The skin-photosensitizing furocoumarins

Synthesis, spectral characterization, in vitro microbial and cytotoxic studies of lanthanum(III) and thorium(IV) complexes with 1,2,4-triazole Schiff bases

“…Table I. Elemental analysis and molar conductance data of Schiff bases (I-IV) and their La(III) and Th(IV) complexes (1)(2)(3)(4)(5)(6)(7)(8) …”

“…Triazole derivatives [3][4][5][6] are known to possess antibacterial, fungicidal, hypotensive and hypothermic activities. In addition to 1,2,4-triazole derivatives coumarin derivatives display an additional significant biological [7][8][9][10][11] and pharmacological [12,13] properties. Many of these compounds possess antibacterial [12], antifungal [13] and insecticidal [10] activities and the hydroxycoumarins are the typical phenolic compounds and therefore, act as potent metal chelators and free redical scavengers.…”

Sites of Termination ofin VitroDNA Synthesis on Psoralen Phototreated Single-stranded Templates

“…Cycloadducts between psoralens and pyrimidine bases are formed by irradiation of a complex between DNA and psoralen with 365 nm light (Musajo andRodighiero 1972, Isaacs et al 1977). Although active excision and recombination repair mechanisms exist in the cells (see Hanawalt et al 1979, Song andTapley 1979) which restore the normal base sequence, a psoralen cycloadduct can be encountered by the replicating machinery during DNA synthesis.…”

Structural specificity for the photoinactivation of nucleic acids by furocoumarins

“…We recall erythema on human or guinea-pig skin [1][2][3][4][5], death of bacteria [6][7][8], formation of mutants in Sarcina lutea cultures [9] and of giant ceils in mammalian cells adapted to in vitro growth [ 10], inactivation of DNA viruses [11], destruction of the tumor-transmitting capacity of the Ehrlich ascites tumor ceils [12] and disorders in the development of sea-urchin eggs fertilized by sperm irradiated in the presence of furocoumarins [13].…”