The Skin and Diabetes

Lasschuit, Joel Willem Johan; Snaith, Jennifer R; Frew, John W.

doi:10.1007/978-3-030-54779-0_18

Cited by 2 publications

(3 citation statements)

References 51 publications

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“…An algorithm for image processing of skin macules is proposed with a classification network, resulting in an accuracy of 97.5% for the four types of macules studied in this work. Vascular, petechiae, trophic changes and traumacutaneous manifestations are not taken into account in diabetic patients; however, Lasschuit et al, says that they can be some of the first indicators of diabetes and diabetic foot in patients [10], and other authors says that 60% of diabetic patients suffer from this affectation [29].…”

Section: Discussionmentioning

confidence: 99%

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Proposal of a Non-Invasive Measurement of Physical Properties of Tissues in Patients with Diabetic Foot: Measurement Experiences in Diagnosed Patients

et al. 2023

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Diabetic foot is one of the most serious complications in patients with diabetes mellitus. It is distinguished by the development of ulcerations on the sole of the foot. Before the appearance of these, patients with diabetes suffer changes in the tissues of the foot and nearby tissues. This work proposes systems that measure and identify the changes in the physical characteristics of the foot tissues in two study groups, diabetic patients and healthy subjects, with the purpose of proposing tools to physicians to follow up each patient and identify with certainty the evolution in symptoms. The results of the temperature systems show that there is an average temperature difference of ~2 °C between diabetic patients and healthy subjects. Using an electrical impedance system, a frequency window was found between 5 kHz and 22 kHz, where the impedance is significantly different (p > 0.001) between diabetic and healthy patients. The system oriented to macules on the skin is able to identify the type of macules developed by the diabetic patient. In temperature measurement with images from a smartphone, plantar temperature monitoring was achieved in at-risk areas in uncontrolled environments. The results presented in this work were obtained in a time period from 2014 to 2022. Considering the standardization of this equipment when making a diagnosis regarding the study of tissues in the diabetic foot, it will be possible to detect it early. Through differences between the measurements, we have an indicator of the patient’s evolution, and we must highlight that these systems are easy to install, easy to interpret and low cost. Currently, there are no systems with these characteristics, which is why the early detection of diabetic foot is being widely studied.

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Section: Discussionmentioning

confidence: 99%

“…Diabetes mellitus is associated with different dermatologic conditions. Dermatologic manifestations can be the first indicator of diabetes in some patients, and certain conditions may indicate poor control of the diabetic patient [10].…”

Section: Introductionmentioning

confidence: 99%

Proposal of a Non-Invasive Measurement of Physical Properties of Tissues in Patients with Diabetic Foot: Measurement Experiences in Diagnosed Patients

et al. 2023

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“…It has been reported that diabetes can cause skin manifestations in 30% of patients [6][7]. Skin problems may even be the first indicator of diabetes in some patients with diabetes [8]. An imbalance between the production of free radicals and antioxidant mechanisms in diabetes can lead to oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Effect of oral administration and topical gel application of thymol and low-level laser therapy on oxidative stress, inflammatory biomarkers and dermatitis in patients with type 2 diabetes mellitus

Martirosyan¹,

Jahanbakhshi

Ashoori

et al. 2022

Bioactive Compounds in Health and Disease

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Background: Unmanaged diabetes mellitus, as a chronic metabolic disease, has dangerous consequences. The consequences of diabetes can be delayed and controlled by using antioxidants and anti-inflammatory substances in the food compounds. Objective: One of the main objectives of this study was to evaluate thymol administration and low-level laser therapy on the change of inflammatory and, oxidative indicators, and lipid profiles in patients with type 2 diabetes. Another aim was to study the effect of thymol oil extract on dermatitis.Methods: Thirty volunteers with type 2 diabetes and thirty healthy volunteers as controls were selected. Blood samples were taken from all subjects before the study. The diabetic group was divided into four groups: untreated, treated with low-level laser, treated with thymol (25 mg/kg/30 days) and treated with thymol and laser. Glucose, advanced glycation end products, malondialdehyde, oxidized low level laser, reactive oxygen species, peroxide hydrogen, total cholesterol, triglyceride, and inflammatory cytokines such as tumor necrosis factor alpha, interleukin-1 beta and interleukin-1 alpha were measured and compared between diabetic and control groups and within diabetic groups. Thymol gel oil extract (0.5%) was studied in reduction of dermatitis in the feet of the diabetic group.Results: Thymol administration, along with low-level laser therapy, reduced levels of cytokines except for interleukin-1 alpha, total cholesterol, triglycerides, advanced glycation end products, hydrogen peroxide, malondialdehyde, and oxidized low density level lipoprotein (P value < 0.05). The effect of 0.5% thymol oil as a gel on the reduction of dermatitis was not significant.Conclusion: Thymol administration and thymol gel as well as low-level laser therapy, as adjunctive methods, through the reduction of free radicals and oxidative stress can be useful in controlling and reducing the diabetes complications. Keywords: Diabetes mellitus, Thymol, Topical gel, Low-level laser therapy, Dermatitis

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The Skin and Diabetes

Cited by 2 publications

References 51 publications

Proposal of a Non-Invasive Measurement of Physical Properties of Tissues in Patients with Diabetic Foot: Measurement Experiences in Diagnosed Patients

Proposal of a Non-Invasive Measurement of Physical Properties of Tissues in Patients with Diabetic Foot: Measurement Experiences in Diagnosed Patients

Effect of oral administration and topical gel application of thymol and low-level laser therapy on oxidative stress, inflammatory biomarkers and dermatitis in patients with type 2 diabetes mellitus

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