The specific capsular polysaccharide of Streptococcus pneumoniae type 15F

Structural Characterization of Streptococcus pneumoniae Serotype 9A Capsule Polysaccharide Reveals Role of Glycosyl 6-O-Acetyltransferase wcjE in Serotype 9V Capsule Biosynthesis and Immunogenicity

“…6) (13), and 11D. 3 The reported PS structure of serotype 15F capsule contains 2 M equivalents of unplaced O-acetate groups (25). As 15F capsule contains ␤Gal(1-4)␤Glc identical to 11A, we hypothesize that 15F wcjE also mediates ␤Gal 6-O-acetylation, although further work is necessary to examine this proposal.…”

Immunogenicity and immunochemistry ofStreptococcus pneumoniae capsular polysaccharides

“…$15F and $15A contain the same sequence of sugars in a linear arrangement (Perry et al 1982;Carroff & Perry 1984), whereas $15B and $15C have a branched structure (Table 2; 24-27), with a core antigen identical to $14. As expected, $15B gives a strong cross-reaction in anti-S14 sera, but $15C only gives rise to a mild reaction (Heidelberger 1983).…”

Cross-reactions of polysaccharides of fungi, molds, and yeasts in anti-pneumococcal and other antisera

“…The polysaccharide has Man, GlcUA, and acetyl 2:1:1, but the linkages are not yet known (M. E. Slodki, Peoria, IL, personal communication). Since Man and Glc are partially equivalent immunologically, one might risk the following allocations: for D-Man, a portion of the linkages may be 1,3, as is D-Glc in PnS6 (34) and at least part of the D-Glc in PnS9 (18-20), PnS15 (47), and PnS20 (23). Part of the D-GlcUA may also form an aldobiouronic acid -*4)-D-GlcUA-(1--*3)-D-Man-(1-, like the D-Glc analog in PnS9.…”