The small cell carcinoma neuroendocrine type of the larynx—Case report

Pytal, Maria; Olejniczak, Izabela; Kupnicki, Piotr; Trenda-Lewy, Iwona; Michalecki, Łukasz

doi:10.1016/j.poamed.2016.06.003

Cited by 4 publications

(4 citation statements)

References 13 publications

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“…In contrast, it seems that cigarettes are less significant in the extrapulmonary variant of the disease ( 9 , 10 ). The disease may manifest with multiple symptoms, including hoarseness, dyspnea, or dysphagia ( 11 ). Poorly differentiated NECs are associated with elevated mitotic activity and necrosis ( 12 ).…”

Section: Discussionmentioning

confidence: 99%

Small cell carcinoma with neuroendocrine differentiation of subglottic larynx- a case report

Becht,

Kiełbowski,

Żychowska

et al. 2023

Front. Oncol.

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Small cell cancer (SCC) is a neuroendocrine neoplasm, which is most frequently found in the lungs. Extrapulmonary location of SCC is rare and may involve 2.5-5% of SCCs. We present a case of a 31-year-old male patient with an extremely uncommon subglottic SCC. The patient was qualified for a radical sequential chemoradiotherapy. After treatment, patient’s condition suggested complete remission. Recurrence was detected one year later, and the disease rapidly progressed, despite a second line chemotherapy. The patient died 29 months after initial diagnosis. This case aims to raise awareness on the aggressive laryngeal SCC and its good response to first line chemotherapy composed of cisplatin and etoposide, followed by radiotherapy.

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Section: Discussionmentioning

confidence: 99%

Small cell carcinoma with neuroendocrine differentiation of subglottic larynx- a case report

Becht,

Kiełbowski,

Żychowska

et al. 2023

Front. Oncol.

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“…NEC are rare, the atypical type being more frequent and the carcinoid type being less frequent. Five hundred cases of primary NEC of the larynx have been reported in the literature [ 9 , 10 ], of which 160 cases were classified as SCC [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Primary small cell carcinoma of the larynx. Survival time of 47 months. Case report

Raposo

Marco²,

García-Solano³

et al. 2018

Annals of Medicine and Surgery

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Small cell carcinoma (SCC) of the larynx is a rare type of neuroendocrine carcinoma (NEC), few cases of which have been described in the literature. The prognosis for this type of carcinoma is poor, with a survival time typically not exceeding two years. We describe the case of a 54-year-old male patient with a primary tumor in the right ventricular band and a biopsy compatible with SCC. The patient underwent radiotherapy (RT) and concomitant chemotherapy (QT) and, after a relapse at 17 months, underwent total laryngectomy with bilateral neck dissection. The survival time was 47 months. Further studies are required to elucidate the possible causes of the better prognosis in some cases.

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“…The recent World Health Organization book simplified former classifications dividing neuroendocrine tumors in 3 subtypes: well-differentiated neuroendocrine carcinoma (typical carcinoid, neuroendocrine carcinoma grade I), moderately-differentiated neuroendocrine carcinoma (atypical carcinoid tumor, neuroendocrine carcinoma grade II) and poorly-differentiated neuroendocrine carcinoma (small cell neuroendocrine carcinoma and large cell neuroendocrine carcinoma) 1 . The most frequent type is the atypical carcinoid, while the typical carcinoid is a very rare tumor 2,3 . Laryngeal tumors with neuroendocrine morphology are a rare and diverse group of neoplasms, which share specific pathological and immunohistochemical features, with prognosis dependent on the tumor type.…”

Section: Introductionmentioning

confidence: 99%

“…They have received increasing attention in recent years because of a controversial terminology that was in need of standardization 4 . Small cell carcinoma neuroendocrine type (SCC-NET) is a rare tumor (2.5-4% of all small cell carcinomas) and, according to one study, during the past 30 years only 160 cases of primary small cell carcinoma of the larynx have been published worldwide 2 . Most of the patients are between 60 to 70 years of age, with the male population being more commonly affected 5 .…”

Section: Introductionmentioning

confidence: 99%

Primary neuroendocrine small cell carcinoma in larynx: case report and literature review

Evsei

Iosif

Enache

et al. 2017

Romanian Journal of Rhinology

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Background. Neuroendocrine tumors of the larynx represent a rare group of neoplasms characterized by pathological and biological heterogeneity. The histological and immunohistochemical diagnosis is the most important step in the appropriate management of these tumors and the prognosis varies according to histological types. Conventional anatomical and functional imaging can be complementary for diagnosis, staging and monitoring of treatment response. Material and methods. Here we report on a case of a laryngeal neuroendocrine small cell carcinoma occurring in a 67-year-old man who was referred to our clinic for clinical reevaluation, diagnosis and treatment. The clinical presentation, the histopathological and immunohistochemical examination and management of this kind of tumor are highlighted. Conclusion. Small cell neuroendocrine carcinomas are very aggressive neoplasms. Patients could benefit from surgery, but radiotherapy and chemotherapy remain the treatment of choice. Very low incidence of neuroendocrine tumors in the larynx and specifically very poor prognosis of neuroendocrine small cell carcinoma encouraged an extensive literature review.

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The small cell carcinoma neuroendocrine type of the larynx—Case report

Cited by 4 publications

References 13 publications

Small cell carcinoma with neuroendocrine differentiation of subglottic larynx- a case report

Small cell carcinoma with neuroendocrine differentiation of subglottic larynx- a case report

Primary small cell carcinoma of the larynx. Survival time of 47 months. Case report

Primary neuroendocrine small cell carcinoma in larynx: case report and literature review

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