The significance of pigment epithelial detachment in central serous chorioretinopathy

Abstract

Purpose: To investigate the significance of the presence and form of pigment epithelial detachment in the course of central serous chorioretinopathy as well as corticosteroid use as a risk in our patient cohort. Material and methods: Retrospective, single center study of central serous chorioretinopathy patients between January 2013 and January 2019 recording corticosteroid use prior to onset and presence and type of pigment epithelial detachment (flat-irregular, dome-shaped, none) in relationship to disease course. Results: We analyzed 53 eyes of 53 consecutive central serous chorioretinopathy patients treated in our department. Mean patient age was 53 ± 13 years. A flat-irregular pigment epithelial detachment was associated with either chronic or recurrent central serous chorioretinopathy, whereas the absence of a pigment epithelial detachment correlated positively with acute central serous chorioretinopathy (chi-square test, p < 0.05). Of the 53 patients, 10 reported corticosteroid use, 40 denied steroid use, and 3 patients failed to make a clear statement. Corticosteroid use was not correlated with the onset of central serous chorioretinopathy (Student’s t-test, p = 0.0001, chi-square test, p < 0.005). Conclusion: A small, flat-irregular pigment epithelial detachment could be a marker for chronic or recurrent central serous chorioretinopathy, whereas the absence of pigment epithelial detachment could favor acute central serous chorioretinopathy. Advanced imaging studies may provide more information on the exact characteristics and nature of pigment epithelial detachments. Corticosteroid use as possible disease trigger was not confirmed in this study.

Predicting persistent central serous chorioretinopathy using multiple optical coherence tomographic images by deep learning

“…In addition, shallow irregular PED areas were highlighted on the heatmaps. A small, flat, irregular PED could be a marker of chronic or recurrent CSC and implies genetic overlap of patients with AMD, which can explain the refractoriness of the condition 26 , 27 .…”

Correlative study on retinal microvascular changes and sex hormones in male patients with central serous chorioretinopathy

“…As clinical research advances, our understanding of CSC has developed from the RPE level to the choroidal level. It is now generally accepted that the pathogenesis of CSC is associated with choroidal vascular hyperpermeability, RPE barrier disruption, and choroidal dysfunction [15,16]. In FFA examinations, we observed RPE barrier disruption and fluorescein leakage.…”

Time-dependent recurrence and resolution of pigment epithelial detachment in central serous chorioretinopathy

“…CSC after the use of exogenous glucocorticoids has been widely reported in the literature, including oral, inhaled, intranasal, intravenous, intramuscular, intraarticular, and periocular administrations, etc. [ 2 , 5 , 12 – 15 ]. Prakash et al have reported a case where a 35-year-old male experienced four recurrent episodes of CSC within one year, a few days before each episode he was using dexamethasone eye drops intranasally for rhinitis [ 14 ].…”