hashish

Abaza

et al. 2016

Cent Eur J Public Health

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SUMMARYBackground and Aim: Transfusion transmitted diseases (TTD) are a major challenge to transfusion services all over the world. Cytomegalovirus (CMV) is considered one of the main viruses associated with blood transfusion. As CMV screening is not included in routine screening tests done for donated blood in blood banks in Egypt, the detection of CMV Immunoglobulin G (IgG) avidity needs to be tested for being a useful tool to diagnose recent infection among blood donors. The aim of this work was to study CMV IgG avidity index (AI) among blood donors.Methods: A total of 88 blood samples were collected from the non-remunerated volunteer blood donors who attended the Alexandria Regional Blood Transfusion Centre. A quantitative enzyme linked immunosorbent assay for the avidity detection of the specific IgG antibodies to CMV in human serum samples was used.Results: Eighty five studied blood donors (96.6%) were positive for CMV IgG. Eighty one donors (95.3%) showed high avidity (> 45.0%). Regarding the remaining four CMV IgG positive donors; three had medium avidity (< 45.0%) and only one had a low avidity of < 25.0%. A moderate agreement of 42.4% was found between IgG concentration and avidity.Conclusions: CMV seroprevalence was found to be high among volunteer blood donors, where age and gender were statistically significant factors associated with CMV IgG concentration. The use of the avidity assay as a screening tool for CMV among blood donors is highly suggested. The exclusion of the low and medium AI units will ensure the availability of a safe stock of blood units, hence eliminating the risk of CMV transmission to vulnerable groups.

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Section: Discussionsupporting

confidence: 79%

“…CMV was lowest in the extremes of age (26). In Egypt, El-Saady noted that the highest percentage was in the age group of 20-29 years (32).…”

Section: Discussionmentioning

confidence: 99%

Cytomegalovirus Immunoglobulin G Avidity Index among Blood Donors in Alexandria, Egypt

Gawad

Hashish

Abaza

et al. 2016

Cent Eur J Public Health

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“…The seropositive rate reported in this study is lower than prevalence rates observed in previous studies carried out in other parts of Nigeria. It was 92% in Jos (Alao et al, 2008), 95.8% in Benin (Ojide et al, 2012), and 96% in Lagos (Akinbami et al, 2009) prevalence.…”

Section: Resultsmentioning

confidence: 91%

The Prevalence of Cytomegalovirus among Eligible Blood Donors in Keffi, Nigeria

Pennap¹,

Joseph²,

Oti³

2016

Int.J.Curr.Microbiol.App.Sci

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“…The high seroprevalence of CMV that was discovered suggests that there is a wide circulation of the virus in the Bahia State; however, this prevalence is consistent with other Brazilian, as well as worldwide, studies. For example, serological surveys among blood donors showed the following regional CMV seroprevalences: 87.9% in Brazil [Matos et al, 2010], 93.2% in Ghana [Adjei et al, 2006], 95% in India [Kothari et al, 2002], 97.2% in Turkey [Mutlu et al, 2008], 92% in Nigeria [Alao et al, 2008], 97.14% in Tunisia [Gargouri et al, 2000], 69.8% in Spain [Rojo et al, 1992], and between 35.5% and 45.8% in the USA [Hecker et al, 2004; Boeke et al, 2008].…”

Section: Discussionmentioning

confidence: 99%

Rapid gynogenetic mapping of Xenopus tropicalis mutations to chromosomes

Khokha

Krylov

Reilly

et al. 2009

Developmental Dynamics

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Pilot forward genetic screens in Xenopus tropicalis have isolated over 60 recessive mutations. Here we present a simple method for mapping mutations to chromosomes using gynogenesis and centromeric markers. When coupled with available genomic resources, gross mapping facilitates evaluation of candidate genes as well as higher resolution linkage studies. Using gynogenesis, we have mapped the genetic locations of the 10 X. tropicalis centromeres, and performed fluorescence in situ hybridization to validate these locations cytologically. We demonstrate the use of this very small set of centromeric markers to map mutations efficiently to specific chromosomes.

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The Seroprevalence of Cytomegalovirus Antibodies among Prospective Blood Donors in Jos

Cited by 15 publications

References 0 publications

Cytomegalovirus Immunoglobulin G Avidity Index among Blood Donors in Alexandria, Egypt

Cytomegalovirus Immunoglobulin G Avidity Index among Blood Donors in Alexandria, Egypt

The Prevalence of Cytomegalovirus among Eligible Blood Donors in Keffi, Nigeria

Rapid gynogenetic mapping of Xenopus tropicalis mutations to chromosomes

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