2015
DOI: 10.18632/oncotarget.3003
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The significance of PIWI family expression in human lung embryogenesis and non-small cell lung cancer

Abstract: The expression of Piwi-interacting RNAs, small RNAs that bind to PIWI proteins, was until recently believed to be limited to germinal stem cells. We have studied the expression of PIWI genes during human lung embryogenesis and in paired tumor and normal tissue prospectively collected from 71 resected non-small-cell lung cancer patients. The mRNA expression analysis showed that PIWIL1 was highly expressed in 7-week embryos and downregulated during the subsequent weeks of development. PIWIL1 was expressed in 11 … Show more

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Cited by 46 publications
(45 citation statements)
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“…Previous studies have suggested that PIWIL1 could endow cancer cells with stem-like properties to acquire a proliferative or metastatic potential during tumor initiation and progression [16,32]. In this study, functional annotation of coexpressed genes based on TCGA lung adenocarcinoma data also indicated that overexpression of PIWIL1 was associated with embryonic development, cell proliferation, and regulation of transcription.…”
Section: Discussionsupporting
confidence: 56%
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“…Previous studies have suggested that PIWIL1 could endow cancer cells with stem-like properties to acquire a proliferative or metastatic potential during tumor initiation and progression [16,32]. In this study, functional annotation of coexpressed genes based on TCGA lung adenocarcinoma data also indicated that overexpression of PIWIL1 was associated with embryonic development, cell proliferation, and regulation of transcription.…”
Section: Discussionsupporting
confidence: 56%
“…observed that Hiwi knockdown could inhibit the growth of lung cancer in nude mice . Taken together, these evidences suggested that the activation of PIWIL1 might be necessary for the tumorigenesis of lung adenocarcinoma.Previous studies have suggested that PIWIL1 could endow cancer cells with stem‐like properties to acquire a proliferative or metastatic potential during tumor initiation and progression . In this study, functional annotation of coexpressed genes based on TCGA lung adenocarcinoma data also indicated that overexpression of PIWIL1 was associated with embryonic development, cell proliferation, and regulation of transcription.…”
Section: Discussionsupporting
confidence: 55%
See 1 more Smart Citation
“…Moreover, Piwil2 expression was not exclusive to HRS cells but was also detected in most of the microenvironment cells, indicating that the secondary pathway is not exclusive to tumor cells. Along these same lines, PIWIL2 and PIWIL4 have been detected in other tumors as well in their normal counterpart [36, 41]. …”
Section: Discussionmentioning
confidence: 77%
“…The primary pathway is in charge of generating new piRNA sequences, while the secondary pathway helps to maintain the existent piRNA pool in the cell [35]. Interestingly, in several solid tumors, the reactivation of PIWIL1 expression, associated with worse prognosis, could be related to a stem cell phenotype [3639]. Similarly, PIWIL1 is expressed in CD34+ hematopoietic stem cells [40].…”
Section: Discussionmentioning
confidence: 99%