The skin‐depigmenting potential of Paeonia lactiflora root extract and paeoniflorin: <i>in vitro</i> evaluation using reconstructed pigmented human epidermis

Qiu, Jie; Chen, M.; Liu, J.; Huang, Xin-Zhu; Chen, J.; Zhou, Li-Fei; Ma, Jin-Yeul; Sextius, Peggy; Pena, Ana‐Maria; Cai, Zhenzi; Jeulin, Séverine

doi:10.1111/ics.12309

Cited by 29 publications

(26 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cellular melanin content was significantly lower following treatment with the extract (28 and 30 %) or paeoniflorin (77) (30 and 10 %) than that obtained with the control (7 % and 26 %), as indicated by the melanin density determined via multiphoton microscopic analysis. P. lactiflora extract, paeoniflorin (77) (120 and 200 µg/mL), and 4-n-butylresorcinol reduced melanin content by 23 % and 39 %, respectively, 23 % and 27 %, respectively, and 24 % and 40 %, respectively [54].…”

Section: Enzyme Inhibition Cell Culturementioning

confidence: 98%

“…Cudrania tricuspidata (Carrière) Bur. ex Lavallée (Moraceae) extract containing oxyresveratrol (54) and trans-dihydromorin (55) exhibited inhibitory effects against cellular melanin production in Melan-a cells. The safety margin of trans-dihydromorin was wider (10-100 µM) than that of oxyresveratrol (54) (10-20 µM).…”

Section: Enzyme Inhibition Cell Culturementioning

confidence: 99%

“…Panduratin A (68) more potently inhibited melanin production in Melan-a cells than kojic acid (4) 9, rosmarinic acid (69), and gallic acid (70) were the main active phenolics in the extract [43,44]. Mulberry (Morus alba L., Moraceae) is widely used to treat skin hyperpigmentation due to its high phenolic content, particularly the active compound oxyresveratrol (54). Mulberrosides are other active compounds isolated from mulberry, with mulberroside F (71) exhibiting more potent activity against mushroom TYR than kojic acid (4) (IC 50 = 0.29 at 1.30 µg/mL), although its activity against mammalian TYR is weaker (IC 50 = 68.3 at 58.5 µg/mL) [45].…”

Section: Enzyme Inhibition Cell Culturementioning

confidence: 99%

See 2 more Smart Citations

Plants and Natural Products for the Treatment of Skin Hyperpigmentation – A Review

Kanlayavattanakul

Lourith

2018

Planta Med

View full text Add to dashboard Cite

Skin hyperpigmentation is caused by several factors that upregulate melanogenesis. Plants and natural products with skin-whitening effects are gaining interest among consumers and researchers because they are perceived to be milder, safer, and healthier than synthetic alternatives. This review extensively summarizes the status of plants and natural products currently used in skin-whitening cosmetics as well as potential candidates for future use, because the scope of natural choices for efficient treatment of skin hyperpigmentation is rapidly widening. Biological activities of plants and natural extracts are therefore available for cosmetic formulators and dermatologists interested in naturally derived ingredients for skin hyperpigmentation treatment and in accordance with the consumers' preferences and expectations upon natural cosmetic products.

show abstract

Section: Enzyme Inhibition Cell Culturementioning

confidence: 98%

Section: Enzyme Inhibition Cell Culturementioning

confidence: 99%

Section: Enzyme Inhibition Cell Culturementioning

confidence: 99%

See 1 more Smart Citation

Plants and Natural Products for the Treatment of Skin Hyperpigmentation – A Review

Kanlayavattanakul

Lourith

2018

Planta Med

View full text Add to dashboard Cite

show abstract

“…Paeoniflorin attenuated ultraviolet B-induced apoptosis in human keratinocytes (Kong et al, 2016) and had skin-depigmenting potential, which may be helpful for plantar hyperpigmentation due to CAP (Qiu et al, 2016;Tognetti, Fimiani, & Rubegni, 2015). It protected sensory nerves from demyelination via activation of the adenosine A1 receptor and inhibited chemotherapy-induced peripheral neuropathic pain (Andoh, Kobayashi, Uta, & Kuraishi, 2017).…”

Section: Paeoniae Radix Albamentioning

confidence: 99%

Herbal medicine for hand–foot syndrome induced by fluoropyrimidines: A systematic review and meta‐analysis

