The site of analgesic action of non-acidic non-steroidal anti-inflammatory drugs

Nakamura, Hideo; Imazu, Chieko; Shimoda, Atsuko; Motoyoshi, Satoru; Kadokawa, Toshiaki; Shimizu, Masanao

doi:10.2492/jsir1981.4.4_545

Cited by 24 publications

(24 citation statements)

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“…The potency ratio of intracisternal administration to intravenous administration in mouse acetic acid-induced writhing was 7, which was close to that of aminopyrine (5.8) and probably closer to that of morphine (>10) (33). It was concluded that the anti-writhing action of mepirizole and other non-acidic NSAIDs was at least partially mediated via the central nervous system (33).…”

Section: Discussionmentioning

confidence: 88%

A Novel Model of Pain Sensation Using Superfused Gastrosplenic Omentum Preparation of Anesthetized Rats

2008

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Abstract. A pain model for screening analgesics was established in anesthetized rats. The omenta of urethane-anesthetized rats were exteriorized, fixed in a plastic chamber, and superfused with Tyrode solution. Administration of bradykinin (BK) in the chamber elicited the reflex hypertensive response (RHR). Modification of the RHR was tested by topical (in the chamber) or intravenous administration of drugs. The BK dose-response curve was shifted to the right by topical indomethacin. The RHR by BK was inhibited by topical application of a BK B 2 antagonist, (Thi 5,8 -D-Phe 7 -BK), a local anesthetic (2% carbocaine), and by intravenous administration of a ganglion blocker (hexamethonium) or an α-adrenergic blocker (dibenamine). The RHR by topical BK was almost completely inhibited by morphine and the suppression was largely reversed by naloxone. The RHR, induced by a threshold dose of BK and inhibited by indomethacin, was potentiated by pretreatment of the omentum with prostaglandin (PG) E 2 or PGI 2 . PGE 2 was less potent, but the effect lasted longer than that of PGI 2 . Topical administration of a non-acidic analgesic, mepirizole, inhibited the RHR by topical BK by only 20%, but intravenous mepirizole inhibited topical BK by 96.2%, indicating its major central action. This model may be useful for studying analgesics.

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Section: Discussionmentioning

confidence: 88%

A Novel Model of Pain Sensation Using Superfused Gastrosplenic Omentum Preparation of Anesthetized Rats

2008

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“…An increase in the reaction time is generally considered to be an important parameter for evaluating central antinociceptive activity as reported previously [25] . The finding of the flick of the tail could be due to a reflex arc in the spinal cord which was modulated through a descending pathway mechanism [26] . The observed antinociceptive effect of THME (300 and 500 mg/kg, p.o.)…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive Activity of Methanol Extract of Tabebuia hypoleuca (C. Wright ex Sauvalle) Urb. Stems

Regalado

Mancebo

Paixão³

et al. 2017

Med Princ Pract

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than in the control group. In the formalin test, the licking time for THME at doses of 300 and 500 mg/kg was significantly shorter ( p < 0.001) compared to the control group in the first phase of the formalin test, whereas in the second phase only the dose of 500 mg/kg showed an antinociceptive effect. In addition, THME at doses of 300 and 500 mg/kg significantly increased the latency time in the tail flick test ( p < 0.05 and p < 0.001, respectively) and in the hot plate test ( p < 0.01 and p < 0.001, respectively) compared to the control group. Conclusions: These results show that THME had antinociceptive activity using several models of nociception, and they suggest that the effect is mediated by the participation of both peripheral and central antinociceptive mechanisms. AbstractObjective: The aim of this study was to evaluate the antinociceptive activity of the methanol extract of Tabebuia hypoleuca stems (THME). Materials and Methods: The animals were divided into 5 groups of 8 mice for each test (negative controls, positive controls, and 3 groups treated with THME at doses of 150, 300, and 500 mg/kg, p.o.). The antinociceptive effect of THME was evaluated using the writhing, formalin, tail flick, and hot plate models in mice. Results: In the writhing test, THME (150, 300, and 500 mg/kg) produced significantly ( p < 0.001) fewer writhes induced by acetic acid Significance of the Study• In this study Tabebuia hypoleuca was shown to have antinociceptive effects mediated by the participation of both peripheral and central antinociceptive mechanisms. The T. hypoleuca species could become a new therapeutic option for the treatment of pain.

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“…The method was essentially as described by Nakamura H, et al 8 Groups of six mice were used. The control group received distilled water, while the other groups received the extracts (decoction and ethanol extract) at doses of 50; 100; 150; 300 and 500 mg/kg b.w.…”

Section: Acetic Acid-induced Writhingmentioning

confidence: 99%

Anti-inflammatory Activities of Total Leaf Extracts of Ficus sycomorus L. (Moraceae) used in Traditional Medicine in the Treatment of Sickle Cell Disease

Ramde-Tiendrebeogo¹,

Ouédraogo²,

Tibiri³

et al. 2015

JYP

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Background: This study has been carried out to evaluate the in vivo anti-inflammatory, analgesic and anti-pyretic effects of an aqueous decoction and ethanol extract (95%) of Ficus sycomorus leaves. Methods: The anti-inflammatory effect was evaluated by the carrageenan-induced mice paw oedema model. The non-morphine type analgesic effect was evaluated trough acetic acid-induced writhing test. The morphine type analgesic activity was tested by mouse tail-flick test. The anti-pyretic activity was tested by induced hyperthermia in mice with brewer's yeast. Data analysis used the one way ANOVA test. Results: The anti-inflammatory effects of the two extracts, at doses of 300 and 500 mg/kg b.w., were dose dependent and comparable to those of the reference controls, indomethacin (1 mg/kg b.w.) and hydrocortisone (10 mg/kg b.w.). At the same dose, the analgesic effect of the ethanol extract on abdominal writhings induced by acetic acid, was comparable to those Lysine acetylsalicylate (LAS, 300 mg/kg b.w) and hydrocortisone (10 mg/kg b.w.) used as controls. As for the morphine type analgesic effects of the two extracts tested at doses of 300 and 500 mg / kg both were significantly higher in comparison with the blank control (p<0.05) and comparable to that of morphine (5 mg/kg b.w.) from the 75 th minute. The antipyretic activity of the extracts at the same doses was comparable to those of the LAS (300 mg/ kg b.w.) and hydrocortisone (10 mg/kg b.w.) from the third hour. Conclusion: The results obtained justify the use of the plant in traditional medicine and show the significance of Ficus sycomorus leaves in the search for new anti-inflammatory molecules in the treatment of sickle cell disease.

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The site of analgesic action of non-acidic non-steroidal anti-inflammatory drugs

Cited by 24 publications

References 0 publications

A Novel Model of Pain Sensation Using Superfused Gastrosplenic Omentum Preparation of Anesthetized Rats

A Novel Model of Pain Sensation Using Superfused Gastrosplenic Omentum Preparation of Anesthetized Rats

Antinociceptive Activity of Methanol Extract of Tabebuia hypoleuca (C. Wright ex Sauvalle) Urb. Stems

Anti-inflammatory Activities of Total Leaf Extracts of Ficus sycomorus L. (Moraceae) used in Traditional Medicine in the Treatment of Sickle Cell Disease

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