1975
DOI: 10.1016/s0305-7372(75)80015-6
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The significance of the circulating cancer cell

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Cited by 182 publications
(62 citation statements)
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“…While the conventional conclusion elucidated from the numerous clinical studies has been that mere existence of tumour cells in the blood circulation is not indicative of poor prognosis or inevitable metastasis development (Salsbury, 1975), the present results indicate that number of "clonogenic" tumour-cells released from the primary into the blood or clonogenic tumour-cell release rate may explain both the difference of SLME between FSA1231 and FSA1233 and the discrepancy in artificial and spontaneous metastasis efficiency of these two cell clones.…”
Section: Testfor Variant Selectioncontrasting
confidence: 63%
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“…While the conventional conclusion elucidated from the numerous clinical studies has been that mere existence of tumour cells in the blood circulation is not indicative of poor prognosis or inevitable metastasis development (Salsbury, 1975), the present results indicate that number of "clonogenic" tumour-cells released from the primary into the blood or clonogenic tumour-cell release rate may explain both the difference of SLME between FSA1231 and FSA1233 and the discrepancy in artificial and spontaneous metastasis efficiency of these two cell clones.…”
Section: Testfor Variant Selectioncontrasting
confidence: 63%
“…The possibility of promoting metastasis during diagnostic and therapeutic procedures by inducing TCR from the primary has been suspected (Kaplan & Murphy, 1949;Sheldon & Fowler, 1973;Peters 1975;Baker et al, 1981), though numerous studies of over 20 years on patients' blood failed to establish a positive correlation between the presence of tumour cells in the blood and prognosis (Goldblatt & Nadel, 1965;Salsbury, 1975). Interpretation of data regarding tumour cells in patients' blood is very difficult since most studies used cytological microscopic identification of fixed cells isolated from very small amounts of blood (5-10ml) (Salsbury, 1975) relative to the total human blood volume. Furthermore, in most studies, the source of the blood samples was irrelevant to tumour sites, and clonogenicity and tumorigenicity of these cells were not evaluated.…”
Section: Testfor Variant Selectionmentioning
confidence: 99%
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“…Trauma to tumours increases both cell shedding and metastasis in animal models (Tyzzer, 1913;Liotta et al, 1976), leading to concern that cancer surgery might have similar effects in humans. Early studies of cell shedding in humans were confounded by major sampling and cell identification errors, and a general appreciation of the inadequacy of contemporary techniques led to a decline in interest in the subject (Salsbury, 1975). In recent years emphasis in metastasis research has shifted to the phenotype of the cancer cell, and a number of enzymatic and adhesion molecules have been implicated in the metastatic process (Fidler, 1991;Hart and Saini, 1992).…”
mentioning
confidence: 99%