The specificity of platelet glutamate receptor supersensitivity in psychotic disorders

Berk, Michael; Plein, Helene; Belsham, Brendan

doi:10.1016/s0024-3205(00)80002-8

Cited by 55 publications

(14 citation statements)

References 19 publications

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“…The results of the present study showed that in platelets from schizophrenic patients, the activity of GPx was significantly lower than in platelets from healthy subjects (controls). This is in agreement with other studies 11,44…”

Section: Discussionsupporting

confidence: 94%

“…In the present study of oxidative stress in schizophrenic patients, blood platelets were used. Blood platelets are recognized as cellular models in neurobiological studies, because of their similarity to neurons, having the same embryological origin; platelets and neurons of the central nervous system show many similarities, including monoamine oxidase activity, serotonin reuptake, presence of neurotransmitter receptors, and exocytosis 11–14. Blood platelets are highly reactive, and within seconds of exposure to such agonists as thrombin or platelet-activating factor (PAF), they undergo activation, with a dramatic change in their morphology and biochemical events.…”

Section: Introductionmentioning

confidence: 99%

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Generation of superoxide anion radicals and platelet glutathione peroxidase activity in patients with schizophrenia

Dietrich‐Muszalska¹,

Kwiatkowska²

2014

NDT

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Blood platelets are considered to be a peripheral marker in schizophrenia and other psychiatric disorders. Oxidative stress in schizophrenia may be responsible for changes in platelet metabolism and function; therefore, the aim of this study was to examine and compare the generation of superoxide anions and activity of an antioxidant enzyme (glutathione peroxidase [GPx]) in blood platelets in patients with schizophrenia and healthy subjects. The level of superoxide anions generated in platelets after thrombin and platelet-activating factor stimulation and activity of GPx in patients with schizophrenia and healthy volunteers was estimated. The results obtained from the study indicate that the generation of superoxide anions in platelets as a response of platelets in patients with schizophrenia to such activating factors as thrombin or platelet-activating factor is higher than in the response of platelets of healthy subjects. In platelets from schizophrenic patients, suppressed GPx activity of about 67% was observed.

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Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Generation of superoxide anion radicals and platelet glutathione peroxidase activity in patients with schizophrenia

Dietrich‐Muszalska¹,

Kwiatkowska²

2014

NDT

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“…Platelet-dense granules also contain and release glutamate, which is an important neurotransmitter (12–15). A major class of glutamate receptors includes the ionotropic glutamate receptors ( N -methyl-D-aspartate [NMDA], kainate, and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid [AMPA] receptors [AMPARs]).…”

mentioning

confidence: 99%

Glutamate mediates platelet activation through the AMPA receptor

Morrell

Sun²,

Ikeda

et al. 2008

The Journal of Experimental Medicine

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Glutamate is an excitatory neurotransmitter that binds to the kainate receptor, the N-methyl-D-aspartate (NMDA) receptor, and the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor (AMPAR). Each receptor was first characterized and cloned in the central nervous system (CNS). Glutamate is also present in the periphery, and glutamate receptors have been identified in nonneuronal tissues, including bone, heart, kidney, pancreas, and platelets. Platelets play a central role in normal thrombosis and hemostasis, as well as contributing greatly to diseases such as stroke and myocardial infarction. Despite the presence of glutamate in platelet granules, the role of glutamate during hemostasis is unknown. We now show that activated platelets release glutamate, that platelets express AMPAR subunits, and that glutamate increases agonist-induced platelet activation. Furthermore, we demonstrate that glutamate binding to the AMPAR increases intracellular sodium concentration and depolarizes platelets, which are important steps in platelet activation. In contrast, platelets treated with the AMPAR antagonist CNQX or platelets derived from GluR1 knockout mice are resistant to AMPA effects. Importantly, mice lacking GluR1 have a prolonged time to thrombosis in vivo. Our data identify glutamate as a regulator of platelet activation, and suggest that the AMPA receptor is a novel antithrombotic target

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“…However, the question remained as to whether this response was specific to schizophrenia, or whether it would also be found in other psychotic conditions. In another study by the same group, patients with schizophrenia, psychotic depression, mania with psychotic features and control subjects were compared, and the same methodology used on isolated platelets (56). It showed that in both schizophrenia and psychotic depression there was an increase in the intracellular calcium response to glutamate stimulation but that there were no alterations in this marker in patients with mania compared with control subjects.…”

Section: Glutamatementioning

confidence: 99%

The platelet window: examining receptor regulated second messenger processes in psychosis and depression

Berk

Malhi

2003

Acta Neuropsychiatr.

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Peripheral markers of psychiatric illness provide a potentially important window into the pathophysiology of a number of psychiatric illnesses. Direct access to pathophysiological processes is fraught with difficulty. However, receptor-regulated second messenger-mediated calcium shifts are an accessible and practical method by which to examine changes in a clinical population. This is possible because platelets and neurons share some physiological features. The platelet intracellular calcium response to receptor stimulation has previously been used as a peripheral marker of psychiatric illness across a range of neurotransmitters, including serotonin, dopamine and glutamate. This review considers the specificity and selectivity of this response and its use in psychotic and mood disorders.

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The specificity of platelet glutamate receptor supersensitivity in psychotic disorders

Cited by 55 publications

References 19 publications

Generation of superoxide anion radicals and platelet glutathione peroxidase activity in patients with schizophrenia

Generation of superoxide anion radicals and platelet glutathione peroxidase activity in patients with schizophrenia

Glutamate mediates platelet activation through the AMPA receptor

The platelet window: examining receptor regulated second messenger processes in psychosis and depression

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