The Specificity of Leukocyte and Platelet Alloantibodies in Sera of Patients with Nonhemolytic Transfusion Reactions

Heinrich, D.; Mueller‐Eckhardt, C.; Stier, W.

doi:10.1111/j.1423-0410.1973.tb03535.x

Cited by 34 publications

(12 citation statements)

References 15 publications

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“…In fact, HLA antibodies seem to be more often responsible than granulocyte-specific anti bodies. This supports the results of Heinrich et al [1973], who came to the same conclu sion.…”

Section: Discussionsupporting

confidence: 90%

“…Like other authors [Goodman and Masaitis, 1967;Ahrons, 1971;Heinrich et al, 1973;Nymand, 1969;Décary et al, 1984], we found that the sera of female patients contained a greater diversity of alloantibodies than those of male patients, which can be explained by the additional immunizing in fluence of pregnancy. In fact, all the female patients whose sera were tested had been pregnant (table I).…”

Section: Discussionsupporting

confidence: 87%

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The Serology of Febrile Transfusion Reactions

Rie¹,

Dalen²,

Engelfriet³

et al. 1985

Vox Sanguinis

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Sera from 40 patients with febrile, nonhemolytic transfusion reactions were tested for the presence of alloantibodies using a number of techniques, including immunofluorescence tests on granulocytes, lymphocytes and platelets, a modified NIH lymphocytotoxicity test and the leukocyte agglutination test. Cells of at least 9 donors were used as target cells. Alloantibodies were detected in all sera. The frequency of the occurrence of antibodies was not much higher in sera obtained about 1 month after the transfusion reaction as in sera obtained within 4 days. Most of these antibodies were anti-HLA, but quite frequently platelet-specific antibodies were found, and sometimes these were the only antibodies detected. Granulocyte-specific antibodies were the least frequent. The nature of the antibodies was specified by their difference in reactivity with the cells of multiple donors, by applying panels of cells from typed donors and by absorption and elution experiments. It appeared that not only granulocyte-specific but also HLA- and perhaps platelet-specific antibodies may be responsible for a febrile transfusion reaction. We did not find that the occurrence of rigors, together with fever, was associated with particular serologic results.

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“…In fact, HLA antibodies seem to be more often responsible than granulocyte-specific anti bodies. This supports the results of Heinrich et al [1973], who came to the same conclu sion.…”

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 87%

The Serology of Febrile Transfusion Reactions

Rie¹,

Dalen²,

Engelfriet³

et al. 1985

Vox Sanguinis

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“…The problem has been that the sensitivity of the techniques for detecting platelet isoantibodies have been relatively poor. Complement-fixing platelet isoantibodies have been identified in 10-60% of multitransfused patients (3,14,15). Isoantibodies as detected by lymphocytoxicity or other currently available techniques are identified in about 30% of this group of patients (15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

Detection of platelet isoantibodies by (3H)serotonin platelet release and its clinical application to the problem of platelet matching.

Gockerman¹,

Bowman²,

Conrad³

1975

J. Clin. Invest.

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A B S T R A C T The detection of platelet isoantibodies by the release of ['H]serotonin from platelets has been evaluated. The conditions for optimal release of ['H]serotonin with platelet isoantibodies using a microtechnique have been defined. A group of cardiac surgery patients were followed pre-and post-transfusions, with 48% developing a positive serotonin release assay. Of these patients, 16% also had a platelet complement-fixing and/or lymphocytotoxic isoantibody. There was variation in the degree of correlation between ['H]serotonin release and lymphocytotoxicity using individual National Institutes of Health typing serum. The matching obtained between family members by both techniques showed a close correlation when each technique was evaluated separately using the same NIH typing serum. The detection of isoantibodies in patients with hematological malignancies correlated with the unresponsiveness to unmatched platelet transfusions in 15 out of 17 cases. The use of the patient's isoantibody to matched platelets of family members by ['H]serotonin release correlated well with the clinical response to transfusion with these platelets. The data suggest that (a) platelet isoantibodies can be

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“…Wolf and Canale [6] detailed a fatal reaction to a red cell transfusion in a multitransfused thalassémie child with lymphocytotoxic HLA antibodies. Several recent studies have shown that the most common ly found recipient antibodies associated with nonhemo lytic febrile transfusion reactions are not directed towards granulocyte antigens but are lymphocytotoxic, directed against HLA antigens [5,8,9], Interdonor red cell incompatibility in the Kell antigen system has caused reactions of variable severity [19][20][21][22][23]. Interdonor reactions caused by RBC transfusions have been described in which the transfusion of Kell-negative red cells with Kell antibody in donor plasma at the same time as another unit of Kell-positive red cells has caused a hemolytic transfusion reaction when both units were transfused to a Kell-negative patient [19,20].…”

Section: Discussionmentioning

confidence: 99%

Platelet Transfusion Reaction Associated with Interdonor HLA Incompatibility

Eastlund¹,

McGrath²,

Burkart³

1988

Vox Sanguinis

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An HLA-compatible platelet transfusion was followed by chills, fever, and severe respiratory distress in a multitransfused patient with chronic lymphocytic leukemia. During the previous 7 days the patient had received blood products without incident, including 8 units of red blood cells (RBC), 24 units of pooled random donor platelet concentrates, and five HLA-compatible platelet pheresis products. The patient had no demonstrable RBC, HLA lymphocytotoxic, platelet or granulocyte antibodies. The platelet donor, a multiparous female, had no granulocyte or RBC antibodies but had lymphocytotoxic antibodies against HLA-A2 CREG (cross-reacting group A2, A28, A23, A24) which reacted not with lymphocytes of the patient but with lymphocytes of the donor whose RBC were transfused 24 h prior to the platelet transfusion reaction and whose HLA type is A23, A24; B44, B57. No RBC donors had HLA lymphocytotoxic, granulocyte, or platelet antibodies against the platelet donor. The patient received three subsequent platelet transfusions from the same donor after removal of the antibody-laden plasma with no adverse reaction. These data suggest an interdonor reaction caused by the presence of cells from the RBC donor received by the patient 24 h prior to the transfusion of donor lymphocytotoxic antibody to HLA-A2 CREG antigens.

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The Specificity of Leukocyte and Platelet Alloantibodies in Sera of Patients with Nonhemolytic Transfusion Reactions

Cited by 34 publications

References 15 publications

The Serology of Febrile Transfusion Reactions

The Serology of Febrile Transfusion Reactions

Detection of platelet isoantibodies by (3H)serotonin platelet release and its clinical application to the problem of platelet matching.

Platelet Transfusion Reaction Associated with Interdonor HLA Incompatibility

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