The serum levels of insulin and igf-i in newborn piglets treated with clinoptilolite

Stojić, Velibor; Gvozdić, Dragan; Nikolić-Judith, Anna; Šamanc, Horea; Jovanović, Ivan; Tomašević-Čanović, Magdalena; Vujanac, Ivan

doi:10.2298/avb0304219s

Cited by 8 publications

(1 citation statement)

References 25 publications

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“…et al showed a positive relationship between ALP and blood sugar, 34 thus higher levels of ALP among diabetic groups than NC were expected in the current study. The additive effect of CLN on higher levels of insulins 35 was expected to decrease glucose levels in the diabetic-control group more than the normal-control.…”

Section: Discussionmentioning

confidence: 99%

The effects of natural nano-sized clinoptilolite and Nigella sativa supplementation on serum bone markers in diabetic rats

et al. 2019

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Introduction: Many studies confirm that diabetes mellitus is associated with higher risks of bone fracture. The beneficial effects of Nigella sativa (NS) and clinoptilolite in preventing/reducing some diabetes-related disorders have been shown. This study was conducted to examine the effects of separate and concurrent supplementation of natural nano-sized clinoptilolite (NCLN) and NS on serum bone markers in rats with type 2 diabetes. Methods: A total of 42 (case=36 and control=6) adult male Wistar rats were divided into 2 groups: diabetic and non-diabetic. An oral glucose tolerance test and a homeostatic model assessment of insulin resistance (HOMA-IR) test were conducted to confirm diabetes. Then, the diabetic group was divided into 4 subgroups: [1] control (n=9), [2] NS 1%/food (n=9), [3] NCLN 2%/food (n=9), [4] NS 1%/food + NCLN 2%/food (n=9). After 7 weeks, serum levels of bone markers were determined using ELISA kits. Results: Analysis showed that serum levels of alkaline phosphatase (ALP) in the NCLN group (1318.6 ± 217.5 U/L) was significantly (P<0.05) higher than other intervented groups. On the other hand, serum levels of calcium in NCLN+NS group (10.8 ± 2.6 mg/dL) were higher (P=0.027) compared to all other study groups. However, rats in the NS group had higher (535.8 ± 49.3 pg/mL) PTH (P<0.0001) compared to other supplementation groups. There were no significant differences in vitamin D and osteoprotegerin. Conclusion: The results of the current study suggest that bone mineralization may be affected by concurrent use of NS and NCLN through influencing calcium circulation. Moreover, dietary NS administration is strongly related to an augmented level of PTH.

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Section: Discussionmentioning

confidence: 99%

The effects of natural nano-sized clinoptilolite and Nigella sativa supplementation on serum bone markers in diabetic rats

et al. 2019

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Design and fabrication of clinoptilolite–nanohydroxyapatite/chitosan–gelatin composite scaffold and evaluation of its effects on bone tissue engineering

Sadeghinia

Soltani

Aghazadeh

et al. 2019

J Biomedical Materials Res

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The aim of this study was to synthesize an innovative composite scaffold, which structured of clinoptilolite-nanohydroxyapatite/chitosan-gelatin (CLN-nHA/CS-G) with enhanced attributes for utilization in the bone tissue engineering. This composite scaffold was prepared by blending the CLN, nHA, chitosan, and gelatin solution followed by a freeze-drying step. The fabricated composite scaffolds were studied using BET, FTIR, XRD, and SEM techniques. The highly porous composite scaffolds with a pore size of 200 ± 100 μm were synthesized. Moreover, the effects of CLN and nHA on the physicochemical features of the scaffold such as density, swelling ratio, biomineralization, biodegradation, and mechanical behavior were studied. Compared with CS-G scaffold, the presence of CLN and nHA leads to an increased surface area, increased biomineralization, and low rate of degradation in simulated body fluid solution (SBF) and mechanical strength. Cytotoxicity of the CLN-nHA/CS-G scaffold was studied by MTT assay on human dental pulp stem cells (h-DPSCs). The biological response of h-DPSCs showed no toxicity and studied cells proliferated and attached on the pore surfaces of the scaffold. Results indicated that introducing CLN and nHA to composite improves the scaffold characteristics in a way that makes it suitable for bone tissue engineering. K E Y W O R D Sbone tissue engineering, chitosan, clinoptilolite, scaffold, stem cells

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Thyroid gland hormones in newborn calves treated with clinoptilolite receiving different amounts of colostrum

Stojić¹,

Gvozdić²,

Šamanc³

et al. 2005

Acta vet. (Beogr.)

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The aim of this study was to investigate the influence of the natural mineral adsorber clinoptilolite on serum levels of thyroid hormones in newborn calves in the first 48 hours postpartum. A total number of 68 newborn Holstein calves divided in four groups were used in the present study. Calves were randomly assigned to one of the following treatments: 1) 0.75 L of colostrum in 12h intervals, with 5 g/L of clinoptilolite immediately after birth (Oh) at 12h and 24h after birth (0.75+); 2) 0.75L of colostrum in 12h intervals (0.75-), which represents the first control group; 3) 1.5L of colostrum in 12h intervals, with 5 g/L of clinoptilolite immediately after birth (Oh), at 12h and 24h after birth (1.5+), and 4) 1.5 L of colostrum in 12h intervals (1.5-), which represents the second control group. The calves were born with high blood serum thyroid hormones concentrations (9.7-13.5 nmol/L for T3 and 201-235 nmol/L for T^. At 6. hours after birth serum thyroid hormone levels increased in all groups, but become significantly lower at 48. hours after birth. Clinoptilolite treatment could influence the rise in blood serum thyroid hormones concentration during the early postnatal period. This was most evident in the treated group of calves that received 1.5 L of colostrum (T3, 6h, 11.7±3.4:19.4±7.4, p<0.01; 1.5+ vs. 1.5-). Results indicate that there is a possible effect of clinoptilolite treatment on blood serum thyroid hormones concentration in newborn calves during the first 48 hours of life

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The serum levels of insulin and igf-i in newborn piglets treated with clinoptilolite

Cited by 8 publications

References 25 publications

The effects of natural nano-sized clinoptilolite and Nigella sativa supplementation on serum bone markers in diabetic rats

The effects of natural nano-sized clinoptilolite and Nigella sativa supplementation on serum bone markers in diabetic rats

Design and fabrication of clinoptilolite–nanohydroxyapatite/chitosan–gelatin composite scaffold and evaluation of its effects on bone tissue engineering

Thyroid gland hormones in newborn calves treated with clinoptilolite receiving different amounts of colostrum

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