The Spectrum of Glomerular Diseases on Renal Biopsy: Data From A Single Tertiary Center In Oman

Riyami, Dawood Al; Shaaili, K. Al; Bulushi, Y. Al; Dhahli, A. Al; Date, Anand

doi:10.5001/omj.2013.58

Cited by 15 publications

(19 citation statements)

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“…13,14,20 Among primary glomerular diseases, FSGS was the most frequent pathological lesion (27.44%) encountered in our study which is similar to data from regional Asian studies. [13][14][15] However, these results depart from those reported in other published papers which show a relatively low incidence of FSGS. 18,21 MCD was found to be more common in the younger age group (18.61±13.47 years) and it was the second most frequent pathology encountered in our study (16.01%) which is identical to other studies from India, Korea, and Japan.…”

Section: Discussioncontrasting

confidence: 98%

“…13,20 In Oman, MCD was not detected among the diagnosed renal and glomerular pathologies which can be due to the higher age group of participants (patient) involved in that study. 15 MGN was more common in the older age group of our patients (38.94±13.69 years), and it represents the third most frequent diagnosis among patients with primary glomerular diseases which is identical data to other studies. 14,16,19 In Iran, MGN was the most frequent renal pathology encountered among patients with primary glomerular diseases.…”

Section: Discussionsupporting

confidence: 91%

“…[13][14][15] There was a slight male predominance in our study which is comparable to the other studies in contrast to the published work of Dawood and coworkers (Oman) and Sugiyama and colleagues (Japan) where the male-tofemale ratio was different. 15,16 There are large differences in reporting the underlying causes of nephrotic syndrome in different regions of the world and among different ethnicities, for instance in the United States, where FSGS is the commonest underlying pathology with an increasing incidence among all ethnic groups. 17 IgA nephropathy was more frequent in European patients while FSGS is infrequent with no increment in the incidence.…”

Section: Discussionsupporting

confidence: 82%

“…17,22 IgAN is the most frequent glomerular disease in Japan and Korea and it was less encountered in our study which is compatible with data from other regional Asian studies. 14,15,16,19,23 Secondary glomerular disease ranked 2 nd following the most common primary glomerular disease. In our patients, Lupus nephritis was the most common secondary glomerular disease followed by amyloidosis and diabetic nephropathy which was identical to all other studies.…”

Section: Discussionmentioning

confidence: 99%

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The Spectrum of Biopsy-Proved Kidney Disease: A Retrospective Single Center Study in Erbil-Iraq

Al-Imam

Ali²,

Al-Mukhtar³

2019

Asian J Med Sci

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BACKGROUND Renal biopsy is crucial to determine the pattern of the different types of renal diseases. It represents the gold standard of diagnostics for renal pathologies, including glomerular diseases, and it has an important value for the prognosis, monitoring disease progression, and planning the management protocol. AIMS AND OBJECTIVE To report the frequency of different pathological lesions affecting the kidney in patients who were admitted to our medical centre. MATERIALS AND METHODS This is a retrospective study of all patients with renal diseases who underwent percutaneous renal biopsy at the Erbil Kidney Centre for eight years (1st of January 2010 to 31st of December 2017). A total of 893 cases were biopsied and subsequently studied via histopathological examination and immunofluorescence microscopy. The study is ethically permitted by the Kurdistan Board for Medical Specialization. RESULTS The average age of the patients was 30.9 years. The most common clinical indication for biopsy included nephrotic syndrome (46.47%), acute renal failure (19.04%), chronic renal failure (15.34%), nephritic syndrome (7.39%), proteinuria alone (7.28%), and hematuria alone (4.48%). In patients with a primary glomerular disease, focal segmental glomerulosclerosis and minimal change disease were the most frequent (27.44% and 16.01%) in the younger patients (18.61±13.47 years), while membranous glomerulonephritis was more common in older patients (38.94±13.69 years). Patients with a secondary glomerular disease were mainly diagnosed with lupus nephritis, amyloidosis, and diabetic nephropathy. CONCLUSION The epitome of our study signifies that the spectrum of glomerular diseases varies based on age, sex, ethnicity, and geographical distribution. The implementation of renal biopsy proved to be a cornerstone in reaching the correct diagnosis. Future studies should implement the use of electron microscopy in conjunction with classical techniques of histopathology and immunofluorescence microscopy to diagnose equivocal cases of interest.

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Section: Discussioncontrasting

confidence: 98%

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

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The Spectrum of Biopsy-Proved Kidney Disease: A Retrospective Single Center Study in Erbil-Iraq

Al-Imam

Ali²,

Al-Mukhtar³

2019

Asian J Med Sci

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“…11 The study groups defined in these comprised of a higher proportion of children and young adults(<18yrs) ,around 31.15% of total subjects.The younger group(<18yrs) included in our study was only 6.87% of the total subjects.This could have accounted for the lower incidence of MCD reported. DN was the most common SGD in this study, on contrary to other studies where LN was reported as the most prevalent SGD 3,11,20,21 . DN was seen in 14.90% of total subjects (35.03% of all SGDs),with mean age of 50.48yrs, and mean creatinine of 5.69mg/dl.…”

Section: Discussioncontrasting

confidence: 52%