The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. The JNC 7 Report

Chobanian, Aram V.; Bakris, George L.; Black, Henry R.; Cushman, William C.; Green, L. A.; Izzo, Joseph L.; Jones, David; Materson, Barry J.; Oparil, S.; Wright, Jackson T.; Toccella, J. R.; Rocella, Edward J.; Brown, Melissa M.

doi:10.1097/00132578-200307000-00027

Cited by 889 publications

(1,340 citation statements)

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“…Recent guidelines for high blood pressure management, stressed the importance of preventive strategies like lifestyle and dietary modifications (Chobanian et al, 2003). In this sense, Miron et al (2004) observed that the drug Captopril demonstrated potent antihypertensive properties due to its ability to inhibit the angiotensin-converting enzyme, whereas allicin decreased serum cholesterol and triglyceride levels.…”

Section: Bioactivity Perspectives and Applications Of Allium Sulfur mentioning

confidence: 99%

Stability and extraction of bioactive sulfur compounds from Allium genus processed by traditional and innovative technologies

Poojary

Putnik

Kovačević

et al. 2017

Journal of Food Composition and Analysis

122

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Section: Bioactivity Perspectives and Applications Of Allium Sulfur mentioning

confidence: 99%

Stability and extraction of bioactive sulfur compounds from Allium genus processed by traditional and innovative technologies

Poojary

Putnik

Kovačević

et al. 2017

Journal of Food Composition and Analysis

122

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“…140 mmHg and/or mean diastolic blood pressure (DBP) ! 90 mmHg (Chobanian et al, 2003) or current anti-hypertensive medication. The exclusion criteria were persons with secondary hypertension (hypertension due to secondary causes such as renovascular disease, renal failure, pheochromocytoma, aldosteronism or other causes of secondary hypertension), diabetes or under lipid-lowering drugs.…”

Section: Patientsmentioning

confidence: 99%

Association of angiotensin-converting enzyme and angiotensin-converting enzyme-2 gene polymorphisms with essential hypertension in the population of Odisha, India

Patnaik

Pati

Swain³

et al. 2013

Annals of Human Biology

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“…183,185 Other drugs may be specifically indicated based on medical circumstances (such as ACE inhibitors in congestive heart failure). 267 It is widely recognized that individual responses to different antihypertensive medications are highly variable. The field of pharmacogenomics promises to provide tools to help identify individuals who may respond better to particular medications, but specific, clinically useful examples are few.…”

Section: Implications For the Management Of Hypertensionmentioning

confidence: 99%

“…Although a few instances of differential response based on genotype are noted above, none are sufficiently consistent to warrant changing recommended treatment approaches that are based on clinical trial data. 267,270 Summarizing the contribution of genetics to current treatment choice for the vast majority of hypertensives, there is no genetic test that contributes in a meaningful way to choice of antihypertensive drugs or diet intervention. This remains true currently despite enticing leads regarding potentially greater salt responsiveness for variants of genes such as ␣-adducin, ENaC, or some of the genes of the RAS.…”

Section: Implications For the Management Of Hypertensionmentioning

confidence: 99%

“…A reduced salt diet and an abundant intake of fruits and vegetables should also be a part of the dietary advice given to persons with a strong family history of hypertension. 267,270 A careful family history frequently discloses familial lipid disorders in hypertensive patients. Familial dyslipidemic hypertension or familial metabolic syndrome with a predominance of moderately increased triglycerides and low HDL is the most common picture.…”

Section: Genetics Of Hypertensionmentioning

confidence: 99%

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Genetics of hypertension

Hopkins

Hunt

2003

Genetics in Medicine

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Hypertension is the most prevalent cardiovascular disorder. In the 1999 to 2000 NHANES survey, the prevalence of hypertension progressively increased from 7.2% in those aged 18 to 39 to 30.1% in 40 to 59 year olds and 65.4% in those 60 and older. 1 Risk of both coronary atherosclerosis and stroke increase exponentially as blood pressure rises (see Fig. 1). 2 Although the relative risk for stroke increases more rapidly than coronary disease, at any pressure, the absolute risk for coronary disease is considerably greater than for stroke. An insight into this finding comes from autopsy studies that show that the carotid and intracerebral vascular beds are relatively protected from atherosclerosis as compared to the coronary circulation, particularly at lower blood pressures (see Fig. 2). 3,4 Probably the major means whereby hypertension accelerates atherosclerosis is through pressure-driven convection of LDL and other atherogenic particles into the arterial intima. 5-8 Indeed, without at least arterial pressures, atherosclerosis does not exist in the vascular tree 9 even in patients with homozygous familial hypercholesterolemia. 10,11 Increased turbulence (a rare occurrence in the human circulatory system) does not increase atherosclerosis. Rather, higher sheer stress is a strong stimulus for release of nitric oxide that locally decreases risk of atherosclerosis. Focal areas of low sheer stress are at inherently increased risk of atherosclerotic disease (such as the coronary arteries where flow stops during each systole). 12 Interestingly, in most studies, stroke risk has been affected little by serum total cholesterol, 13,14 although some recent studies identify clear associated risk. 15 At least some association with all standard cardiovascular risk factors should be expected, not only because thromboembolic stroke may be caused by carotid tree atherosclerosis, but because aortic plaques have been strongly implicated as an embolic source for ischemic stroke. 16 -18 Hypertension is not just a risk factor for atherosclerosis. High blood pressure can have direct adverse effects on arteries, arterioles, and the heart, resulting in potentially severe consequences beyond the more common manifestations of myocardial infarction and atherothrombotic stroke. Even modestly elevated blood pressure is a major risk factor for congestive heart failure. 19,20 Hypertension is a major contributor to left ventricular hypertrophy, a major risk factor for sudden death independent of other risk factors. 21,22 Hypertension can lead progressively to arterial and arteriolar hypertrophy, arteriosclerosis and arteriolosclerosis, and with very high pressures to fibrinoid change and fibrinoid necrosis in arterioles. These latter changes can result in lumen compromise of arterioles resulting in lacunar stroke, Charcot-Bouchard aneurysms, glomerulosclerosis and nephrosclerosis, and ultimately malignant hypertension in the kidney and retinal ischemia and blindness. Risk of intracerebral hemorrhage is increased 33-fold at stage 3 or higher pre...

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The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. The JNC 7 Report

Cited by 889 publications

References 2 publications

Stability and extraction of bioactive sulfur compounds from Allium genus processed by traditional and innovative technologies

Stability and extraction of bioactive sulfur compounds from Allium genus processed by traditional and innovative technologies

Association of angiotensin-converting enzyme and angiotensin-converting enzyme-2 gene polymorphisms with essential hypertension in the population of Odisha, India

Genetics of hypertension

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