2016
DOI: 10.1007/s11427-016-0322-x
|View full text |Cite
|
Sign up to set email alerts
|

The size matters: regulation of lipid storage by lipid droplet dynamics

Abstract: Adequate energy storage is essential for sustaining healthy life. Lipid droplet (LD) is the subcellular organelle that stores energy in the form of neutral lipids and releases fatty acids under energy deficient conditions. Energy storage capacity of LDs is primarily dependent on the sizes of LDs. Enlargement and growth of LDs is controlled by two molecular pathways: neutral lipid synthesis and atypical LD fusion. Shrinkage of LDs is mediated by the degradation of neutral lipids under energy demanding condition… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

2
43
0

Year Published

2017
2017
2024
2024

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 73 publications
(45 citation statements)
references
References 132 publications
(113 reference statements)
2
43
0
Order By: Relevance
“…These results indicate that CQ and 3-MA caused accumulation of LDs in ZFL cells by suppressing autophagy. One of the main functions of lipophagy in mammals is to release FFAs from TGs as substrates for further metabolic reactions, such as b-oxidation for energy production [13]. In our present experiments, the use of CQ and 3-MA not only decreased significantly fatty acid (FA) b-oxidation, but also inhibited significantly esterification of FA into neutral lipids (mostly triglycerides [TGs]) in the ZFL cells (Figs.…”
mentioning
confidence: 48%
“…These results indicate that CQ and 3-MA caused accumulation of LDs in ZFL cells by suppressing autophagy. One of the main functions of lipophagy in mammals is to release FFAs from TGs as substrates for further metabolic reactions, such as b-oxidation for energy production [13]. In our present experiments, the use of CQ and 3-MA not only decreased significantly fatty acid (FA) b-oxidation, but also inhibited significantly esterification of FA into neutral lipids (mostly triglycerides [TGs]) in the ZFL cells (Figs.…”
mentioning
confidence: 48%
“…Synthesis of neutral lipids in the endoplasmic reticulum (ER) membrane by enzymes such as diglyceride acyltransferase 1 (DGAT1) leads to the formation of nascent LDs, which emerge as organelles partially or completely distinct from the ER [5, 6]. After formation, LDs can continue to grow by local synthesis of neutral lipids or – in certain specialized tissues like adipocytes – via fusion [5, 7]. In times of need, the neutral lipids stored in LDs can be broken down by either of two pathways, lipolysis or lipophagy [8].…”
Section: 0 Introductionmentioning
confidence: 99%
“…These aspects of LDs have been reviewed extensively ( e.g. , [1-7, 11-21]); see also the reviews in this issue by Olzmann, Mashek, Zechner and Kratky, and Yen and Reue. Yet the importance of LDs is not restricted to energy storage.…”
Section: 0 Introductionmentioning
confidence: 99%
“…Additionally, alliin reduced the size of the adipocytes, suggesting its implication in lipid metabolism by modifying its storage [36], by inhibiting lipid synthesis, or by affecting acetate incorporation into fatty acid [37,38]. Interestingly, we did not find any obvious hypolipidemic effect, despite its being widely reported [35,39] even in previous DIO models where a significant decrease of lipids was found.…”
Section: Alliin Reduces the Adipocyte Size And Improves Metabolism Lementioning
confidence: 46%