The Spinal Cord and Peripheral Nervous System

Bradley, Alys; Roulois, Aude; McKay, Jenny; Parry, N.; Boorman, Gary A.

doi:10.1016/b978-0-12-391448-4.00014-9

Cited by 2 publications

(3 citation statements)

References 89 publications

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“…As noted by audience participants, this may be seen in the spinal cord and spinal nerve roots at all levels in aged rats of various strains, although exact incidence rates are not always reported. [39][40][41] Degeneration in the spinal cord occurs in aging mice as well, though at a lower frequency than in rats, 36 as seen in this data cohort (Table 3). In mice, degeneration was most frequently recorded in the thoracic spinal cord during the queried period.…”

Section: Nervous System Findings In Ntp Control Mice and Ratssupporting

confidence: 63%

Proceedings of the 2021 National Toxicology Program Satellite Symposium

et al. 2021

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The 2021 annual National Toxicology Program (NTP) Satellite Symposium, entitled “Pathology Potpourri,” was the 20th anniversary of the symposia and held virtually on June 25th, in advance of the Society of Toxicologic Pathology’s 40th annual meeting. The goal of this symposium was to present and discuss challenging diagnostic pathology and/or nomenclature issues. This article presents summaries of the speakers’ talks along with select images that were presented to the audience for voting and discussion. Various lesions and topics covered during the symposium included differentiation of canine oligodendroglioma, astrocytoma, and undefined glioma with presentation of the National Cancer Institute’s updated diagnostic terminology for canine glioma; differentiation of polycystic kidney, dilated tubules and cystic tubules with a discussion of human polycystic kidney disease; a review of various rodent nervous system background lesions in control animals from NTP studies with a focus on incidence rates and potential rat strain differences; vehicle/excipient-related renal lesions in cynomolgus monkeys with a discussion on the various cyclodextrins and their bioavailability, toxicity, and tumorigenicity; examples of rodent endometrial tumors including intestinal differentiation in an endometrial adenocarcinoma that has not previously been reported in rats; a review of various rodent adrenal cortex lesions including those that represented diagnostic challenges with multiple processes such as vacuolation, degeneration, necrosis, hyperplasia, and hypertrophy; and finally, a discussion of diagnostic criteria for uterine adenomyosis, atypical hyperplasia, and adenocarcinoma in the rat.

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Section: Nervous System Findings In Ntp Control Mice and Ratssupporting

confidence: 63%

Proceedings of the 2021 National Toxicology Program Satellite Symposium

et al. 2021

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“…16 Reticulin special stain and/or electron microscopy can be used to highlight the continuous basal lamina, a feature of schwannoma cells. 19,20 Histologic variants of schwannoma include cellular (primarily Antoni A configuration but lacking Verocay bodies), granular (appears similar to granular cell tumor), melanotic (has pigmented melanosomes), and plexiform (multinodular pattern in various nerve branches). 19…”

Section: Metastatic Periocular Schwannoma In a Ratmentioning

confidence: 99%

“…The head and neck are also commonly reported sites for schwannomas in the rodent, with reports in the literature representing the brain (meninges and pituitary gland), 32 trigeminal nerve and ganglion, 32 eye (including retrobulbar region), mandibular salivary gland, skin/subcutis, and more. 20 In the presentation, Dr Krane reinforced the importance of carefully examining all regions of the head and neck if schwannoma was a concern in the study, as these tumors can extend through a variety of locations in the head and neck region. One audience member mentioned that many of these structures of the head and neck are supplied by branches of the trigeminal nerve and indicated a hypothesis that there may be a population of pluripotent stem cells at the trigeminal nerve susceptible for schwannoma induction.…”

Section: Metastatic Periocular Schwannoma In a Ratmentioning

confidence: 99%

Proceedings of the 2019 National Toxicology Program Satellite Symposium

et al. 2019

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The 2019 annual National Toxicology Program Satellite Symposium, entitled “Pathology Potpourri,” was held in Raleigh, North Carolina, at the Society of Toxicologic Pathology’s 38th annual meeting. The goal of this symposium was to present and discuss challenging diagnostic pathology and/or nomenclature issues. This article presents summaries of the speakers’ talks along with select images that were used by the audience for voting and discussion. Various lesions and topics covered during the symposium included aging mouse lesions from various strains, as well as the following lesions from various rat strains: rete testis sperm granuloma/fibrosis, ovarian cystadenocarcinoma, retro-orbital schwannoma, periductal cholangiofibrosis of the liver and pancreas, pars distalis hypertrophy, chronic progressive nephropathy, and renal tubule regeneration. Other cases included polyovular follicles in young beagle dogs and a fungal blood smear contaminant. One series of cases challenged the audience to consider how immunohistochemistry may improve the diagnosis of some tumors. Interesting retinal lesions from a rhesus macaque emphasized the difficulty in determining the etiology of any particular retinal lesion due to the retina’s similar response to vascular injury. Finally, a series of lesions from the International Harmonization of Nomenclature and Diagnostic Criteria Non-Rodent Fish Working Group were presented.

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The Spinal Cord and Peripheral Nervous System

Cited by 2 publications

References 89 publications

Proceedings of the 2021 National Toxicology Program Satellite Symposium

Proceedings of the 2021 National Toxicology Program Satellite Symposium

Proceedings of the 2019 National Toxicology Program Satellite Symposium

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