Sexual education in children with Down syndrome is often ignored by parents, even though the needs and development process children are the Down syndrome same as other normal children. The purpose of this study was to determine the materials and methods used by parents in providing sexual education to children with Down syndrome. This research is a qualitative research, data collection is done by interview and observation. Interviews were conducted with parents who havechildren Down syndrome aged 5-40 years with low education. Data analysis was carried out in three stages, namely data reduction, data display and conclusion drawing. Data verification is done by means of observation, persistence of observation and triangulation of sources and time. The results showed that: 1) sexual education material for people with Down syndrome, namely, a) ages 0-6 years parents introduce body anatomy in the form of gender differences, apply masculinity and femininity to children, educate in caring for the body, decorate and dress, socialize same-sex and intertype procedures for chatting in the family. b) 7-10 years olds are given the habit of covering their intimate parts, educating children's faith, separating children's beds, and educating them to maintain genital hygiene. c) ages 10-14 years away from sexual stimulation. d) ages 14-21 years avoid adultery. 2) The methods applied are a) playing methods, b) peers, c) demonstrations or practices, d) exemplary, e) direct introduction, f) lectures, g) parables.