The significance of (platelet/white blood cell) counts ratio in screening for high risk for preeclampsia and its related complications

Akram, Wisam; Muaeed, Duha

doi:10.4103/mj.mj_35_18

Cited by 2 publications

(4 citation statements)

References 2 publications

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“…A previous study found that the platelet-white blood cell ratio is lower in preeclampsia with and without IUGR than in normotensive pregnancy at 34 weeks. 12 This is related to the low amount of thrombocytes and high leukocytes in severe preeclampsia obtained in this research.…”

Section: Original Articlesupporting

confidence: 52%

“…11 Other research reported the potential of PWR as an additional test for preeclampsia screening and adjuvant fetal health test during antepartum due to its simplicity and convenience. 12 Therefore, this study's objective was to confirm the difference between PWR in preeclampsia and normotensive birth, especially among Indonesian pregnant women.…”

Section: Introductionmentioning

confidence: 98%

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The difference of platelet-white blood cell ratio in severe preeclampsia and normotensive pregnancy

et al. 2022

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Background: Inflammation is believed to play a role in preeclampsia. Leukocytes increase due to inflammatory response. Endothelial damage in preeclampsia induces platelet aggregation, triggers platelet consumption, and decreases platelet. Therefore, preeclampsia could alter the platelet-white blood cell ratio, which can be used as a marker for preeclampsia. This study examines the difference of platelet-white blood cell ratio in severe preeclampsia and normotensive pregnancy. Methods: This study used the medical records of pregnant women in Dr. Kariadi General Hospital Semarang from 2019 to 2020. Samples were collected using a consecutive sampling method. Data were analyzed using an independent t-test and Mann-Whitney. Results: There was a significant difference in platelet count (p=0.011) and leukocyte count (p=0.018) between severe preeclampsia and normotensive pregnancy. Therefore, a difference (p<0.01) in platelet-white blood cell ratio between severe preeclampsia and normotensive pregnancy was observed. Conclusion: Platelet-white blood cell ratio in severe preeclampsia is 0.7 times lower than in normotensive pregnancy.

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Section: Original Articlesupporting

confidence: 52%

Section: Introductionmentioning

confidence: 98%

The difference of platelet-white blood cell ratio in severe preeclampsia and normotensive pregnancy

et al. 2022

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“…74 ± 0.07 pg/ml, p=0.01) was higher in the pre-eclamptic women. Akram et al [20] reported serum free testosterone was significantly higher among women with preeclampsia compared with control 5.00±0.72 versus 1.28±0.97, p<0.001. In addition, some other studies have shown that hypertension is associated with high levels of androgen in non-pregnant healthy women [24,25,26] .…”

Section: Discussionmentioning

confidence: 92%

“…In present study showed that significant strong positive correlation of serum free testosterone with SBP (r=+.731, p<0.001), DBP (r=+.655, p<0.001), proteinuria (r=+.731, p<0.001). Akram et al [20] reported strong positive correlation between serum free testosterone with systolic (r=+.887, p<0.001) and diastolic blood pressure (r=+.892, p<0.001) and protein over creatine ratio (r=+.863, p<0.001).…”

Section: Discussionmentioning

confidence: 98%

Association of serum free testosterone with preeclampsia

Siddika,

Akthar,

Urmee

et al. 2024

Int. J. Clin. Obstet. Gynaecol.

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Background: Preeclampsia is a pregnancy specific disorder characterized by hypertension and proteinuria or new onset of hypertension and significant end organ disfunction with or without proteinuria after 20 weeks of gestation. Preeclampsia is associated with reduction of utero-placental blood flow, which is reflected in high blood pressure and proteinuria during the second half of pregnancy. Hyper-androgenism may be implicated in the pathogenesis of preeclampsia, if so, there should be a difference between the levels of testosterone in pregnant women complicated with preeclampsia and those without this complication.Objective: To determine association of serum free testosterone with preeclampsia. Methods: This case control study was conducted in the department of Obstetrics & Gynaecology of Institute of Child & Mother Health (ICMH), Matuail, Dhaka during September 2021 to August 2022. Patient complicated by preeclampsia and patient without preeclampsia attending Obstetrics and Gynecology Department was included in this study by consecutive sampling. All of them were briefed regarding the study. After that they were included by eligibility criteria and patients were classified into two groups. A total of 80 participants during second half of pregnancy were enrolled and among them 40 patient complicated by preeclampsia was considered as case and 40 patients without preeclampsia was considered as control. A written consent was obtained. Data were analysed by using Statistical Packages for Social Sciences (SPSS-26). The significance test was done by unpaired t test and Chi square test. P value less than 0.05 was considered statistically significant. Results: The mean age of the cases was 23.6±3.66 years and the mean age of the control was 24.25±4.91 years. In both group maximum study subjects were secondary education 40% and 45% in case and control group respectively. Maximum patients 52.5% and 42.5% were 31-35 gestational weeks in case and control group respectively. The mean gestational age 32.1±2.92 weeks in preeclamptic group and 32.4±3.53 weeks in control group. Data analysis revealed no statistically significant difference between two groups patients in terms of sociodemographic parameters (p>0.05). The mean free serum testosterone was 2.91±0.62 in preeclampsia group and 1.19±0.49 in healthy normal pregnancy group. Analysis revealed that mean free serum testosterone was significantly increased among the preeclampsia group than the healthy normal pregnancy group (p<0.001). It was confirmed that the serum free testosterone levels were considerably high in the preeclamptic participants than the participants without preeclampsia. Conclusion:The levels of free testosterone is higher in patients with preeclampsia compared to normotensive pregnant women during the second half of pregnancy. This difference could indicate an involvement of testosterone in the pathophysiology of preeclampsia and stimulates research in the potential role of anti-androgens in the management of preeclampsia.

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The significance of (platelet/white blood cell) counts ratio in screening for high risk for preeclampsia and its related complications

Cited by 2 publications

References 2 publications

The difference of platelet-white blood cell ratio in severe preeclampsia and normotensive pregnancy

The difference of platelet-white blood cell ratio in severe preeclampsia and normotensive pregnancy

Association of serum free testosterone with preeclampsia

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