The significance of macrophage phenotype in cancer and biomaterials

Bygd, Hannah C.; Forsmark, Kiva D.; Bratlie, Kaitlin M.

doi:10.1186/s40169-014-0041-2

Cited by 27 publications

(40 citation statements)

References 145 publications

(293 reference statements)

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“…M1 macrophages were suggested to be associated with better prognosis of patients with NSCLC and act as efficient immune cells with antitumor capacities [4]. M2 with the most prevalent phenotype might promote tumor growth, angiogenesis, invasion, and metastasis through the suppression of the adaptive immunity by inducing T cell dysfunction [4,20].…”

Section: Roles Of Inflammatory Cells In Cancer-related Inflammationmentioning

confidence: 99%

Targeting roles of inflammatory microenvironment in lung cancer and metastasis

Shi

Wang

Hou

et al. 2015

Cancer Metastasis Rev

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Inflammatory cells and mediators are essential components in tumor microenvironment and play decisive roles in the initiation, proliferation, survival, promotion, invasion, or metastasis of lung cancer. Clinical and epidemiologic studies suggested a strong association between inflammation and lung cancer and an influence of immune surveillances and tumor responses to chemotherapeutic drugs, although roles of inflammation in lung cancer remain unclear. The present review outlined roles of inflammation in lung cancer, with particular focus on inflammatory components, types, biomarkers, or principal mechanisms by which the inflammation contributes to the development of lung cancer. The cancer-associated inflammatory cells (CICs) should be furthermore defined and include cancer-specific and interacted cells with inflammatory or inflammation-like characteristics, e.g., innate or adaptive immune cells and cancer tissue cells. We also discuss targeting potentials of inflammation in the prevention and treatment of lung cancer. The diversity of cancer-related inflammatory microenvironment is instrumental to design novel therapeutic approaches for lung cancer.

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Section: Roles Of Inflammatory Cells In Cancer-related Inflammationmentioning

confidence: 99%

Targeting roles of inflammatory microenvironment in lung cancer and metastasis

Shi

Wang

Hou

et al. 2015

Cancer Metastasis Rev

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“…83 However, the innate and complex intricacies in biological responses to material properties are challenging to predict a priori, meaning that implant failure often occurs as a result of inflammation 84 and fibrous encapsulation. 85 Abating or eliminating such host responses is of central importance in current bio-implant design. There are several key characteristics involved in the host response to biomaterials, two of which are activation of macrophages and fibroblasts.…”

Section: Introductionmentioning

confidence: 99%

pH responsive gels that deliver anti-inflammatory drugs

Zhu

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Herein, we give a brief overview on how changes in macrophages and fibroblasts phenotypes are critical biomarkers for identification of implant acceptance, wound healing effectiveness, and are also essential for evaluating the regenerative capabilities of some hybrid strategies that involve the combination of natural and synthetic materials. The different types of cells present during the host response have been extensively studied for evaluating the reaction to different materials and there are varied material approaches towards fabrication of biocompatible substrates. Several fabrication strategies are discussed to control the phenotype of infiltrating macrophages and fibroblasts. It is essential to factor all the different design principles and material fabrication criteria for evaluating the choice of implant materials or regenerative therapeutic strategies.

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“…Macrophages act as a principal mediator of inflammatory responses to either injury or implantation, and play a key role in the immune system due to their plasticity and heterogeneous phenotypes. [21][22][23] Macrophages are thought to exist on a spectrum of phenotypes. At one extreme side of the spectrum is termed classically activated M1 macrophages and is achieved through exposure to lipopolysaccharide (LPS) or interferon (IFN)-γ. Macrophages activated through the M1 pathway differentiate into a pro-inflammatory phenotype.…”

Section: Introductionmentioning

confidence: 99%

How Cross-Linking Mechanisms of Methacrylated Gellan Gum Hydrogels Alter Macrophage Phenotype

Bratlie

2018

ACS Appl. Bio Mater.

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In tissue engineering scaffolds, macrophages play a critical role in determining the host response to implanted biomaterials. Macrophage phenotype is dynamic throughout the host response, and a balance of phenotypes is essential for timely progression from injury to proper wound healing. Therefore, it is important to predict how materials will modulate the response of macrophages. In this study, we investigated the effect of methacrylated gellan gum hydrogels on macrophage phenotype and proliferation with the ultimate goal of improving rational design of biomedical implants. Naïve, along with classically and alternatively activated RAW 264.7 macrophages were seeded on methacrylated gellan gum hydrogels that were fabricated with different thiol-ene ratios and crosslinking mechanisms. Live/dead assays showed that all hydrogels supported cell attachment and proliferation. Stiffer substrates enhanced anti-inflammatory production of nitrites from both naïve and classically activated macrophages compared to the softer substrates. Moreover, arginine and CD206 expression-markers for alternatively activated macrophages-were inhibited by higher thiol content. Introducing ionic crosslinks using calcium did not influence the proliferation or polarization for any of the three macrophage phenotypes. Our results suggest that the macrophage phenotype shift from M1 to M2 is controlled by the different crosslinking mechanisms, physical properties, and the chemistry of methacrylated gellan gum hydrogels. Disciplines Biochemical and Biomolecular Engineering | Biology and Biomimetic Materials | Biomaterials Comments

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The significance of macrophage phenotype in cancer and biomaterials

Cited by 27 publications

References 145 publications

Targeting roles of inflammatory microenvironment in lung cancer and metastasis

Targeting roles of inflammatory microenvironment in lung cancer and metastasis

pH responsive gels that deliver anti-inflammatory drugs

How Cross-Linking Mechanisms of Methacrylated Gellan Gum Hydrogels Alter Macrophage Phenotype

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