The spectrum between antiphospholipid syndrome and systemic lupus erythematosus

Agmon‐Levin, Nancy; Shoenfeld, Yehuda

doi:10.1007/s10067-014-2486-5

Cited by 13 publications

(13 citation statements)

References 34 publications

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“…The interplay between SLE and APS has been analyzed over the years, since APS was initially not considered to be a systemic AD and was thought to occur only in patients with SLE [27] – [29] . Furthermore, APS has been found to be associated with systemic manifestations (e.g., non-thrombotic renal disease, migraine, livedo reticularis, pulmonary hypertension, MI) and laboratory features (e.g., positive ANAs, hypocomplementemia) also present in patients with SLE, complicating the clear differentiation between these entities [27] – [29] . However, rather than being the spectrum of the same disease, the coexistence of APS and SLE is a reflection of complex disease traits and highlights the common mechanisms shared by ADs [1] , [4] .…”

Section: Discussionmentioning

confidence: 99%

The Coexistence of Antiphospholipid Syndrome and Systemic Lupus Erythematosus in Colombians

et al. 2014

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ObjectivesTo examine the prevalence and associated factors related to the coexistence of antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) in a cohort of Colombian patients with SLE, and to discuss the coexistence of APS with other autoimmune diseases (ADs).MethodA total of 376 patients with SLE were assessed for the presence of the following: 1) confirmed APS; 2) positivity for antiphospholipid (aPL) antibodies without a prior thromboembolic nor obstetric event; and 3) SLE patients without APS nor positivity for aPL antibodies. Comparisons between groups 1 and 3 were evaluated by bivariate and multivariate analysis.ResultsAlthough the prevalence of aPL antibodies was 54%, APS was present in just 9.3% of SLE patients. In our series, besides cardiovascular disease (AOR 3.38, 95% CI 1.11–10.96, p = 0.035), pulmonary involvement (AOR 5.06, 95% CI 1.56–16.74, p = 0.007) and positivity for rheumatoid factor (AOR 4.68, 95%IC 1.63–14.98, p = 0.006) were factors significantly associated with APS-SLE. APS also may coexist with rheumatoid arthritis, Sjögren's syndrome, autoimmune thyroid diseases, systemic sclerosis, systemic vasculitis, dermatopolymyositis, primary biliary cirrhosis and autoimmune hepatitis.ConclusionsAPS is a systemic AD that may coexist with other ADs, the most common being SLE. Awareness of this polyautoimmunity should be addressed promptly to establish strategies for controlling modifiable risk factors in those patients.

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Section: Discussionmentioning

confidence: 99%

The Coexistence of Antiphospholipid Syndrome and Systemic Lupus Erythematosus in Colombians

et al. 2014

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“…Environmental factors seem to contribute to induction of such an autoantibody. Additional factors, such as infections, hormones, vitamins and sun exposure, are important in the production of APS and SLE ( 11 ). Antiphospholipid antibodies are a heterogeneous group of antibodies, in which a majority react with proteins bound to phospholipids ( 4 , 7 ) and their presence can be determined by assessing the anticardiolipin antibodies (ACLA), lupus anticoagulant (LA), and beta2-glycoprotein I antibody in the patient’s serum ( 5 , 7 ).…”

Section: Discussionmentioning

confidence: 99%

Pulmonary embolism in an adolescent girl with negative ACLA systemic lupus erythematosus (SLE): a case report

et al. 2016

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Pulmonary involvement is a common manifestation in systemic lupus erythematosus (SLE), whereas pulmonary thromboembolism (PTE) is rarely seen in SLE. PTE related to anti-phospholipid antibody syndrome (APS) is also a rare disease. We have reported a 13-year-old female diagnosed with SLE Two years ago, who is being treated with hydroxychloroquine and prednisolone. She presented with shortness of breath, dry cough, and fever about two weeks prior to admission. She was initially admitted with the diagnosis of pneumonia, but no clinical improvement was seen she was given antibiotics. Hemoptysis was added to her symptoms, so spiral high resolution computed tomography (HRCT) of the lungs was requested, and it indicated patchy consolidations bilaterally. With suspicion of pulmonary thromboembolism (PTE), spiral computed tomography angiography of pulmonary vessels was done, revealing PTE. After initiation of anti-coagulants, her clinical condition and respiratory status improved significantly. We present a rare case of SLE where only lupus anti-coagulant test was abnormal while other tests, such as anti-cardiolipin antibody and anti-phospholipid antibody were normal. Therefore, we can conclude that clinical suspicion had the main role in diagnosis in our case, as it has in medicine.

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“…Based on many similarities with SLE, some authors indicate possible systemic character of APS and raise an intriguing question: are http://www.mjms.mk/ http://www.id-press.eu/mjms/ APS and SLE two separate autoimmune disorders or represent one same autoimmune phenomenon? [53,54].…”

Section: Is Antiphospholipid Syndrome a Systemic Autoimmune Disorder?mentioning

confidence: 99%

Systemic Lupus Erythematosus and Antiphospholipid Syndrome

Plavšić¹,

Mišković²,

Rašković

et al. 2014

Open Access Maced J Med Sci

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Antiphospholipid syndrome is an autoimmune disorder defined as association of vascular thrombosis and/or pregnancy complications with presence of antiphospholipid antibodies (lupus anticoagulant, anticardiolipin and anti-β2 glycoprotein I). It is the most common cause of acquired thrombophilia, and can occur as an independent entity or in relation with other diseases, especially systemic lupus erythematosus. Presence of antiphospholipid syndrome in systemic lupus erythematosus is additional vaso occlusive factor in already present inflammation, bringing further risk for thrombotic events. Clinical and serological manifestations of antiphospholipid syndrome and systemic lupus erythematosus are very similar, so possible connection for these two autoimmune disorders is assumed.

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The spectrum between antiphospholipid syndrome and systemic lupus erythematosus

Cited by 13 publications

References 34 publications

The Coexistence of Antiphospholipid Syndrome and Systemic Lupus Erythematosus in Colombians

The Coexistence of Antiphospholipid Syndrome and Systemic Lupus Erythematosus in Colombians

Pulmonary embolism in an adolescent girl with negative ACLA systemic lupus erythematosus (SLE): a case report

Systemic Lupus Erythematosus and Antiphospholipid Syndrome

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