Distribution, means, and standard deviations of the initial R wave in lead aVR of the electrocardiogram are investigated in 1,563 healthy U.S.A., Canadian, and Japanese men, ages 18 to 60 years, and on 448 healthy U.S.A., Canadian, and Japanese women, ages 17 to 51 years, and in samples of cardiac pathology.Findings in the normal group included an initial R wave in about 50% of the group, no significant effect of age, sex, or race on the mean initial R-wave amplitude in lead aVR or its distribution, or on the upper 98% normal limit of the initial R wave, a decrease of the mean R amplitude in aVR with clockwise rotation of the transitional zone, and a highly significant correlation of R amplitude in aVR to that of R in V1, Q3, and Q in aVF, but too low for reliable prediction.Right ventricular hypertrophy, anterior wall myocardial infarction, and hypertensive