The SKN-1 hunger games: May the odds be ever in your favor

Lynn, Dana A.; Curran, Sean P.

doi:10.1080/21624054.2015.1078959

Cited by 8 publications

(9 citation statements)

References 41 publications

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“…It is clear that diet and genetics play important roles in the regulation of metabolism, healthspan, and lifespan (Lynn and Curran, 2015). However, our understanding of these interactions is limited by studies that only query single gene mutations on one particular diet.…”

Section: Gene-diet Interactionsmentioning

confidence: 99%

Gene-diet interactions and aging in C. elegans

Yen

Curran

2016

Experimental Gerontology

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Diet is the most variable aspect of life history, as most individuals have a large diversity of food choices, varying in the type and amount that they ingest. In the short-term, diet can affect metabolism and energy levels. However, in the long run, the net deficiency or excess of calories from diet can influence the progression and severity of age-related diseases. An old and yet still debated question is: how do specific dietary choices impact health- and lifespan? It is clear that genetics can play a critical role — perhaps just as important as diet choices. For example, poor diet in combination with genetic susceptibility can lead to metabolic disorders, such as obesity and type 2 diabetes. Recent work in Caenorhabditis elegans has identified the existence of diet-gene pairs, where the consequence of mutating a specific gene is only realized on specific diets. Many core metabolic pathways are conserved from worm to human. Although only a handful of these diet-gene pairs has been characterized, there are potentially hundreds, if not thousands, of such interactions, which may explain the variability in the rates of aging in humans and the incidence and severity of age-related diseases.

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Section: Gene-diet Interactionsmentioning

confidence: 99%

Gene-diet interactions and aging in C. elegans

Yen

Curran

2016

Experimental Gerontology

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“…Diet is one of the most variable aspect of life between individuals and may account for a significant portion of the non-genetic effectors of lifespan and healthspan [11,12,[23][24][25][26][27][28][29][30][31][32][33][34][35]. Tea, derived from the leaves of the evergreen plant Camellia sinensis, has attracted significant attention worldwide for its antioxidant and health benefits [36,37].…”

Section: Introductionmentioning

confidence: 99%

Oolonghomobisflavans from Camellia sinensis increase Caenorhabditis elegans lifespan and healthspan

Duangjan

Curran

2021

GeroScience

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Tea polyphenols are widely considered as excellent antioxidant agents which can contribute to human health and longevity. However, the identification of the active biomolecules in complex tea extracts that promote health and longevity are not fully known. Here we used the nematode Caenorhabditis elegans to analyze the health benefits and longevity effects of Camellia sinensis oolong tea extracts (QFT, NFT, and CFT) and oolonghomobisflavan A and oolonghomobisflavan B, which are present in oolong tea extracts. Our results showed that oolong tea extracts and oolonghomobisflavans prolong lifespan and improved healthspan by curtailing the age-related decline in muscle activity and the accumulation of age pigment (lipofuscin). We found that the lifespan and healthspan promoting effects of oolong tea extracts and oolonghomobisflavans were positively correlated with the stress resistance via DAF-16/FOXO transcription factor. Furthermore, oolong tea extracts and oolonghomobisflavans displayed protective effects against Aβ- and polyQ-induced neuro/proteotoxicity. Overall, our study provides new evidence to support the health benefits of oolong tea and importantly identify oolonghomobisflavans as potent bioactive molecules that promote health when supplemented with a normal diet. As such, oolonghomobisflavans represent a valuable new class of compounds that promote healthy aging.

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“…Environment and nutritional status have been explored as important regulators in developmental processes and metabolic pathways [50][51][52]. The effects of caffeine, the most widely consumed diet component, have been studied in a C. elegans model to understand its physiological roles both at the molecular and organismal level [10][11][12][13][14][15][16]53,54].…”

Section: Discussionmentioning

confidence: 99%

Effects of Phosphoethanolamine Supplementation on Mitochondrial Activity and Lipogenesis in a Caffeine Ingestion Caenorhabditis elegans Model

et al. 2020

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Caffeine intake is strongly linked to lipid metabolism. We previously reported the age-dependent physiological effects of caffeine intake in a Caenorhabditis elegans model. Since nutritional status can actively influence metabolism and overall health, in this study, we evaluated the effect of caffeine intake on lipid metabolism in adult-stage C. elegans. We found that, in C. elegans, fat storage and the level of phosphoethanolamine (PE) were significantly reduced with caffeine intake. In addition, mitochondrial activity decreased and mitochondrial morphology was disrupted, and the expression of oxidative stress response genes, hsp-6, gst-4, and daf-16, was induced by caffeine intake. Furthermore, the level of an energy metabolism sensor, phospho-AMP-activated protein kinase, was increased, whereas the expression of the sterol regulatory element binding protein gene and its target stearoyl-CoA desaturase genes, fat-5, -6, and -7, was decreased with caffeine intake. These findings suggest that caffeine intake causes mitochondrial dysfunction and reduces lipogenesis. Interestingly, these changes induced by caffeine intake were partially alleviated by PE supplementation, suggesting that the reduction in mitochondrial activity and lipogenesis is in part because of the low PE level, and proper dietary supplementation can improve organelle integrity.

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The SKN-1 hunger games: May the odds be ever in your favor

Cited by 8 publications

References 41 publications

Gene-diet interactions and aging in C. elegans

Gene-diet interactions and aging in C. elegans

Oolonghomobisflavans from Camellia sinensis increase Caenorhabditis elegans lifespan and healthspan

Effects of Phosphoethanolamine Supplementation on Mitochondrial Activity and Lipogenesis in a Caffeine Ingestion Caenorhabditis elegans Model

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