Deng

Sun

2018

Phytotherapy Research

View full text Add to dashboard Cite

The aims of this study were to evaluate the efficacy of herbal medicine for the prevention and management of hand-foot syndrome (HFS) induced by fluoropyrimidines and to identify herbs associated with HFS alleviation for further research. The PubMed, Cochrane, Springer, China National Knowledge Infrastructure, and Wanfang databases were searched up to May 2017 for randomized controlled trials (RCTs) that evaluated herbal medicine for relieving HFS in patients undergoing fluoropyrimidine-based chemotherapy. Study evaluation and synthesis methods were in accordance with the Cochrane Handbook, and data were analyzed using RevMan 5.3. In total, 35 RCTs (2,668 participants) were included. Meta-analysis showed that the addition of herbal medicine significantly reduced the incidences of all-grade and high-grade HFS. The total effective rate and complete remission rate of HFS patients increased significantly with herbal medicine arm. Further sensitivity analysis identified Paeoniae Radix Alba, Carthami Flos, Cinnamomi Ramulus, and Glycyrrhizae Radix et Rhizoma as being consistently associated with significant reductions in HFS incidence without important heterogeneity. However, the lack of blinding in most studies may have led to overestimation of these effects. More high-quality RCTs and experimental research are needed to confirm and investigate the efficacy of the herbs identified in this study.

show abstract

“…Quercetin (9), rosmarinic acid (69), and gallic acid (70) were the main active phenolics in the extract [43,44]. Mulberry (Morus alba L., Moraceae) is widely used to treat skin hyperpigmentation due to its high phenolic content, particularly the active compound oxyresveratrol (54). Mulberrosides are other active compounds isolated from mulberry, with mulberroside F (71) exhibiting more potent activity against mushroom TYR than kojic acid (4) (IC 50 = 0.29 at 1.30 µg/mL), although its activity against mammalian TYR is weaker (IC 50 = 68.3 at 58.5 µg/mL) [45].…”

Section: Enzyme Inhibition Cell Culturementioning

confidence: 99%

Untitled

2018

Planta Med

View full text Add to dashboard Cite

IntroductionSkin hyperpigmentation is caused by several factors (i.e., UV radiation, radicals, inflammatory mediators, and hormones) as depicted in ▶ Fig. 1. Briefly, UV radiation causes skin hyperpigmentation by stimulating keratinocytes to secrete α-MSH, a small peptide hormone derived from proopiomelanocortin. Consequently, α-MSH binds to MC1R expressed on melanocyte surfaces and thereafter induces melanogenesis via multiple signaling pathways resulting from cAMP, PKA, CREB, and MITF activity. MITF is a key transcription factor regulating the transcription of melanogenic enzymes (i.e., TYR, TRP-1, and TRP-2). In addition, UV radiation modulates Nrf2 and further activates MAPKs. MAPKs consist of three subtypes: stress-activated protein kinases/JNK, p38, and ERKs. JNK and p38 kinases are stimulated by pro-inflammatory cytokines and environmentally induced stresses such as exposure to UV irradiation, heat, and hydrogen peroxide, resulting in DNA damage. Melanogenesis is controlled by MAPKs, with MITF being activated by p38 phosphorylation. By contrast, ERK activation inhibits melanin synthesis by downregulating MITF expression [1].Preliminary evaluation of skin-whitening agents is best achieved through in vitro assays including cell culture assessments. In this context, plant-based and naturally derived skinwhitening agents have been examined for their biological activities and safety. Scientific literature provided by the American Chemical Society, J-STAGE, Karger, ScienceDirect, Taylor and Francis, Thieme Medical, and Wiley-Blackwell publishers included those that are searchable using Google Scholar published from 1997 to 2017 and cosmetic suppliersʼ databases. The literatures were searched on active, activity, bio-based, cosmeceuticals, hyperpigmentation, herb, melanin, melanogenesis, melanoma, plant, natural product, skin-lightening, and skin-whitening. Only articles in the English language have been selected. Unclear botanical identification, inadequate or insufficient data in terms of ABSTR AC T Skin hyperpigmentation is caused by several factors that upregulate melanogenesis. Plants and natural products with skin-whitening effects are gaining interest among consumers and researchers because they are perceived to be milder, safer, and healthier than synthetic alternatives. This review extensively summarizes the status of plants and natural products currently used in skin-whitening cosmetics as well as potential candidates for future use, because the scope of natural choices for efficient treatment of skin hyperpigmentation is rapidly widening. Biological activities of plants and natural extracts are therefore available for cosmetic formulators and dermatologists interested in naturally derived ingredients for skin hyperpigmentation treatment and in accordance with the consumersʼ preferences and expectations upon natural cosmetic products.

show abstract

The skin‐depigmenting potential of Paeonia lactiflora root extract and paeoniflorin: in vitro evaluation using reconstructed pigmented human epidermis

Cited by 29 publications

References 35 publications

Plants and Natural Products for the Treatment of Skin Hyperpigmentation – A Review

Plants and Natural Products for the Treatment of Skin Hyperpigmentation – A Review

Herbal medicine for hand–foot syndrome induced by fluoropyrimidines: A systematic review and meta‐analysis

Untitled

Contact Info

Product

Resources

About