The short-term improvements of enriched environment in behaviors and pathological changes of APP/PS1 mice via regulating cytokines

Zhang, Yuwei; Wang, Ge; Wang, Lin; Zhao, Jingping; Huang, Rui; Xiong, Qian-Ying

doi:10.1080/21645515.2018.1463944

Cited by 8 publications

(7 citation statements)

References 26 publications

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“…Decreased levels of pro-inflammatory molecules in serum was previously described in a model of Alzheimer disease. This model demonstrated an improved cognitive performance in EE animals (Zhang et al, 2018). EE helped to ameliorate the negative cognitive effects of peripheral infection (Jurgens and Johnson, 2012).…”

Section: Discussionmentioning

confidence: 87%

Environmental enrichment improves cognitive symptoms and pathological features in a focal model of cortical damage of multiple sclerosis

et al. 2020

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Discussionmentioning

confidence: 87%

Environmental enrichment improves cognitive symptoms and pathological features in a focal model of cortical damage of multiple sclerosis

et al. 2020

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“…The present study found no significant differences between groups in terms of the percentage of spontaneous alternation and the total number of arm entries, indicating that APP and PS1 mutations did not affect working memory and locomotion in this test. Earlier research has reported mixed results in these tasks in APP/PS1 mice [28][29][30][31][32][33][34][35]. However, it is currently unclear what contributes to the discrepancies.…”

Section: Discussionmentioning

confidence: 95%

Partial Endothelial Nitric Oxide Synthase Deficiency Exacerbates Cognitive Deficit and Amyloid Pathology in the APPswe/PS1ΔE9 Mouse Model of Alzheimer’s Disease

Ahmed

Mockett

et al. 2022

IJMS

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Increasing evidence implicates endothelial dysfunction in the pathogenesis of Alzheimer’s disease (AD). Nitric oxide (NO) derived from endothelial NO synthase (eNOS) is essential in maintaining cerebrovascular function and can modulate the production and clearance of amyloid beta (Aβ). APPswe/PSdE1 (APP/PS1) mice display age-related Aβ accumulation and memory deficits. In order to make the model more clinically relevant with an element of endothelial dysfunction, we generated APP/PS1/eNOS+/− mice by crossing complete eNOS deficient (eNOS−/−) mice and APP/PS1 mice. APP/PS1/eNOS+/− mice at 8 months of age displayed a more severe spatial working memory deficit relative to age-matched APP/PS1 mice. Moreover, immunohistochemistry and immunoblotting revealed significantly increased Aβ plaque load in the brains of APP/PS1/eNOS+/− mice, concomitant with upregulated BACE-1 (hence increased Aβ production), downregulated insulin-degrading enzyme (hence reduced Aβ clearance) and increased immunoreactivity and expression of microglia. The present study, for the first time, demonstrated that partial eNOS deficiency exacerbated behavioral dysfunction, Aβ brain deposition, and microglial pathology in APP/PS1 mice, further implicating endothelial dysfunction in the pathogenesis of AD. The present findings also provide the scientific basis for developing preventive and/or therapeutic strategies by targeting endothelial dysfunction.

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“…Among the beneficial effects of EE that could account for the protective effect on the increased ethanol intake and the neuroinflammatory response, we should highlight an increase in neurogenesis with an elevated expression of brain-derived neurotrophic factor (BDNF; Novkovic et al, 2015 ; Schloesser et al, 2010 ) and an enhanced synaptic and transcriptomic capacity ( Hüttenrauch et al, 2016 ; Zhang et al, 2018 ). Exposure to EE during adolescence could also change the dynamics of social interaction, sensory processing and the mechanisms underlying baseline stress, with a decrease in CRHR1 genes and an increase in hippocampal CRHR2 observed in male rats housed in EE conditions ( Kentner et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Ethanol intake in male mice exposed to social defeat: Environmental enrichment potentiates resilience

Reguilón

Ferrer-Pérez

Manzanedo

et al. 2021

Neurobiology of Stress

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The short-term improvements of enriched environment in behaviors and pathological changes of APP/PS1 mice via regulating cytokines

Abstract: The EE can improve the behaviors of AD mice, reduce the Aβ deposition in the brain, regulate the levels of cytokines, and have benefit in pathological changes in AD, but these improvements are short-term.

Cited by 8 publications

References 26 publications

Environmental enrichment improves cognitive symptoms and pathological features in a focal model of cortical damage of multiple sclerosis

Environmental enrichment improves cognitive symptoms and pathological features in a focal model of cortical damage of multiple sclerosis

Partial Endothelial Nitric Oxide Synthase Deficiency Exacerbates Cognitive Deficit and Amyloid Pathology in the APPswe/PS1ΔE9 Mouse Model of Alzheimer’s Disease

Ethanol intake in male mice exposed to social defeat: Environmental enrichment potentiates resilience

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