The Shanghai Changfeng Study: a community-based prospective cohort study of chronic diseases among middle-aged and elderly: objectives and design

Gao, Xin; Hofman, Albert; Hu, Yu; Zhu, Chouwen; Jeekel, J.; Jin, Xuejuan; Wang, Jiyao; Gao, Xin; Yin, Yue-Ping; Zhao, Na

doi:10.1007/s10654-010-9525-6

Cited by 61 publications

(56 citation statements)

References 122 publications

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“…Third, the present study was a casecontrolled, hospital-based study. A population-based prospective study in the Chinese population (the Changfeng study) was performed, 31 and the findings in the present study will be confirmed in this population. Lastly, only one SNP was tested in the present study; thus, other functional SNPs and tagging SNPs need to be studied.…”

Section: Discussionsupporting

confidence: 71%

The obesity-related polymorphism PCSK1 rs6235 is associated with essential hypertension in the Han Chinese population

Ling

et al. 2012

Hypertens Res

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Proprotein convertase subtilisin/kexin-type 1 (PCSK1) is a prohormone convertase that has an important role in prohormone maturation including the process of prorenin to renin. We studied the association of the PCSK1 single-nucleotide polymorphism (SNP) rs6235 (encoding an S690T substitution) with essential hypertension (EH), obesity and related traits in the Han Chinese population. The rs6235 SNP in the PCSK1 gene was investigated using a case-control study design, with 1034 hypertension cases and 1112 normotensive controls. In this study, the rs6235 SNP was significantly associated with hypertension (OR ¼ 1.26, 95% CI (1.10-1.46), P ¼ 0.001); the odds ratios of GC vs GG and CC vs GG were 1.30 (95% CI (1.06-1.58), P ¼ 0.010) and 1.55 (95% CI (1.12-2.13), P ¼ 0.007), respectively. In the controls, the C-allele was associated with increased systolic (P ¼ 0.010) and diastolic (P ¼ 0.010) blood pressure levels. In all of the EH patients and EH patients without a history of renin-angiotensin-aldosterone (RAA) system-related antagonists, the C-allele was associated with increased plasma renin activity (P ¼ 0.00004 and 0.002, respectively) and aldosterone levels (P ¼ 0.018 and 0.005, respectively). The C-allele was also associated with increased body mass index (BMI) (P ¼ 0.010) in the normotensive controls. In conclusion, the PCSK1 SNP rs6235 was associated with EH and blood pressure in the Han Chinese population, and this association may be mediated by the SNP's effect on RAA levels. rs6235 was also associated with BMI in this population.

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Section: Discussionsupporting

confidence: 71%

The obesity-related polymorphism PCSK1 rs6235 is associated with essential hypertension in the Han Chinese population

Ling

et al. 2012

Hypertens Res

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“…All the 485 subjects received abdominal computed tomography (CT). To further validate the visceral fat index in Chinese, 6495 subjects (2761 men and 3734 women) were recruited from Changfeng Community, Shanghai31.…”

Section: Methodsmentioning

confidence: 99%

A indicator of visceral adipose dysfunction to evaluate metabolic health in adult Chinese

Xia

Chen

Hao

et al. 2016

Sci Rep

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Visceral adipose dysfunction is a major cause of metabolic disorders. However, there is lack of a clinical index for prediction of visceral fat dysfunction in Asians. The present study aims to establish a visceral adiposity index for evaluation of metabolic health status in Chinese, the largest Asian ethnic group. 485 subjects were recruited from Lianqian Community, Xiamen and received abdominal computed tomography(CT) for visceral fat area. A Chinese visceral adiposity index (CVAI) was created using multivariate linear regression analyses, and was further validated in 6495 subjects recruited from Changfeng Community, Shanghai. CVAI was well associated with visceral obesity (r = 0.68, P < 0.001) and HOMA-IR (r = 0.60, P < 0.001). The AUROCs were 0.89(0.88–0.90), 0.72(0.71–0.73), 0.69(0.68–0.71) and 0.67(0.65–0.68) for determination of metabolic syndrome, hypertension, diabetes and prediabetes, respectively. CVAI was more valuable compared to BMI and waist circumference in evaluation of metabolic risks (all P < 0.001), even in subjects with metabolically unhealthy normal weight (MUNW) and metabolically healthy obese/overweight (MHO). This study demonstrates that CVAI is a reliable and applicable index for evaluation of visceral fat dysfunction in Chinese. It might be used to evaluate metabolic health status in Asians.

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“…A total of 4576 middle-aged and elderly Chinese community subjects were consecutively enrolled from May 2010 to June 2012 [15], and 1028 participants were excluded due to known viral hepatitis B (n = 163), viral hepatitis C (n = 3), excessive alcohol consumption (≥140g per week for men and ≥70g per week for women) [16] (n = 627) and use of hypoglycemic drugs or insulin (n = 235). This left 3548 subjects (1249 males and 2299 females) to be included in the final analysis.…”

Section: Methodsmentioning

confidence: 99%

Influence of Ethnicity on the Accuracy of Non-Invasive Scores Predicting Non-Alcoholic Fatty Liver Disease

et al. 2016

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ObjectivesPresence of non-alcoholic fatty liver disease (NAFLD) can predict risks for diabetes, cardiovascular disease and advanced liver disease in the general population. We aimed to establish a non-invasive score for prediction of NAFLD in Han Chinese, the largest ethnic group in the world, and detect whether ethnicity influences the accuracy of such a score.MethodsLiver fat content (LFAT) was measured by quantitative ultrasound in 3548 subjects in the Shanghai Changfeng Community and a Chinese score was created using multivariate logistic regression analyses. This new score was internally validated in Chinese and externally in Finns. Its diagnostic performance was compared to the NAFLD liver fat score, fatty liver index (FLI) and hepatic steatosis index (HSI) developed in Finns, Italians and Koreans. We also analyzed how obesity related to LFAT measured by 1H-MRS in 79 Finns and 118 Chinese with type 2 diabetes (T2D).ResultsThe metabolic syndrome and T2D, fasting serum insulin, body mass index (BMI) and AST/ALT ratio were independent predictors of NAFLD in Chinese. The AUROC in the Chinese validation cohort was 0.76 (0.73–0.78) and in Finns 0.73 (0.68–0.78) (p<0.0001). 43%, 27%, 32% and 42% of Chinese had NAFLD when determined by the Chinese score, NAFLD liver fat score (p<0.001 vs. Chinese score), FLI (p<0.001) and HSI (NS). For any given BMI and waist circumference, the Chinese had a markedly higher LFAT than the Finns.ConclusionThe predictors of NAFLD in Han Chinese are as in Europids but the Chinese have more LFAT for any given degree of obesity than Europids. Ethnicity needs to be considered when NAFLD is predicted using risk scores.

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The Shanghai Changfeng Study: a community-based prospective cohort study of chronic diseases among middle-aged and elderly: objectives and design

Cited by 61 publications

References 122 publications

The obesity-related polymorphism PCSK1 rs6235 is associated with essential hypertension in the Han Chinese population

The obesity-related polymorphism PCSK1 rs6235 is associated with essential hypertension in the Han Chinese population

A indicator of visceral adipose dysfunction to evaluate metabolic health in adult Chinese

Influence of Ethnicity on the Accuracy of Non-Invasive Scores Predicting Non-Alcoholic Fatty Liver Disease

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