The So-Called Reticulohistiocytoma of the Skin..

Davies, B. T.; Wood, S.

doi:10.1111/j.1365-2133.1955.tb12721.x

Cited by 37 publications

(6 citation statements)

References 13 publications

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“…An elevated, moderately well circumscribed nodular lesion, without encapsulation, occupying the entire dermis (Fig 1). 2. A basically haphazard polymorphous pattern of large, bizarre, multinucleated cells and sarcoma¬ like cells, occasionally in fascicular arrangement.…”

Section: Resultsmentioning

confidence: 99%

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Pseudosarcomatous Reticulohistiocytoma

Gordon¹

1964

Arch Dermatol

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Section: Resultsmentioning

confidence: 99%

“…(2) The lesions are possibly a distinct entity. (3) These lesions represent an example of a dis¬ crepancy between apparently benign biological behavior and malignant histological characteristics.…”

Section: Introductionmentioning

confidence: 99%

Pseudosarcomatous Reticulohistiocytoma

Gordon¹

1964

Arch Dermatol

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“…Unlike multicentric reticulohistiocytosis, the lesions are solitary or few in number and involve the head and neck principally. In a series of 44 patients from the Armed Forces Institute of Pathology, approximately 15% had multiple lesions (35)(36)(37). Cutaneous ulcerating and nonulcerating nodules of reticulohistiocytosis have also been associated with a peculiar IgG paraproteinemia in the absence of arthritis or other systemic involvement (38).…”

Section: Multicentric Reticulohistiocytosismentioning

confidence: 99%

“…No Langerhans' cells are found (16,33,34). In the reticulohistiocytic granuloma, the pathology is similar; however, one sees more of a neutrophilic infiltrate and spindle cell stroma than in the lesions of multicentric reticulohistiocytosis (35)(36)(37)16).…”

Section: Multicentric Reticulohistiocytosismentioning

confidence: 99%

Cutaneous Histiocytosis Syndromes

Roper

Spraker

1985

Pediatric Dermatology

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Cutaneous histiocytosis may take two principal forms. It is either a benign proliferative process or a relentless, progressive process with a poor prognosis. In histiocytic medullary reticulosis, histiocytes demonstrate nuclear atypia and the outcome is uniformly fatal. Benign cephalic histiocytosis X causes lesions similar to those of histiocytosis X, but Langerhans' cells are absent. In congenital self-healing histiocytosis X, the Letterer-Siwe-like cutaneous infiltrate contains Langerhans' cells, but the lesions heal spontaneously without treatment. The nodular cutaneous lesions of juvenile xanthogranuloma appear in infancy and resolve without treatment; however, the higher percentage (10%) of associated ocular lesions may lead to glaucoma and blindness. In histiocytosis X, the cutaneous lesions show a marked proliferation of Langerhans' cells, with prognosis dependent on the patient's age and the extent of organ dysfunction. Patients who survive the acute form of the disease may develop diabetes insipidus, growth retardation, pulmonary fibrosis, and biliary cirrhosis. A subtle immunologic defect has been identified in patients with histiocytosis X, yet the pathogenesis of the disease is still speculative. Familial disease occurring in early infancy should be differentiated from complete or partial immunodeficiency syndromes. Guidelines for evaluating patients with cutaneous histiocytosis are reviewed.

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“…Although Barrow The cause of MR remains an enigma. Various views about the pathogenesis of MR have been described (5,6,8,9,(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32), but none are conclusive.…”

Section: Electron Microscopic Studiesmentioning

confidence: 99%

A Study of Multicentric Reticulohistiocytosis (Lipoid Dermatoarthritis)

Ikezawa

Nakajima

1976

The Journal of Dermatology

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A case of multicentric reticulohistiocytosis is presented, with typical clinical, roentgenologic, and histologic features. The characteristic giant cells were seen in skin nodules, mucosal nodules, synovial and bony lesions of the joints, and tenosynovial cysts. Corticosteroid therapy produced a subjective improvement, but the arthritis mutilans did not improve. Laboratory studies showed iron‐deficiency anemia, hypertriglyceridemia (hyperprebetalipo‐proteinemia), a low response to the unstimulated and stimulated nitroblue tetrazolium test of neutrophils, and a decreased activity in the glucose‐6‐phosphate dehydrogenase of polimorphonuclear leucocytes before corticosteroid therapy. The histochemical examination of the material in the giant cells showed a lipid (a phospholipid and a neutral fat), and a polysaccharide attached to a protein (a muco‐ or glycoprotein). Electron microscopic studies of the giant cells indicated that their cytoplasm contained numerous dense granules clustered in the vicinity of the Golgi apparatus. In some areas the granules appeared to be developing from the Golgi vesicles and cisternas. It seemed likely that the storage material was produced within the giant cells. We also discussed the pathogenesis of this disorder.

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The So-Called Reticulohistiocytoma of the Skin..

Cited by 37 publications

References 13 publications

Pseudosarcomatous Reticulohistiocytoma

Pseudosarcomatous Reticulohistiocytoma

Cutaneous Histiocytosis Syndromes

A Study of Multicentric Reticulohistiocytosis (Lipoid Dermatoarthritis)

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