2021
DOI: 10.1016/j.wjorl.2020.02.002
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The serum squamous cell carcinoma antigen level in inverted sinonasal papilloma and nasal polyps patients

Abstract: Objective To clarify whether the serum squamous cell carcinoma antigen (SCCA) levels of patients with inverted papilloma (IP) are different from patients with nasal polyps (NP) and rhinitis. Materials and methods Serum SCCA levels were measured in 30 patients with IP and 30 patients with NP at one day before surgery and seven days after surgery and measured in 28 patients with rhinitis. Results Elevated serum SCCA levels (>1.5 ng/ml) were fou… Show more

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Cited by 8 publications
(7 citation statements)
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“…Notably, SCCA-1 levels showed a postoperative decline in both IP and CRS patients, which is consistent with previous retrospective studies [15][16][17][18][19][20]27], whereas SCCA-2 levels remain relatively stable in those patients postoperatively. These findings underscore the critical importance of SCCA-1 measurement in the preoperative diagnosis of IP.…”
Section: Discussionsupporting
confidence: 91%
See 1 more Smart Citation
“…Notably, SCCA-1 levels showed a postoperative decline in both IP and CRS patients, which is consistent with previous retrospective studies [15][16][17][18][19][20]27], whereas SCCA-2 levels remain relatively stable in those patients postoperatively. These findings underscore the critical importance of SCCA-1 measurement in the preoperative diagnosis of IP.…”
Section: Discussionsupporting
confidence: 91%
“…Notably, both SCCA-1 and SCCA-2 mRNA expression values were markedly elevated in IP patients compared with the inflammatory group [16]. Several studies subsequently reported similar results [17][18][19]. However, because all of these studies were retrospective case series with selection bias, we sought to confirm the significance of SCCA values for the preoperative detection of IP in a prospective study.…”
Section: Introductionmentioning
confidence: 93%
“…Because prognosis of IPs is worse than that of NPs, the preoperative differential diagnosis of these two diseases is of great importance for selecting the appropriate surgical methods and the prognosis of patients [ 5 ]. However, NPs and IPs often have similar appearance, and it is difficult to distinguish them in clinical settings [ 6 ].…”
Section: Introductionmentioning
confidence: 99%
“…A literature review identified 30 papers reporting clinical factors potentially associated with the non-cancer specific elevation of serum SCC levels ( Figure S2 , Table 2 ) [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ]. Based on these data, the association between benign respiratory disease, benign skin disease, or renal dysfunction (RD, defined by an estimated glomerular filtration rate of <60 mL/min/1.73 m 2 over 3 months [ 46 ]) during the follow-up and the occurrence of SCC elevation was analyzed.…”
Section: Resultsmentioning
confidence: 99%