The Serum S100B Concentration Is Age Dependent

Portela, Luis Valmor; Tort, Adriano Bretanha Lopes; Schaf, Débora Vigevani; Ribeiro, Luciana; Nora, Daniel Bocchese; Walz, Roger; Rotta, Liane Nanci; Silva, Cátia T.; Busnello, João Vicente; Kapczinski, Flávio; Gonçalves, Carlos Alberto; Souza, Diogo Onofre Gomes de

doi:10.1093/clinchem/48.6.950

Cited by 132 publications

(54 citation statements)

References 21 publications

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“…The test can detect protein S100B concentrations ranging from 5 to 39,000 ng/L with inter‐ and intra‐assay coefficient of variation of 5.6% and 2.3%. Postablation increase of S100B above the upper reference limit of 105 ng/L (the 95th percentile value in a healthy population) was regarded as an evidence of periprocedural acute brain injury.…”

Section: Methodsmentioning

confidence: 99%

A Novel Biomarker‐Based Approach for the Detection of Asymptomatic Brain Injury During Catheter Ablation of Atrial Fibrillation

Šramko¹,

Peichl²,

Wichterle³

et al. 2013

Cardiovasc electrophysiol

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Section: Methodsmentioning

confidence: 99%

A Novel Biomarker‐Based Approach for the Detection of Asymptomatic Brain Injury During Catheter Ablation of Atrial Fibrillation

Šramko¹,

Peichl²,

Wichterle³

et al. 2013

Cardiovasc electrophysiol

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“…Interictal serum levels of S100B protein were measured in 39 epileptic patients: 20 with epilepsy associated to chronic NCC (NCC group) and 19 with epilepsy without NCC (EPI group). They were followed at the Policlínica Regional – SUS, Florianópolis, SC, southern Brazil, and were compared with 20 healthy blood donors (CON group) matched by age and sex (18). Epileptic patients were matched by age, sex, age of epilepsy onset (considered the age that patients started the recurrent epileptic seizure), epilepsy duration, frequency of seizures, interictal electroencephalographic (EEG) abnormalities, seizure types, and anti‐epileptic drug (AED) used.…”

Section: Methodsmentioning

confidence: 99%

Interictal serum S100B levels in chronic neurocysticercosis and idiopathic epilepsy

Portela

Tort

Walz

et al. 2003

Acta Neurologica Scandinavica

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“…7,33,49,55,56 Only one paper has reported that schizophrenic men had higher levels of S100B than schizophrenic women. 50 In healthy subjects, S100B plasma levels have been reported as not correlated to age 23,49,50 as well as having a positive correlation with age. 62 In patients with schizophrenia, no link between age and serum levels of S100B has been reported, 7,16,21,49,50,55,56,61 although others have found a positive correlation between age and S100B serum levels.…”

Section: Serum S100b and Schizophreniamentioning

confidence: 99%

“…Such high levels in infants may be linked to neurodevelopmental processes as well as glial cell maturation and synapse formation. 23 The possible neurotrophic activity of S100B has been pointed out in research, showing a positive correlation between S100B levels in umbilical cord and brain maturation. 24 As it is considered that normal levels of S100B exclude major pathology of the CNS, S100B levels have been used as a prognostic factor in cases of minor brain damage.…”

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confidence: 98%

S100B and schizophrenia

Yelmo-Cruz

Fumero

Abreu-González

2013

Psychiatry Clin Neurosci

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The research for peripheral biological markers of schizophrenia, although abundant, has been unfruitful. In the last 2 decades, the S100B protein has made its own room in this area of research. S100B is a calcium-binding protein that has been proposed as a marker of astrocyte activation and brain dysfunction. Research results on S100B concentrations and schizophrenia clinical diagnosis are very consistent; patients with schizophrenia have higher S100B concentrations than healthy controls. The results regarding schizophrenia subtypes and clinical characteristics are not as conclusive. Age of patients, body mass index, illness duration and age at onset have been found to show no correlation, a positive correlation or a negative correlation with S100B levels. With respect to psychopathology, S100B data are inconclusive. Positive, negative and absence of correlation between S100B concentrations and positive and negative psychopathology have been reported. Methodological biases, such as day/night and seasonal variations, the use of anticoagulants to treat biological samples, the type of analytical technique to measure S100B and the different psychopathological scales to measure schizophrenia symptoms, are some of the factors that should be taken into account when researching into this area in order to reduce the variability of the reported results. The clinical implications of S100B changes in schizophrenia remain to be elucidated.

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The Serum S100B Concentration Is Age Dependent

Cited by 132 publications

References 21 publications

A Novel Biomarker‐Based Approach for the Detection of Asymptomatic Brain Injury During Catheter Ablation of Atrial Fibrillation

A Novel Biomarker‐Based Approach for the Detection of Asymptomatic Brain Injury During Catheter Ablation of Atrial Fibrillation

Interictal serum S100B levels in chronic neurocysticercosis and idiopathic epilepsy

S100B and schizophrenia

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