The Spectral Dependence for UVA-Induced Cumulative Damage in Human Skin

Lavker, Robert M.; Kaidbey, Kays H.

doi:10.1111/1523-1747.ep12285613

Cited by 112 publications

(96 citation statements)

References 28 publications

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“…10 Cumulative UVA induces thickening of the viable epidermis and deposition of lysozyme in elastic fibers. 17 Our results demonstrate possible consequences of these previous histologic findings by showing a significant decrease of skin laxity and elasticity on window-exposed skin, as well as a decrease in skin color heterogeneity. Chromophores may be less visible due to increased epidermal thickness.…”

Section: Discussionsupporting

confidence: 74%

“…9 Various studies are available that describe the ability of UVA to cause changes in cells in culture and in vivo. 10,11,17 Human studies have demonstrated that even relatively low doses of UVA given repetitively can induce changes associated with photoaging, including decreased elastic tissue content and stratum corneum thickening. 10,11 These findings have also been replicated in whole animal studies, with hairless mice subjected to repeated UVA exposure developing wrinkles and other signs of photodamage, together with histologic changes in dermal tissues and increased levels of matrix metalloproteinase-1.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of cumulative exposure to UVA through study of asymmetric facial skin damage

Mac-Mary

Sainthillier²,

Jeudy³

et al. 2010

CIA

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Background: Published studies assessing whether asymmetrical facial ultraviolet light exposure leads to underlying differences in skin physiology and morphology report only clinical observations. The aim of this study was to assess the visual impact on the skin of repeated ultraviolet-A (UVA) exposure through a window. Methods: Eight women and two men presenting with asymmetrical signs of photoaging due to overexposure of one side of their face to the sun through a window over a long period of time were enrolled in the study. Split-face biometrologic assessments were performed (clinical scoring, hydration with Corneometer ® , mechanical properties with Cutometer ® , transepidermal water loss with AquaFlux ® , skin relief with fringe projection, photography, stripping, and then lipid peroxidation analysis). Results: Significant differences were observed in clinical scores for wrinkles, skin roughness assessed by fringe projection on the cheek, and skin heterogeneity assessed with spectrocolorimetry on the cheekbone. Other differences were observed for skin hydration, as well as skin laxity, which tended towards significance. Discussion: This study suggests the potential benefit of daily UVA protection during nondeliberate exposure indoors as well as outside.

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Section: Discussionsupporting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Assessment of cumulative exposure to UVA through study of asymmetric facial skin damage

Mac-Mary

Sainthillier²,

Jeudy³

et al. 2010

CIA

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“…1 Chronic UV sun exposure leads to clinical changes in the skin such as laxity/tone, roughness, dryness, sallowness/yellowing, pigmentation, telangiectasia, and wrinkles. 2 Reactive oxygen species such as free radicals unquestionably produce oxidative damage in skin. Ultraviolet light contributes directly to photodamage, not only by generating reactive oxygen species but also by depressing antioxidant levels.…”

mentioning

confidence: 99%

Use of Topical Ascorbic Acid and Its Effects on Photodamaged Skin Topography

Traikovich

1999

Arch Otolaryngol Head Neck Surg

142

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Objective: To determine the efficacy of topical ascorbic acid application in treating mild to moderate photodamage of facial skin using an objective, computerassisted image analysis of skin surface topography and subjective clinical, photographic, and patient selfappraisal questionnaires.Design: A 3-month, randomized, double-blind, vehiclecontrolled study.Setting: Facial plastic surgery private practice.Patients: Nineteen evaluable volunteer sample patients aged between 36 and 72 years with Fitzpatrick skin types I, II, and III who were in good physical and mental health with mild to moderately photodamaged facial skin were considered for analysis.Intervention: Coded, unmarked medications were randomly assigned to the left and right sides of each subject's face, one containing the active agent, topical ascorbic acid (Cellex-C high-potency serum; Cellex-C International, Toronto, Ontario), the other, the vehicle serum (Cellex-C International). Three drops (0.5 mL) of each formulation were applied daily to the randomly assigned hemifaces over the 3-month study period. Treatment assignments were not disclosed to subjects, clinicians, or personnel involved in analyzing skin replicas. Main Outcome Measures:Specific clinical parameters were evaluated and graded on a 0-to 9-point scale (0, none; 1-3, mild; 4-6, moderate; and 7-9, severe). Reference photographs were used to standardize grading criteria. Overall investigator scores were compared with baseline and graded as excellent (much improved), good (improved), fair (slightly improved), no change, or worse. Patient self-appraisal questionnaires rated the degree of improvement (much improved, improved, slightly improved, no change, or worse) and reported adverse effects (burning, stinging, redness, peeling, dryness, discoloration, itching, and rash). Standard photographs were taken at baseline, including anteroposterior and left and right oblique views to facilitate subsequent clinical evaluations, and at the end of therapy for comparison. Optical profilometry analysis was performed on the skin surface replicas of the lateral canthal (crow's feet) region, comparing baseline to end-of-study specimens. Using this computer-based system, the resulting image was digitally analyzed, and numeric values were assigned to reflect surface features. The parameters obtained included R z , R a , and shadows. These values provided objective data that document pretreatment and posttreatment texture changes proportional to the degree of wrinkling, roughness, and other surface irregularities.Results: Optical profilometry image analysis demonstrated a statistically significant 73.7% improvement in the R a and shadows north-south facial axis values with active treatment greater than vehicle control, as well as a trend for improvement in the R z north-south facial axis parameter, showing a 68.4% greater improvement of active treatment vs vehicle control. Clinical assessment demonstrated significant improvement with active treatment greater than control for fine wrinkling, tactile roughnes...

