The specific binding of broxaterol, a new β2-selective agonist, to β-adrenoceptors

Sala, Roberto; Moriggi, Ermanno; Bella, D. Della; Carenzi, A.

doi:10.1016/0014-2999(91)90785-o

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1992

2025

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Cited by 7 publications

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Asthma and COPD: A Focus on β-Agonists – Past, Present and Future

Baker,

Shaw

2023

Handbook of Experimental Pharmacology

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Asthma and COPD: A Focus on β-Agonists – Past, Present and Future

Baker,

Shaw

2023

Handbook of Experimental Pharmacology

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Modulation of neurally mediated airway microvascular leakage in guinea-pig airways byβ 2 agonists

Hui

Ventresca

Brown³

et al. 1992

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The effect of two beta 2-adrenoceptor agonists, salbutamol (100 micrograms/kg i.v.) and broxaterol (100 micrograms/kg i.v.), on airway microvascular leakage induced by vagal stimulation was studied in anaesthetised guinea pigs. Airway microvascular leakage was measured by Evans blue extravasation. Broxaterol, but not salbutamol, inhibited Evans blue dye extravasation at all airway levels, an effect prevented by pretreatment with propranolol (1 mg/kg). Neither of the beta 2-agonists had any effect on substance P-induced Evans blue dye extravasation. Broxaterol inhibits the prejunctional release of tachykinins from airway sensory nerves by stimulation of beta-receptors. The mechanism by which beta-adrenoceptor agonists prevent airway microvascular leakage deserves further study.

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