The Sialyl Lewis X Analogue, CY-1503, Down-regulates Leucocyte-Endothelium Interactions and the Inflammatory Response

García-Criado, Francisco Javier; Valdunciel-Garcia, J. J.; Garcia‐Garcia, Jacinto; Ramos-Boyero, Manuel; Sanchez‐Fernandez, Jose; Zambrano‐Cuadrado, Yolanda; Gonzalo‐Iglesias, Maria D.; Lozano-Sanchez, Francisco; Gómez‐Alonso, Alberto

doi:10.1080/11024159950189762

The European Journal of Surgery

1999

DOI: 10.1080/11024159950189762

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The Sialyl Lewis X Analogue, CY-1503, Down-regulates Leucocyte-Endothelium Interactions and the Inflammatory Response

Francisco Javier García-Criado

J. J. Valdunciel-Garcia²,

Jacinto Garcia‐Garcia³

et al.

Abstract: CY-1503 exerts a protective effect in that it able to down-regulate concentrations of free radicals in our rat model. It is a potent inhibitor of neutrophil migration, but has no effect on cytokine concentrations.

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P- and E-Selectin Blockade Can Control Bacterial Translocation and Modulate Systemic Inflammatory Response

García-Criado¹,

Lozano²,

Barros³

et al. 2005

Journal of Investigative Surgery

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Bacterial translocation is an important phenomenon in clinical medicine and leads to an increase in patient morbidity and mortality by multiple organ failure. The selectin family plays an important role in the pathogenesis of inflammation, causing an increase in leukocyte-endothelium interactions and inducing a greater leukocyte's migration. This study considered the effect of a sulfo derivative of Sialyl-Lewis(X), GM 1998-016, that will block the P- and E-selectins interaction with a ligand, the Sialyl-Lewis(X), valuing the modulation of the systemic inflammatory response and the induced translocation. Seventy-five Wistar male rats were injected intraperitoneally with Zymosan A and treated with different doses of GM 1998-016 according to study groups. Measurements of values of qualitative and quantitative microbiology, neutrophil infiltration (myeloperoxidase), oxygen free radicals (superoxide anion, superoxide dismutase, catalase, and gluthatione peroxidase), and cytokines (tumor necrosis factor-alpha and interleukin-1beta) were taken at different times after Zymosan administration. A significant decrease of bacterial translocation, both local (MLN) and systemic (p < .05), was observed, with a decrease in the neutrophil infiltration (p < .001), the oxygen free radicals production (p < .01) and the studied cytokines (p < .01). In conclusion, GM 1998-016 showed a protective effect in an in vivo experimental model of bacterial translocation, downregulating the inflammatory response and the leukocyte-endothelium interactions.

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P- and E-Selectin Blockade Can Control Bacterial Translocation and Modulate Systemic Inflammatory Response

García-Criado¹,

Lozano²,

Barros³

et al. 2005

Journal of Investigative Surgery

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show abstract

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The Sialyl Lewis X Analogue, CY-1503, Down-regulates Leucocyte-Endothelium Interactions and the Inflammatory Response

Abstract: CY-1503 exerts a protective effect in that it able to down-regulate concentrations of free radicals in our rat model. It is a potent inhibitor of neutrophil migration, but has no effect on cytokine concentrations.

Cited by 1 publication

References 0 publications

P- and E-Selectin Blockade Can Control Bacterial Translocation and Modulate Systemic Inflammatory Response

P- and E-Selectin Blockade Can Control Bacterial Translocation and Modulate Systemic Inflammatory Response

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