The severity of atopic dermatitis and the relation to the level of total IgE, onset of atopic dermatitis and family history about atopy

Vaněčková, J.; Bukač, Josef

doi:10.1080/09540105.2016.1183598

Cited by 16 publications

(17 citation statements)

References 34 publications

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“…We have created a unique group of patients, in which the different parameters concerning atopic march in 172-301 patients were studied. The detailed description of these studies is recorded in our previous publications (Celakovska, Bukac, & Ettler, 2015;Celakovska, Ettlerova, Ettler, Vaněčková, & Bukač, 2015;Celakovska & Bukac, 2015a, 2015b, 2016a, 2016b, 2017a, 2017bČelakovská, Krčmová, Bukač, & Vaněčková, 2017;Vaneckova & Bukac, 2016. All these patients were examined in the Department of Dermatology, Faculty Hospital Hradec Králové, Charles University of Prague, Czech Republic.…”

Section: Methodsmentioning

confidence: 99%

Atopic dermatitis in adolescents and adults – the evaluation of association with other allergic diseases and parameters

Čelakovská

Bukač

Ettlerová

et al. 2017

Food and Agricultural Immunology

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There is a lack of reports focusing on the course of atopic dermatitis (AD) with respect to its evolution and association with other allergic diseases and parameters. This study gives the review of results concerning the evaluation of different parameters in patients suffering from AD older than 14 years of age. This study evaluates the occurrence of food allergy, food intolerance, inhalant allergy, occurrence of asthma bronchiale, allergic rhinitis, peripheral blood eosinophilia, family history of atopy, onset of AD and the severity of AD according to the SCORAD index. ARTICLE HISTORY

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Section: Methodsmentioning

confidence: 99%

Atopic dermatitis in adolescents and adults – the evaluation of association with other allergic diseases and parameters

Čelakovská

Bukač

Ettlerová

et al. 2017

Food and Agricultural Immunology

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“…In our study, essential symptoms such as pruritus, typical morphology and agespecific patterns and chronic or relapsing history accounted for 100%, 92% and 80%, respectively. According to Truong Tieu Vi et al ( 2018) and Tran Gia Hung (2020), the percentage of pruritus was 100% [5], [12]. The other results in the group of essential symptoms also showed similar results.…”

Section: Discussionmentioning

confidence: 71%

“…Besides, in group of important symptoms, xerosis accounted for 82%, personal or family history held 70% and early age of onset made up 18%. According to Vu Thi Minh Nhat (2015), Donald Y.M Leung (2014), Truong Tieu Vi (2018) and Tran Gia Hung (2020), the percentage of xerosis accounted for 100%, 50-70%, 100% and 97.83%, respectively [5], [8], [10], [12]. In addition, in group of associated symptoms, keratosis pilaris/pityriasis alba/hyperlinear palms/ichtyosis accounted for the highest with 72%, followed by perifollicular accentuation/lichenification/prurigo lesions (38%), ocular/periorbital changes (36%), other region findings (18%) and the lowest was atypical vascular responses (12%).…”

Section: Discussionmentioning

confidence: 99%

CLINICAL FEATURES, TOTAL AND SPECIFIC IgE SERUM CONCENTRATIONS OF PATIENTS WITH ATOPIC DERMATITIS AT CAN THO HOSPITAL OF DERMATO-VENEREOLOGY

Nguyen

Tran

Nguyen

et al. 2022

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Background: Atopic dermatitis is a common skin disease in children as well as in adults, with the important feature of being recurrent. Immune disorders (the role of Specific IgE serum) have a relation to the severity of the disease and the risk of allergy in patients. Objectives: 1). To describe the clinical features of patients with atopic dermatitis at Can Tho Hospital of DermatoVenereology in 2021; 2). To determine the total and specific IgE serum concentration in patients with atopic dermatitis at Can Tho Hospital of Dermato-Venereology in 2021. Materials and methods: A cross-sectional descriptive study was carried out on 50 patients with atopic dermatitis hospitalized at Can Tho Hospital of Dermato-Venereology. Results: The rate of itching and types of eczematous lesions accounted for 100%, skin lesions with typical morphology and age-specific patterns were approximately 92%, chronic or relapsing history held 80%, xerosis rate was up to 82%, early age of onset made up 18%, the rate of increase in total and specific IgE serum level in patients with atopic dermatitis was 54% and 84%, respectively, the mean total IgE serum concentration was 210.01 ± 157.88 IU/mL, the lowest was 6.54 IU/mL and the highest was 741.23 IU/mL. D. pteronyssinus and D. farina accounted for the highest proportion of respiratory allergens (46%), cocoa beans accounted for the highest proportion of food allergens (28%). Conclusions: Atopic dermatitis in adult patients associated with pruritus, D. pteronyssinus and D. farina in respiratory allergens and cocoa beans in food allergens was the most common. Total and specific serum IgE concentrations are often elevated in patients with atopic dermatitis.

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“…Most of the patients with AD (80%~90%) have been reported to have high serum immunoglobulin E (IgE) levels 4 . Although the role of IgE in the pathogenesis of AD has not yet been fully understood 1 , it has been reported that serum IgE levels can be used as a parameter of severity for AD 4 .…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Effect of Glucosamine on an Atopic Dermatitis Animal Model

et al. 2019

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Background Recent studies have reported that glucosamine (GlcN) showed therapeutic effects in allergic diseases such as asthma and rhinitis, and its mechanisms include the suppression of T helper type 2 immune responses and the nuclear factor-κB pathway. Objective We aimed to investigate the effect of GlcN on atopic dermatitis (AD) in an animal model. Methods Twenty-five BALB/c mice were divided into five groups (groups A~E). Group A was the phosphate-buffered saline (PBS)-treated group without AD induction. Group B was the PBS control group with AD induction. Groups C to E were the AD induction groups, which were treated with three different doses of GlcN (10 mg, 20 mg, and 40 mg, respectively). Histopathological examination was performed after GlcN administration. Interleukin (IL)-4, IL-13, and IL-17 cytokine levels were measured by enzyme-linked immunosorbent assay using skin biopsy specimens. Serum total immunoglobulin E (IgE) concentrations were measured before and after administration with GlcN or PBS. Results Clinical dermatitis scores decreased with increasing GlcN dose ( p <0.001). Concentrations of tissue IL-13 and IL-17 decreased after GlcN administration (each group: p =0.002 and p <0.001, respectively), but the concentrations of tissue IL-4 did not show differences across groups. Serum IgE levels tended to be lower after GlcN administration ( p =0.004). Histopathological scores were not significantly different among groups B~E ( p =0.394). Conclusion GlcN improved AD symptoms and decreased tissue IL-13, IL-17, and serum total IgE levels in an animal model.

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The severity of atopic dermatitis and the relation to the level of total IgE, onset of atopic dermatitis and family history about atopy

Cited by 16 publications

References 34 publications

Atopic dermatitis in adolescents and adults – the evaluation of association with other allergic diseases and parameters

Atopic dermatitis in adolescents and adults – the evaluation of association with other allergic diseases and parameters

CLINICAL FEATURES, TOTAL AND SPECIFIC IgE SERUM CONCENTRATIONS OF PATIENTS WITH ATOPIC DERMATITIS AT CAN THO HOSPITAL OF DERMATO-VENEREOLOGY

Therapeutic Effect of Glucosamine on an Atopic Dermatitis Animal Model

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