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“…When intracellular ROS increases, through various intracellular signal transmission processes, it hinders collagen synthesis and promotes MMP expression which is an enzyme to decompose collagen to accelerate causing wrinkles and skin aging (Lavker and Kaidbey 1997). Also oxidative stress is deeply related to not only skin aging but also inflammation reaction so that it has an influence on controlling activity of various kinds of cells.…”

Section: Antioxidation Effects Of β-Eudesmolmentioning

confidence: 99%

Anti-inflammatory and ECM gene expression modulations of β-eudesmol via NF-κB signaling pathway in normal human dermal fibroblasts

Kim¹

2018

biomed dermatol

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Background: β-eudesmol is a kind of aromatic compound belonging to sesquiterpenoid which exists within not only the bark of magnolia but also Nardostachys jatamansi, Atractylodes lancea, Pterocarpus santalinus, Ginkgo bilobal, Cryptomeria japonica, etc., and there has been progress in medical and pharmaceutic researches on antitumor, anticancer, and anti-inflammatory effects; nervous system stabilization; and vasodilator effects, etc., but not in researches on skin cares and cosmetics at all. Therefore, this study pretreated β-eudesmol with human dermal fibroblasts (HDFs) and then gave oxidative stresses with H 2 O 2 to examine antioxidation, anti-inflammatory, and cell preservation effects. Through this process, it proves the possibility of β-eudesmol as cosmetic materials. Methods: This study verified the effectiveness of β-eudesmol through cell viability analysis, reactive oxygen estimation, associated β-galactosidase assay, nuclear factor-kappa B (NF-κB) luciferase assay, and quantitative real-time polymerase chain reaction (qRT-PCR). Results: The cell viability which decreased due to H 2 O 2 increased as per dose-dependent manners of β-eudesmol. Also, at the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity assay, intracellular reactive oxygen species (ROS) quantitative analysis and glutathione (GSH) estimation, the relative levels which were changed by H 2 O 2 treatment, showed attenuated or protective transition forms, depending on the concentration of β-eudesmol. Additionally, reduced superoxide dismutase 1 (SOD1) and catalase (CAT) gene expression by H 2 O 2 were increased by β-eudesmol. As the result of the promoter activity analysis of NF-κB which has a key role in inflammation and skin aging, NF-κB activity decreases as β-eudesmol concentration increases, and also this study proves that gene expression of interleukin 1 beta (IL-1β) which is a downstream gene of NF-κB related to inflammatory response decreases as well as tumor necrosis factor-alpha (TNF-α) gene expression depending on the concentration of β-eudesmol. Conclusions: Through these results, this study suggests there are anti-inflammatory effects by shutting out the NF-κB pathway. Following the results of the extracellular matrix (ECM) regulating gene expression analysis, this study proves that oxidative stress-induced increased MMP1 levels were decreased depending on the concentration of β-eudesmol and verifies that it hinders the collapse of collagen through inhibition of transcriptional activity of NF-κB. From the result of β-eudesmol regulating tissue inhibitors of metalloproteinase (TIMP)-1 gene expression which hinders matrix metalloproteinase (MMP), activation and alteration of gene expression of collagen type I alpha 1 (COL1A1) underpins the above consequences. Through this research, it is considered that β-eudesmol as one of natural cosmetic materials with such effects as antioxidation, anti-inflammation, and cell preservation is worthy of notice.

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The Spectral Dependence for UVA-Induced Cumulative Damage in Human Skin

Cited by 112 publications

References 28 publications

Assessment of cumulative exposure to UVA through study of asymmetric facial skin damage

Assessment of cumulative exposure to UVA through study of asymmetric facial skin damage

Use of Topical Ascorbic Acid and Its Effects on Photodamaged Skin Topography

Anti-inflammatory and ECM gene expression modulations of β-eudesmol via NF-κB signaling pathway in normal human dermal fibroblasts

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