The simultaneous determination of lidocaine and procainamide in serum by use of high pressure liquid chromatography

Hollow fiber liquid based microextraction combined with high-performance liquid-chromatography for the analysis of lidocaine in biological and pharmaceutical samples

“…Therefore, it is necessary to develop a simple and sensitive analytical technique for determining lidocaine. Several instrumental techniques have been applied for determining lidocaine, which include TLC, 17 HPLC, [18][19][20][21][22][23][24][25][26] GC, 27,28 ion-selective electrode 29 and spectroscopy. 30,31 In spite of developments in modern analytical instruments, extraction and preconcentration are needed for the determination of lidocaine.…”

Displacement of lidocaine from the lung after bolus injection of bupivacaine

“…Lidocaine blood concentration was determined by high-performance liquid chromatography based on the method of Adams et al 7 A Model ALC/GPC 204 Highperformance Liquid Chromatograph equipped with a Model 441 fixed-wavelength absorbance detector (214 nm) and Is Bondapak Ci8 reversed-phase column (all from Waters, Milford, U.S.A.) was used. Five hundred microlitres of each diluted blood sample was placed in a screw-cap centrifuge tube, followed by the addition of 40 ~tl of internal standard solution (procaine 5 rtg" ml-i), 100 ~tl, 1 N NaOH and 5 ml, diethylether.…”

Development of a high-throughput method for the determination of ethosuximide in human plasma by liquid chromatography mass spectrometry

“…There are numerous published procedures that describe the quantitation of ethosuximide in plasma or serum. Different analytical methods for determination of ethosuximide as anticonvulsant drug have been reported, including high performance liquid chromatography (HPLC) [5][6][7][8][9][10][11][12][13], HPLC by derivatization [14,15] and gas chromatographic (GC) by chiral method [16,17]. To date only one LC/API-MS procedure has been reported for the quantitation of ethosuximide [18].…”