Death from large burn wounds has pushed the development of life-saving techniques to cover and heal these wounds as rapidly as possible, resulting in a variety of tissue engineered skin substitutes available on the market. There remains a paucity of good quality RCTs evaluating the efficacy of skin substitutes, and even fewer studies comparing products to each other. While some products have been used successfully for dermatologic applications and published in the literature, a vast majority of data that we do have on skin substitutes relates to chronic wound management and care of burn patients. Though not specific to our specialty, the use of skin substitutes for these indications can be extrapolated to dermatology. Understanding the composition, advantages/disadvantages, and risk/benefit of each product, as well as the indications for each product's use, facilitates the selection of the appropriate substitute. This review will hopefully provide the information that makes the use of these products feasible for the appropriate defect.